6-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,5,7-trimethoxychromen-4-one | 154662-04-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 6-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,5,7-trimethoxychromen-4-one
• 英文别名: pulicarin；3,5,7,40-tetramethyl ether quercetagetin；6-Hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-3,5,7-trimethoxy-chromen-4-on；Quercetagetin 3,5,7,4'-tetramethyl ether
• CAS: 154662-04-1
• 化学式: C₁₉H₁₈O₈
• 分子量: 374.347
• InChiKey: VZPASGPLDDVYCL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  6-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,5,7-trimethoxychromen-4-one 生成 3'-Hydroxy-3,5,6,7,4'-pentamethoxy-flavon
  参考文献：
  名称：

  HORIE, TOKUNARU;KAWAMURA, YASUHIKO;TSUKAYAMA, MASAO;YOSHIZAKI, SHIRO, CHEM. AND PHARM. BULL., 37,(1989) N, C. 1216-1220

  摘要：

  DOI：
• 作为产物：
  描述：

  3-benzyloxy-4-methoxy-benzoic acid-anhydride 在 盐酸 、 溶剂黄146 、 sodium-<3-benzyloxy-4-methoxy benzoate> 作用下， 生成 6-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,5,7-trimethoxychromen-4-one
  参考文献：
  名称：

  Goel et al., Journal of the Chemical Society, 1956, p. 1369

  摘要：

  DOI：

文献信息

• Structure−Activity Requirements for Flavone Cytotoxicity and Binding to Tubulin
  作者：John A. Beutler、Ernest Hamel、Arnold J. Vlietinck、Achiel Haemers、Padinchare Rajan、James N. Roitman、John H. Cardellina、Michael R. Boyd

  DOI：10.1021/jm970842h

  日期：1998.6.1

  A series of 79 flavones related to centaureidin (3,6,4'-trimethoxy-5,7,3'-trihydroxyflavone 1) was screened for cytotoxicity in the NCI in vitro 60-cell line human tumor screen. The resulting cytotoxicity profiles of these flavones were compared for degree of similarity to the profile of 1. Selected compounds were further evaluated with in vitro assays of tubulin polymerization and [H-3]colchicine binding to tubulin. Maximum potencies for tubulin interaction and production of differential cytotoxicity profiles characteristic of 1 were observed only with compounds containing hydroxyl substituents at C-3' and C-5 and methoxyl groups at C-3 and C-4'.
• Horie Tokunaru, Tominaga Hideaki, Yoshida Isao, Kawamura Yasuhiko, Bull. Chem. Soc. Jap., 66 (1993) N 3, S 877-881
  作者：Horie Tokunaru, Tominaga Hideaki, Yoshida Isao, Kawamura Yasuhiko

  DOI：——

  日期：——
• Flavonoid pulicarpin from Pulicaria salviifolia and its hypolipidemic activity
  作者：G. V. Sagitdinova、K. A. Éshbakova、Z. A. Khushbaktova、V. M. Malikov、V. Olimov

  DOI：10.1007/bf00630242

  日期：1992.5
• [EN] DRUGS FROM SUBSTITUTED PHENYL CINNAMYL KETONES<br/>[FR] MÉDICAMENTS OBTENUS À PARTIR DE PHÉNYL CINNAMYL CÉTONES SUBSTITUÉES
  申请人：NANYANG POLYTECHNIC

  公开号：WO2016153432A1

  公开（公告）日：2016-09-29

  The present invention relates to substituted phenyl cinnamyl ketones of Formula (I) for use in therapy: wherein R1 to R11 are defined as described in the specification, or a pharmaceutically acceptable salt, tautomer(s), solvate or polymorph thereof, that are used in the treatment on RNA virus related infections. The present invention also relates to use of the compounds as described in the specification for the manufacture of a medicament in the treatment of a disease associated with RNA virus infections. The present invention also relates a method of preventing or treating a disease associated with a RNA virus related infection comprising administering to a subject in need of treatment a compound as described in the specification, or a pharmaceutically acceptable salt thereof.
• Goel et al., Journal of the Chemical Society, 1956, p. 1369
  作者：Goel et al.

  DOI：——

  日期：——