5,7,8-三氯-6-甲氧基-喹啉 | 5423-58-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 5,7,8-三氯-6-甲氧基-喹啉
• 英文名称: 5,7,8-trichloro-6-methoxy-quinoline
• 英文别名: 5,7,8-Trichlor-6-methoxy-chinolin；5,7,8-Trichloro-6-methoxyquinoline
• CAS: 5423-58-5
• 化学式: C₁₀H₆Cl₃NO
• 分子量: 262.523
• InChiKey: OWRQGDLYWWGEIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2933499090

反应信息

• 作为产物：
  描述：

  6-甲氧基-8-硝基喹啉 在 磺酰氯 作用下， 生成 5,7,8-三氯-6-甲氧基-喹啉
  参考文献：
  名称：

  6-甲氧基-8-硝基喹啉的衍生物；用硫酰氯氯化。

  摘要：

  DOI：

  10.1021/jo01172a008

文献信息

• IDENTIFICATION AND USE OF COMPOUNDS THAT AFFECT THE FIDELITY OF EUKARYOTIC TRANSLATION INITIATION CODON SELECTION
  申请人：Lorsch Jon R.

  公开号：US20110230451A1

  公开（公告）日：2011-09-22

  A screening method for identifying compounds that alter the fidelity with which the initiation codon in mRNAs is recognized by the translational apparatus in eukaryotes is disclosed. This screening method was used to identify compounds having such activity. Methods of altering the fidelity of initiation codon selection are also disclosed. Methods of treating disorders characterized by single nucleotide mutations in initiation codons using compounds identified by the screening method, as well as methods of treating fungal and parasitic infections and hyperproliferative disorders using compounds identified by the screening method are also disclosed.
• US8828976B2
  申请人：——

  公开号：US8828976B2

  公开（公告）日：2014-09-09
• DERIVATIVES OF 6-METHOXY-8-NITROQUINOLINE. CHLORINATION WITH SULFURYL CHLORIDE
  作者：J. SCHULTZ、M. A. GOLDBERG、G. CARSCH、E. P. ORDAS

  DOI：10.1021/jo01172a008

  日期：1946.3