9-Aminodecanoic Acid | 65706-63-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 9-Aminodecanoic Acid
• 英文别名: 9-Amino-decansaeure；9-Amino-decanoic acid
• CAS: 65706-63-0
• 化学式: C₁₀H₂₁NO₂
• 分子量: 187.282
• InChiKey: FWPKWVUFQDXPBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  13
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  10-溴代癸酸甲酯 在 palladium on activated charcoal 氢氧化钾 、 sodium tetrahydroborate 、 sodium azide 、 2-硝基苯基丝氰酸酯 、 四丁基溴化铵 、 氢溴酸 、 氢气 、 双氧水 、 甲基三辛基氯化铵 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 25.0~110.0 ℃ 、101.33 kPa 条件下， 反应 45.75h， 生成 9-Aminodecanoic Acid
  参考文献：
  名称：

  Cyclization of 9-substituted decanoic acid derivatives to 9-decanolide and 9-decanolactam

  摘要：

  Several standard and some novel cyclization reactions have been applied to 9-substituted decanoic acids to establish which are the optimum procedrues for lactonization and lactamization at 80-degrees-C under identical high-dilution conditions. The methods of Galli-Mandolini and Kellogg (cyclization of 9-bromodecanoate ion), Gerlach (cyclization of S-2-pyridyl 9-hydroxydecanethioate in the presence of AgClO4), and Yamaguchi (activation of the carboxyl group as a mixed with anhydride) in the presence of an excess of DMAP appear to be the most useful for the preparation of the 10-membered lactone, phoracantolide I, under these conditions. Analogously, treatment of S-2-pyridyl 9-azidodecanethioate with Sn(SePh)3-afforded the best yield of the 10-membered lactam. The mixed anhydrides RCOOCOAr (Ar = 2,4,6-trichlorophenyl) are more reactive than thioesters RCOSPy (Py = 2-pyridyl) with benzyl alcohol or benzylamine; it is confirmed that the addition of DMAP activates the reaction of alcohols with mixed anhydrides much more than with pyridyl thioesters, while the addition of Ag+ strongly activates RCOSPy in relation to either RCOOCOAr or RCOOSO2Mes.

  DOI：

  10.1021/jo00017a027

文献信息

• [EN] DRUG CONJUGATES<br/>[FR] CONJUGUÉS DE MÉDICAMENT
  申请人：UNIV MISSOURI

  公开号：WO2009158633A1

  公开（公告）日：2009-12-30

  Conjugated compounds comprising a therapeutic or diagnostic agent linked to a substrate for a cell membrane transporter or receptor by lipophilic linker are provided.

  提供了包含治疗或诊断药物与细胞膜转运体或受体的底物通过亲脂性连接剂连接的共轭化合物。
• An active energy ray curable composition comprised of a maleimide derivative and a method for curing the said curable composition
  申请人：DAINIPPON INK AND CHEMICALS, INC.

  公开号：EP0878482A1

  公开（公告）日：1998-11-18

  Objects of the present invention are the provision of an active energy ray curable composition which can be cured in the absence of a photoinitiator, and which can also be cured at practical light intensities and irradiating energy, and a method for curing the said curable composition; in which the composition comprises a maleimide derivative represented by formula (1): wherein m and n each represent an integer of 1 to 5, and the total of m and n is 6 or smaller, R11 and R12 each represent a linking group selected from the group consisting of ① an alkylene group, ② an alicyclic group, ③ an arylalkylene group, and ④ a cycloalkylalkyene group, G1 and G2 each represent an ester linkage selected from the group consisting of -COO- and - OCO-, R2 represents a linking chain having an average molecular weight of 100 to 100,000 selected from the group consisting of (A) a (poly)ether linking chain and (B) a (poly)ester linking chain, in which at least one organic group selected from the group consisting of ① a straight chain alkylene group, ② a branched alkylene group, ③ an alkylene group having a hydroxyl group, ④ an alicyclic group, ⑤ an aryl group, and ⑥ an arylalkylene group is connected via at least one linkage selected from the group consisting of (a) an ether linkage and (b) an ester linkage.

