7,8-dihydro-6H-cyclopentaquinoline | 7193-31-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7,8-dihydro-6H-cyclopentaquinoline
• 英文别名: 6,7-Trimethylenchinolin；7,8-Dihydro-6H-cyclopentachinolin；7,8-dihydro-6H-cyclopenta[g]quinoline；7,8-Dihydro-6H-cyclopenta[g]chinolin；7,8-dihydro-6H-cyclopenta[g]quinoline
• CAS: 7193-31-9
• 化学式: C₁₂H₁₁N
• mdl: MFCD18803448
• 分子量: 169.226
• InChiKey: ZZZPCMFPLCPJPY-UHFFFAOYSA-N

物化性质

• 熔点：
  79.5-81 °C
• 沸点：
  168 °C(Press: 12 Torr)
• 密度：
  1.160±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  7,8-dihydro-6H-cyclopentaquinoline 在 氢氧化钾 、 potassium permanganate 作用下， 生成 6,7-喹啉二甲酸
  参考文献：
  名称：

  Lindner et al., Monatshefte fur Chemie, 1939, vol. 72, p. 335,339

  摘要：

  DOI：
• 作为产物：
  描述：

  5-氨基茚旦 以2%的产率得到
  参考文献：
  名称：

  MARKGRAF J. H.; ANTIN J. H.; WALKER F. J.; BLATCHLY R. A., J. ORG. CHEM., 1979, 44, NO 18, 3261-3263

  摘要：

  DOI：

文献信息

• Rh^III-Catalyzed Direct C8-Arylation of Quinoline<i>N</i>-Oxides using Diazonaphthalen-2(1<i>H</i>)-ones: A Practical Approach towards 8-aza BINOL
  作者：Bidhan Ghosh、Aniruddha Biswas、Soumen Chakraborty、Rajarshi Samanta

  DOI：10.1002/asia.201800462

  日期：2018.9.4

  An efficient RhIII‐catalyzed redox‐neutral method for the direct C8‐arylation of quinoline N‐oxides using diazonaphthalen‐2(1H)‐one as coupling partner has been demonstrated. The developed method is simple, scalable and straightforward with a wide range of substrate scope. The applicative potential was extended with a late‐stage functionalization and straightforward synthesis of 8‐azaBINOL derivative

  已经证明了一种有效的Rh III催化的氧化还原中性方法，该方法使用重氮萘2（1 H）-one作为偶合配偶体直接对喹啉N-氧化物进行C8芳基化。所开发的方法简单，可扩展且简单，具有广泛的基板范围。通过后期功能化和直接合成8-azaBINOL衍生物可以扩大应用潜力。在进行初步的对照研究后，提出了一个合理的反应途径。
• FUSED HETEROCYCLIC COMPOUNDS AND THROMBOPOIETIN RECEPTOR ACTIVATORS
  申请人：Shigeta Yukihiro

  公开号：US20120209005A1

  公开（公告）日：2012-08-16

  Fused heterocyclic compounds useful for prevention, treatment or improvement of diseases against which activation of the thrombopoietin receptor is effective are provided. A compound represented by the formula (I) (wherein R 1 is an aryl group fused to a saturated ring or the like, A, B, L 1 , R 2 , L 2 , L 3 , Y, L 4 , R 3 and X are defined in the description), a tautomer, prodrug or a pharmaceutically acceptable salt of the compound or a solvate thereof.

  提供了对激活血小板生成素受体有效的疾病的预防、治疗或改善有用的融合杂环化合物。代表式(I)的化合物（其中R1是与饱和环或类似物融合的芳基，A、B、L1、R2、L2、L3、Y、L4、R3和X在描述中有定义），该化合物的互变异构体、前药或药用可接受的盐或其溶剂化物。
• Cyclopropyl Substituted Metallocene Catalysts
  申请人：ExxonMobil Chemical Patents Inc.

  公开号：US20150025207A1

  公开（公告）日：2015-01-22

  This invention relates to a novel group 2, 3 or 4 transition metal metallocene catalyst compound having at least one arenyl ligand substituted with: 1) a cyclopropyl group and, optionally, 2) at least one other group, such as a hydrocarbyl, a heteroatom or a heteroatom containing group.

  本发明涉及一种新型的2、3或4族过渡金属茂金属催化剂化合物，其至少具有一个芳基配体，该配体被取代为：1）环丙基基团，可选地，2）至少一个其他基团，例如烃基，杂原子或含杂原子的基团。
• Copper-Catalyzed Direct, Regioselective Arylamination of <i>N</i>-Oxides: Studies To Access Conjugated π-Systems
  作者：Aniruddha Biswas、Ujjwal Karmakar、Shiny Nandi、Rajarshi Samanta

  DOI：10.1021/acs.joc.7b01343

  日期：2017.9.1

  An efficient copper(I)-catalyzed direct regioselective arylamination of various heterocyclic N-oxides was achieved successfully under redox-neutral conditions using anthranils as arylaminating reagents. The developed protocol is simple, straightforward, and economic with a broad range substrate scope. The dual functional groups in the final molecules were utilized to construct structurally and functionally diverse nitrogen-containing organic x-conjugated systems.
• Inverse-electron-demanddiels-alder reactions of condensed pyridazines VI: Ring transformations of pyrido[2,3-d]pyridazine intog-fused quinolines
  作者：N. Haider、W. Staschek

  DOI：10.1007/bf00812249

  日期：1995.2

  A series of g-annelated quinolines was synthesized, employing pyrido[2,3-d]pyridazine as an azadiene in inverse-electron-demand Diels-Alder reactions with electron-rich dienophiles (enamines and a ketene-N,g-acetal). In cases where isomer mixtures were obtained, NOE difference spectroscopy was used for structural assignment.