1-Chloro-heptadec-2-yn-4-ol | 220344-52-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Chloro-heptadec-2-yn-4-ol
• CAS: 220344-52-5
• 化学式: C₁₇H₃₁ClO
• 分子量: 286.886
• InChiKey: BDJCGLGVMAAYDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.29
• 重原子数：
  19.0
• 可旋转键数：
  12.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  20.23
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  1-Chloro-heptadec-2-yn-4-ol 在 咪唑 作用下， 生成 (4S,5S)-4-[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-hydroxy-ethyl]-3-methylene-5-tridecyl-dihydro-furan-2-one
  参考文献：
  名称：

  Efficient total syntheses of (±)protolichesterinic acid and (±)rocellaric acid via tungsten-π-allyl complexes

  摘要：

  Total syntheses of racemic protolichesterinic acid (1) and rocellaric add (2) were achieved with the use of tungsten-pi-allyl complex in the key step. In this synthetic route, compounds 1 and 2 were prepared in four and six steps respectively starting from readily available chloropropargyl derivatives. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)02146-7
• 作为产物：
  描述：

  肉豆蔻醛 、 3-氯丙炔 在 正丁基锂 作用下， 以80%的产率得到1-Chloro-heptadec-2-yn-4-ol
  参考文献：
  名称：

  Efficient total syntheses of (±)protolichesterinic acid and (±)rocellaric acid via tungsten-π-allyl complexes

  摘要：

  Total syntheses of racemic protolichesterinic acid (1) and rocellaric add (2) were achieved with the use of tungsten-pi-allyl complex in the key step. In this synthetic route, compounds 1 and 2 were prepared in four and six steps respectively starting from readily available chloropropargyl derivatives. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)02146-7