methyl 2-(4-fluorophenyl)-4-oxo-4H-chromene-3-carboxylate | 1391042-54-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: methyl 2-(4-fluorophenyl)-4-oxo-4H-chromene-3-carboxylate
• 英文别名: methyl 4-oxo-2-(4-fluorophenyl)-4H-chromene-3-carboxylate；Methyl 2-(4-fluorophenyl)-4-oxochromene-3-carboxylate
• CAS: 1391042-54-8
• 化学式: C₁₇H₁₁FO₄
• 分子量: 298.27
• InChiKey: DSPPUPHYYJSRHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methyl 2-(4-fluorophenyl)-4-oxo-4H-chromene-3-carboxylate 在 菲啶 、 diiodo(p-cymene)ruthenium(II) dimer 、 samarium(III) trifluoromethanesulfonate 、 氢气 作用下， 以 乙酸乙酯 为溶剂， 20.0~50.0 ℃ 、5.52 MPa 条件下， 反应 24.08h， 生成
  参考文献：
  名称：

  通过 Retro-Oxa-Michael 加成实现的动态动力学分辨率对 2,3-二取代黄烷酮进行不对称转移氢化：三个连续立体中心的构建

  摘要：

  通过动态动力学拆分和逆氧-迈克尔加成的结合，开发了一种钌催化的 2,3-二取代黄烷酮的不对称转移氢化，用于在碱性条件下构建三个连续的立体中心，从而使手性黄烷醇具有优异的对映选择性和非对映选择性。该反应通过碱催化的逆氧-迈克尔加成同时消旋两个立体中心与高度对映选择性的酮转移氢化步骤进行。在不损失活性和对映选择性的情况下，可以在克级实现不对称转移氢化。

  DOI：

  10.1021/acs.joc.2c00418
• 作为产物：
  描述：

  2-[3-(4-fluorophenyl)propynoyl]phenol 在 三丁基膦 、 三乙胺 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 2.08h， 生成 methyl 2-(4-fluorophenyl)-4-oxo-4H-chromene-3-carboxylate
  参考文献：
  名称：

  A concise total synthesis of biologically active frutinones via tributylphosphine-catalyzed tandem acyl transfer-cyclization

  摘要：

  A concise and step-economical total synthesis of biologically active frutinones has been achieved. Tributylphosphine (PBu3) efficiently induced the tandem acyl transfer-cyclization of carbonates 5 to afford 3-methoxycarbonylflavone derivatives 4 in excellent yields. Finally, concomitant deprotection and lactonization under acidic conditions furnished the desired frutinones A (1a), B (1b), and the proposed structure of frutinone C (1c). (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.03.073

文献信息

• Alcohol Mediated Synthesis of 4-Oxo-2-aryl-4<i>H</i>-chromene-3-carboxylate Derivatives from 4-Hydroxycoumarins
  作者：Manoj R. Zanwar、Mustafa J. Raihan、Sachin D. Gawande、Veerababurao Kavala、Donala Janreddy、Chun-Wei Kuo、Ram Ambre、Ching-Fa Yao

  DOI：10.1021/jo301044y

  日期：2012.8.3

  The unusual alcohol mediated formation of 4-oxo-2-aryl-4H-chromene-3-carboxylate (flavone-3-carboxylate) derivatives from 4-hydroxycoumarins and β-nitroalkenes in an alcoholic medium is described. The transformation occurs via the in situ formation of a Michael adduct, followed by the alkoxide ion mediated rearrangement of the intermediate. The effect of the different alcohol and nonalcohol media on

  这种不寻常的醇介导的4-氧代-2-芳基-4-的形成ħ色烯-3-羧酸甲酯（黄酮-3-羧酸）衍生物由4-羟基香豆素和β-硝基烯烃在醇介质进行说明。该转化通过原位形成迈克尔加合物而发生，随后是醇盐离子介导的中间体重排。研究了不同醇和非醇介质对反应的影响。
• One-pot synthesis of 2-aryl-3-alkoxycarbonyl chromones through a cascade Lewis acid-catalyzed aldehyde olefination/oxa-Michael addition/oxidation
  作者：Ningning Wang、Shuying Cai、Chao Zhou、Ping Lu、Yanguang Wang

  DOI：10.1016/j.tet.2012.11.008

  日期：2013.1

  were effectively constructed from aryl aldehydes and 3-(2-(methoxymethoxy)phenyl)propiolates via a cascade Lewis acid catalyzed phenol ether deprotection/aldehyde olefination/intramolecular oxa-Michael addition reaction, and a sequential oxidation. This four-step reaction could be conducted in one-pot with high atom efficiency.

  通过级联路易斯酸催化的酚醚脱保护/醛烯化/分子内氧杂-迈克尔加成反应和顺序氧化反应，由芳基醛和3-（2-（甲氧基甲氧基）苯基）丙酸酯有效地构建了2-芳基-3-烷氧基羰基色酮。该四步反应可以在一个锅中以高原子效率进行。
• A concise total synthesis of biologically active frutinones via tributylphosphine-catalyzed tandem acyl transfer-cyclization
  作者：Masahito Yoshida、Koya Saito、Yuta Fujino、Takayuki Doi

  DOI：10.1016/j.tet.2014.03.073

  日期：2014.5

  A concise and step-economical total synthesis of biologically active frutinones has been achieved. Tributylphosphine (PBu3) efficiently induced the tandem acyl transfer-cyclization of carbonates 5 to afford 3-methoxycarbonylflavone derivatives 4 in excellent yields. Finally, concomitant deprotection and lactonization under acidic conditions furnished the desired frutinones A (1a), B (1b), and the proposed structure of frutinone C (1c). (C) 2014 Elsevier Ltd. All rights reserved.
• Asymmetric Transfer Hydrogenation of 2,3-Disubstituted Flavanones through Dynamic Kinetic Resolution Enabled by Retro-Oxa-Michael Addition: Construction of Three Contiguous Stereogenic Centers
  作者：Qing-Xian Xie、Li-Xia Liu、Zhou-Hao Zhu、Chang-Bin Yu、Yong-Gui Zhou

  DOI：10.1021/acs.joc.2c00418

  日期：2022.6.3

  A ruthenium-catalyzed asymmetric transfer hydrogenation of 2,3-disubstituted flavanones was developed for the construction of three contiguous stereocenters under basic conditions through a combination of dynamic kinetic resolution and retro-oxa-Michael addition, giving chiral flavanols with excellent enantioselectivities and diastereoselectivities. The reaction proceeded via a base-catalyzed retro-oxa-Michael

  通过动态动力学拆分和逆氧-迈克尔加成的结合，开发了一种钌催化的 2,3-二取代黄烷酮的不对称转移氢化，用于在碱性条件下构建三个连续的立体中心，从而使手性黄烷醇具有优异的对映选择性和非对映选择性。该反应通过碱催化的逆氧-迈克尔加成同时消旋两个立体中心与高度对映选择性的酮转移氢化步骤进行。在不损失活性和对映选择性的情况下，可以在克级实现不对称转移氢化。