3-(8-Chloroquinolin-4-yl)phenol | 1207842-25-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-(8-Chloroquinolin-4-yl)phenol
• CAS: 1207842-25-8
• 化学式: C₁₅H₁₀ClNO
• 分子量: 255.703
• InChiKey: MXQSKQDOVKJPOT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4,8-二氯喹啉 、 3-羟基苯硼酸 在 potassium phosphate 作用下， 以 1,4-二氧六环 为溶剂， 反应 16.0h， 生成 3-(8-Chloroquinolin-4-yl)phenol
  参考文献：
  名称：

  4-(3-Aryloxyaryl)quinoline sulfones are potent liver X receptor agonists

  摘要：

  A series of 4-(3-aryloxyaryl)quinolines with sulfone substituents on the terminal aryl ring (7) was prepared as LXR agonists. High affinity LXR ligands with excellent agonist potency and efficacy in functional assays of LXR activity were identified. In general, these sulfone agonists were equal to or superior to previously described alcohol and amide analogs in terms of affinity, functional potency, and microsomal stability. Many of the sulfones had LXR beta binding IC(50) values <10 nM while the most potent compounds in an ABCA1 mRNA induction assay in J774 mouse cells had EC(50) values <10 nM and were as efficacious as T0901317. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.10.132

文献信息

• QUINOLINE COMPOUNDS
  申请人：Wyeth

  公开号：EP2074098A2

  公开（公告）日：2009-07-01
• [EN] QUINOLINE COMPOUNDS<br/>[FR] COMPOSÉS DE QUINOLÉINE
  申请人：WYETH CORP

  公开号：WO2008049047A2

  公开（公告）日：2008-04-24

  [EN] This invention relates generally to quinoline-based modulators of Liver X receptors (LXRs) and related methods.
  [FR] La présente invention concerne de manière générale des modulateurs à base de quinoléine des récepteurs X du foie (LXR) et des procédés associés.