2-nitrophenyl pyridin-3-yl ketone | 3882-45-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-nitrophenyl pyridin-3-yl ketone
• 英文别名: 3-(2-Nitro-benzoyl)-pyridin；(2-nitro-phenyl)-pyridin-3-yl-methanone；3-(2-Nitrobenzoyl)pyridine；(2-Nitrophenyl)-pyridin-3-ylmethanone
• CAS: 3882-45-9
• 化学式: C₁₂H₈N₂O₃
• 分子量: 228.207
• InChiKey: MFPIKHKCGRKOLN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  75.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-nitrophenyl pyridin-3-yl ketone 在 硫酸 、 5%-palladium/activated carbon 、 氢气 、 sodium nitrite 作用下， 以 乙醇 、 水 为溶剂， 反应 1.25h， 生成 4-氮杂-9-芴酮
  参考文献：
  名称：

  An investigation on the second-order NLO properties of novel cationic cyclometallated Ir(III) complexes of the type [Ir(2-phenylpyridine)2(9-R-4,5-diazafluorene)]+ (R=H, fulleridene) and the related neutral complex with the new 9-fulleriden-4-monoazafluorene ligand

  摘要：

  Novel cationic cyclometallated Ir(III) complexes bearing diaza-or monoazafluorene substituted or not with a C60-fullerene moiety have been synthesized together with a novel interesting ligand 9-fulleriden-4-monoazafluorene and the related Ir(III) neutral complex [Ir(ppy)(2)(9-fulleriden-4-monoazafluorene)]. All complexes show a negative large value of mu beta(1.907) (600 to 2190 x 10(-48) esu), as determined by the Electric Field Induced Second Harmonic generation (EFISH) technique working at 1.907 mu m in 10(-3)M CH2Cl2 solution. The NLO response increases upon introduction of the fullerene moiety, due to a decrease of the interaction forces between the anion and cation within the ion pair which leads to an increase of the percentage of free ions, as evidenced by diffusion NMR experiments. Besides, it appeared that for the neutral complex [Ir(ppy)(2)(9-fulleriden-4-monoazafluorene)] the EFISH mu beta(1.907) value is lower than that of cationic Ir(III) complexes, but comparable or slightly lower to the values of other neutral Ir(III) complexes such as [Ir(ppy)(2)(RCOCR'COR)] (ppy = cyclometallated 2-phenylpyridine; R = Me, Ph; R' = H, 2,4-dinitrophenyl), confirming that the second-order NLO response of these neutral chromophores is dominated by ILCT processes concerning cyclometallated 2-phenylpyridines. (C) 2011 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2011.10.018
• 作为产物：
  描述：

  (2-nitrophenyl)(pyridin-3-yl)methanol 在 manganese(IV) oxide 作用下， 以 二氯甲烷 为溶剂， 反应 144.0h， 以80%的产率得到2-nitrophenyl pyridin-3-yl ketone
  参考文献：
  名称：

  An investigation on the second-order NLO properties of novel cationic cyclometallated Ir(III) complexes of the type [Ir(2-phenylpyridine)2(9-R-4,5-diazafluorene)]+ (R=H, fulleridene) and the related neutral complex with the new 9-fulleriden-4-monoazafluorene ligand

  摘要：

  Novel cationic cyclometallated Ir(III) complexes bearing diaza-or monoazafluorene substituted or not with a C60-fullerene moiety have been synthesized together with a novel interesting ligand 9-fulleriden-4-monoazafluorene and the related Ir(III) neutral complex [Ir(ppy)(2)(9-fulleriden-4-monoazafluorene)]. All complexes show a negative large value of mu beta(1.907) (600 to 2190 x 10(-48) esu), as determined by the Electric Field Induced Second Harmonic generation (EFISH) technique working at 1.907 mu m in 10(-3)M CH2Cl2 solution. The NLO response increases upon introduction of the fullerene moiety, due to a decrease of the interaction forces between the anion and cation within the ion pair which leads to an increase of the percentage of free ions, as evidenced by diffusion NMR experiments. Besides, it appeared that for the neutral complex [Ir(ppy)(2)(9-fulleriden-4-monoazafluorene)] the EFISH mu beta(1.907) value is lower than that of cationic Ir(III) complexes, but comparable or slightly lower to the values of other neutral Ir(III) complexes such as [Ir(ppy)(2)(RCOCR'COR)] (ppy = cyclometallated 2-phenylpyridine; R = Me, Ph; R' = H, 2,4-dinitrophenyl), confirming that the second-order NLO response of these neutral chromophores is dominated by ILCT processes concerning cyclometallated 2-phenylpyridines. (C) 2011 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2011.10.018

文献信息

• Benzodiazepine derivatives useful as CCK-Receptor Antagonists
  申请人：YAMANOUCHI PHARMACEUTICAL CO., LTD.

  公开号：EP1342719A1

  公开（公告）日：2003-09-10

  A benzodiazepine derivative of formula I, or a pharmaceutically acceptable salt thereof: wherein (a) R1 is -CH2CHOH(CH2)aR4 or a ketone group -CH2CO(CH2)aR5 in which a is 0 or 1 and R4 and R5 are selected from alkyl groups of up to 8 carbon atoms; (b) R2 and R3 are independently selected from optionally substituted monocyclic aromatic carbocylic and heterocyclic residues of 5 or 6 ring atoms of which one, two or three may be heteroatoms, the optional substituents being selected from halogen atoms and hydroxy, amino, nitro, carboxylic acid, carboxamido and cyano groups and alkyl, alkoxy, alkylamino and dialkylamino groups in which the or each alkyl group is of up to 8 carbon atoms; and (c) W and X are selected independently from halogen and hydrogen atoms and C1-C8 alkyl and C1-C8 alkoxy groups. These compounds are gastrin and/or CCK-B receptor antagonists.

  式 I 的苯并二氮杂卓衍生物或其药学上可接受的盐： 其中 (a) R1 是-CH2CHOH(CH2)aR4 或酮基 -CH2CO(CH2)aR5，其中 a 是 0 或 1，R4 和 R5 选自碳原子数不超过 8 的烷基； (b) R2 和 R3 独立地选自具有 5 或 6 个环原子的任选取代的单环芳香族羰基和杂环残基， 其中 1、2 或 3 个环原子可以是杂原子，任选取代基选自卤素原子和羟基、氨基、硝基、 羧酸基、羧酰胺基和氰基以及烷基、烷氧基、烷基氨基和二烷基氨基，其中烷基 或每个烷基最多为 8 个碳原子；以及 (c) W 和 X 分别选自卤素、氢原子、C1-C8 烷基和 C1-C8 烷氧基。 这些化合物是胃泌素和/或 CCK-B 受体拮抗剂。
• Street, Jonathan D.; Baradarani, M. Mehdi; Beddoes, Roy L., Journal of Chemical Research, Miniprint, 1987, # 5, p. 1247 - 1285
  作者：Street, Jonathan D.、Baradarani, M. Mehdi、Beddoes, Roy L.、Mills, Owen S.、Joule, John A.

  DOI：——

  日期：——
• BENZODIAZEPIN DERIVATIVES USEFUL AS CCK-RECEPTOR ANTAGONISTS
  申请人：YAMANOUCHI PHARMACEUTICAL CO., LTD.

  公开号：EP0628033B1

  公开（公告）日：2003-07-23
• US5688943A
  申请人：——

  公开号：US5688943A

  公开（公告）日：1997-11-18
• US5962451A
  申请人：——

  公开号：US5962451A

  公开（公告）日：1999-10-05