  本发明的目的是提供一种在没有光引发剂的情况下也能固化，并能在实际光强度和辐照能量下固化的活性能量射线固化组合物，以及固化上述固化组合物的方法；其中，该组合物包括由式（1）表示的马来酰亚胺衍生物： 其中 m 和 n 分别代表 1 至 5 的整数，且 m 和 n 的总和为 6 或更小、 R11 和 R12 各代表一个连接基团，该连接基团选自①亚烷基、②脂环基、③芳基亚烷基和④环烷基炔基、 G1 和 G2 分别代表选自 -COO- 和 -OCO- 组成的组的酯连接、 R2 代表平均分子量为 100 至 100,000 的连接链，选自由 (A) (多)醚连接链和 (B) (多)酯连接链组成的组，其中至少有一个有机基团选自由以下组成的组 ① 直链亚烷基、支链亚烷基、③具有羟基的亚烷基、④脂环族基团、⑤芳基和⑥芳烷基，其中至少一个有机基团通过选自 (a) 醚键和 (b) 酯键的一种连接方式连接。
• RESIN COMPOSITION, COMPOSITION FOR SOLDER RESIST, AND CURED ARTICLE OBTAINED THEREFROM
  申请人：Nippon Kayaku Kabushiki Kaisha

  公开号：EP1416003A1

  公开（公告）日：2004-05-06

  A resin composition which is excellent in photosensitively and developability, gives a cured article excellent in flexibility, soldering heat resistance, resistance to thermal deterioration, and resistance to electroless gold plating, and is suitable especially for use in forming solder resists and interlayer dielectrics. Theresincompositionischaracterized by containing an oligomer (A) obtained by reacting the following ingredients (a) to (d) : an epoxy resin having at least two epoxy groups per molecule, a compound having two hydroxy groups and one carboxy group per molecule, a carboxy group per molecule, a carboxylated rubbery polymer, and a monobasic acid having an unsatuated group.

  一种树脂组合物，具有优异的光敏性和显影性，固化物具有优异的柔韧性、耐焊接热 性、耐热劣化性和耐无电解镀金性，特别适用于形成阻焊层和层间电介质。该树脂组合物的特点是含有一种低聚物 (A)，该低聚物是由以下成分 (a) 至 (d) 反应而成：一种环氧树脂，其每个分子至少有两个环氧基团；一种化合物，其每个分子有两个羟基和一个羧基；一种羧基橡胶聚合物，其每个分子有一个羧基；以及一种单碱基酸，其具有一个未饱和基团。
• MALEIMIDO-BEARING COMPOUNDS, RESIN COMPOSITIONS CONTAINING THE SAME AND CURED ARTICLES THEREOF
  申请人：Nippon Kayaku Kabushiki Kaisha

  公开号：EP1460092A1

  公开（公告）日：2004-09-22

  The present invention provides (meth)acrylate compounds bearing a specific maleimide group and resin compositions containing said compounds that can be cured by irradiation of light in a practical dose even when a photoinitiator is not used or used in a smaller amount than that of the prior art, and cured articles of the resin compositions.

  本发明提供了带有特定马来酰亚胺基团的（甲基）丙烯酸酯化合物和含有上述化合物的树脂组合物，即使在不使用光引发剂或使用量少于现有技术的情况下，这些化合物也能通过实用剂量的光照射固化，本发明还提供了树脂组合物的固化物。
• Water compatible energy curable compositions containing maleimide derivatives
  申请人：Sun Chemical Corporation

  公开号：EP1666504A1

  公开（公告）日：2006-06-07

  Active water compatible energy curable compositions comprised of maleimide derivatives, water compatible resins and water which are capable of curing at a practical intensity and energy level and a method for curing same.

  由马来酰亚胺衍生物、水相容性树脂和水组成的活性水相容性能量固化组合物，能以实用的强度和能量水平固化，以及固化方法。