6,7-Dihydroxytryptamine | 50584-06-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 6,7-Dihydroxytryptamine
• 英文别名: 3-(2-aminoethyl)-1H-indole-6,7-diol
• CAS: 50584-06-0
• 化学式: C₁₀H₁₂N₂O₂
• 分子量: 192.217
• InChiKey: JPQILYNPNMIPHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  82.3
• 氢给体数：
  4
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6,7-Dihydroxytryptamine 在 三乙胺 作用下， 以 甲醇 为溶剂， 生成 pyrrolo<4,3,2-de>-quinoline-7,8-dione
  参考文献：
  名称：

  吡咯烷氨基醌及其促红素原连接衍生物的便捷合成

  摘要：

  描述了设计用于改善细胞摄取的1-4，吡咯烷氨基醌生色团及其与促红细胞素载体连接的衍生物的合成。

  DOI：

  10.1016/s0040-4039(00)73118-2
• 作为产物：
  描述：

  2-(6,7-Bis-benzyloxy-1H-indol-3-yl)-ethylamine 在 钯 barium sulfate 、 氢气 作用下， 生成 6,7-Dihydroxytryptamine
  参考文献：
  名称：

  吡咯烷氨基醌及其促红素原连接衍生物的便捷合成

  摘要：

  描述了设计用于改善细胞摄取的1-4，吡咯烷氨基醌生色团及其与促红细胞素载体连接的衍生物的合成。

  DOI：

  10.1016/s0040-4039(00)73118-2

文献信息

• CONJUGATED ANTI-MICROBIAL COMPOUNDS AND CONJUGATED ANTI-CANCER COMPOUNDS AND USES THEREOF
  申请人：PONO CORPORATION

  公开号：US20150150995A1

  公开（公告）日：2015-06-04

  Disclosed herein are synthesis methods for generation of conjugated anti-microbial compounds and conjugated anti-cancer compounds. Several embodiments, related to the uses of such compounds in the treatment of infections, in particular those caused by drug-resistant bacteria. Some embodiments relate to targeting cancer based on the metabolic signature of tumor cells.

  本文公开了合成共轭抗微生物化合物和共轭抗癌化合物的方法。其中几种实施例与上述化合物在治疗感染方面的应用有关，特别是那些由耐药细菌引起的感染。一些实施例涉及基于肿瘤细胞代谢特征的癌症治疗。
• TARGET-DIRECTED BIOSYNTHESIS OF PLANT METABOLITES
  申请人：Naprogenix, Inc.

  公开号：US20160040176A1

  公开（公告）日：2016-02-11

  Certain embodiments of the invention provide a method comprising: a) transforming cells from a selected plant with a vector comprising a gene encoding a heterologous target protein, to obtain transgenic primary plant cells, wherein the selected plant is from a species that produces activators or inhibitors of the heterologous target protein; b) mutagenizing an explant obtained from the transgenic primary plant cells to form mutagenized transgenic cells; and c) exposing the mutagenized transgenic cells to a compound, wherein mutagenized transgenic cells that overproduce one or more activators or inhibitors of the heterologous target protein, as compared to a non-mutant transgenic plant cell from the same species, survive; and wherein mutagenized transgenic cells that do not overproduce one or more activators or inhibitors of the heterologous target protein, as compared to a non-mutant transgenic plant cell from the same species, die. Certain embodiments of the invention also provide plant cells prepared by the methods described herein.
• US9758788B2
  申请人：——

  公开号：US9758788B2

  公开（公告）日：2017-09-12
• [EN] CONJUGATED ANTI-MICROBIAL COMPOUNDS AND CONJUGATED ANTI-CANCER COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS ANTIMICROBIENS CONJUGUÉS ET COMPOSÉS ANTICANCÉREUX CONJUGUÉS ET LEURS UTILISATIONS
  申请人：PONO CORP

  公开号：WO2014026143A1

  公开（公告）日：2014-02-13

  Disclosed herein are synthesis methods for generation of conjugated anti-microbial compounds and conjugated anti-cancer compounds. Several embodiments, related to the uses of such compounds in the treatment of infections, in particular those caused by drug-resistant bacteria. Some embodiments relate to targeting cancer based on the metabolic signature of tumor cells.
• Convenient syntheses of pyrroloiminoquinone and its lexitropsin-linked derivative
  作者：Huiying Wang、Naim H. Al-Said、J.William Lown

  DOI：10.1016/s0040-4039(00)73118-2

  日期：1994.6

  The syntheses of 1–4, pyrroloiminoquinone chromophore and its lexitropsin carrier linked derivative designed to improved cellular uptake are described.

  描述了设计用于改善细胞摄取的1-4，吡咯烷氨基醌生色团及其与促红细胞素载体连接的衍生物的合成。