ethyl (Z)-2-[hydroxy(phenyl)methyl]-3-(2-methylphenyl)prop-2-enoate | 1020062-24-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: ethyl (Z)-2-[hydroxy(phenyl)methyl]-3-(2-methylphenyl)prop-2-enoate
• CAS: 1020062-24-1
• 化学式: C₁₉H₂₀O₃
• 分子量: 296.366
• InChiKey: LPMCBQCZKQJSLO-LGMDPLHJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  、 苯甲醛 在 三氟化硼乙醚 、 氯化铵 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 生成 ethyl (2E)-2-[hydroxy(phenyl)methyl]-3-(2-methylphenyl)acrylate 、 ethyl (Z)-2-[hydroxy(phenyl)methyl]-3-(2-methylphenyl)prop-2-enoate
  参考文献：
  名称：

  Vicinal Functionalization of Propiolate Esters via a Tandem Catalytic Carbocupration−Mukaiyama Aldol Reaction Sequence

  摘要：

  The vicinal functionalization of propiolate esters via a tandem catalytic carbocupration-Mukaiyama aldol reaction sequence has been investigated. It has been shown that catalyst loadings as low as 8 mol % readily allow for good yields and excellent diastereoselectivities (>20:1) for a series of Grignard reagents and aldehydes.

  DOI：

  10.1021/ol800373g

文献信息

• Vicinal Functionalization of Propiolate Esters via a Tandem Catalytic Carbocupration−Mukaiyama Aldol Reaction Sequence
  作者：Amanda J. Mueller、Michael P. Jennings

  DOI：10.1021/ol800373g

  日期：2008.4.1

  The vicinal functionalization of propiolate esters via a tandem catalytic carbocupration-Mukaiyama aldol reaction sequence has been investigated. It has been shown that catalyst loadings as low as 8 mol % readily allow for good yields and excellent diastereoselectivities (>20:1) for a series of Grignard reagents and aldehydes.