diisopropyl (α-methylamino)benzylphosphonate | 42275-24-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物
• 英文名称: diisopropyl (α-methylamino)benzylphosphonate
• 英文别名: 1-di(propan-2-yloxy)phosphoryl-N-methyl-1-phenylmethanamine
• CAS: 42275-24-1
• 化学式: C₁₄H₂₄NO₃P
• 分子量: 285.323
• InChiKey: PNIFEGXWNQXVBD-UHFFFAOYSA-N

物化性质

• 沸点：
  366.2±35.0 °C(Predicted)
• 密度：
  1.062±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  diisopropyl (α-methylamino)benzylphosphonate 、 O,O-dipropyl phosphoroisothiocyanatidothioate 以 乙醚 为溶剂， 反应 1.0h， 以60%的产率得到1-[di(propan-2-yloxy)phosphoryl-phenylmethyl]-3-dipropoxyphosphinothioyl-1-methylthiourea
  参考文献：
  名称：

  Zimin, M. G.; Kamalov, R. M.; Cherkasov, R. A., Phosphorus and Sulfur and the Related Elements, 1982, vol. 13, p. 371 - 378

  摘要：

  DOI：

文献信息

• Zimin, M. G.; Burilov, A. R.; Islamov, R. G., Journal of general chemistry of the USSR, 1980, vol. 50, # 10, p. 1775 - 1781
  作者：Zimin, M. G.、Burilov, A. R.、Islamov, R. G.、Pominov, I. S.、Pudovik, A. N.

  DOI：——

  日期：——
• Reactions of  -Aminoalkylphosphonates with Iso(thio)cyanatophosphates(phosphonates, phosphinates). Synthesis of 1,3,4-Diazaphospholidines and 1,3,4-Oxaza(thiaza)phospholines
  作者：N. A. Khailova、A. A. Shaimardanova、G. M. Saakyan、T. A. Zyablikova、N. M. Azancheev、D. B. Krivolapov、A. T. Gubaidullin、I. A. Litvinov、R. Z. Musin、G. A. Chmutova、M. A. Pudovik、A. N. Pudovik

  DOI：10.1023/b:rugc.0000007644.95638.fc

  日期：2003.8

  Phenyl alpha-aminoalkylphosphonates add to phenyl iso(thio)cyanates to give saturated heterocycles, 1,3,4-diazaphospholidin-2-(thi)ones. The reaction of diphenyl (alpha-methylamino)benzylphosphonate with diethyl isothiocyanatophosphate involves initial formation of 1, 3,4-tiazaphospholidine-2-thiones containing exo- and endocyclic phosphorus atoms. These products are readily hydrolyzed in air, yielding diethyl isothiocyanatophosphate and phenyl hydrogen (alpha-methylamino)benzylphosphonate. The final products of the reaction of chloromethyl isocyanatophosphonates with aminoalkylphosphonates are 1,3,4-oxazaphospholines. Phenyl aminoalkylphosphonates react with chloromethyl isocyanatophosphonates to give saturated heterocycles, 1,3,4-diazaphospholidines, whereas with chloromethyl isothiocyanatophosphonates 1,3,4-thiazaphospholines are formed.
• Khailova, N. A.; Pudovik, M. A.; Pudovik, A. N., Russian Journal of General Chemistry, 1997, vol. 67, # 12, p. 1937 - 1938
  作者：Khailova, N. A.、Pudovik, M. A.、Pudovik, A. N.

  DOI：——

  日期：——
• ZIMIN M. G.; BURILOV A. R.; ISLAMOV R. G.; POMINOV I. S.; PUDOVIK A. N., ZH. OBSHCH. XIMII, 1980, 50, HO 10, 2203-2210
  作者：ZIMIN M. G.、 BURILOV A. R.、 ISLAMOV R. G.、 POMINOV I. S.、 PUDOVIK A. N.

  DOI：——

  日期：——
• ZIMIN, M. G.;KAMALOV, R. M.;CHERKASOV, R. A.;PUDOVIK, A. N., PHOSPH. AND SULFUR, 1982, 13, N 3, 371-378
  作者：ZIMIN, M. G.、KAMALOV, R. M.、CHERKASOV, R. A.、PUDOVIK, A. N.

  DOI：——

  日期：——