2-(4-chloro-benzenesulfonylamino)-4-methoxy-1-methyl-pyrimidinium-betaine | 857011-33-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(4-chloro-benzenesulfonylamino)-4-methoxy-1-methyl-pyrimidinium-betaine
• 英文别名: 2-(4-Chlor-benzolsulfonylamino)-4-methoxy-1-methyl-pyrimidinium-betain
• CAS: 857011-33-7
• 化学式: C₁₂H₁₂ClN₃O₃S
• 分子量: 313.765
• InChiKey: JFINLWPWKDNQKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.37
• 重原子数：
  20.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  73.55
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  2-(4-chloro-benzenesulfonylamino)-4-methoxy-1-methyl-pyrimidinium-betaine 在 氢氧化钾 、 乙醇 、 水 作用下， 生成 4-chloro-benzenesulfonic acid-(1-methyl-4-oxo-1,4-dihydro-pyrimidin-2-ylamide)
  参考文献：
  名称：

  Do Elderly Medicare Recipients Contact Physicians Appropriately?

  摘要：

  Objectives. This research identified characteristics of persons and their illness episodes that predict appropriate and inappropriate decisions to seek medical care.Methods. This study analyzes 1,292 health care decisions of 885 elderly members of an HMO in Los Angeles. Illness episodes are divided into three categories based on the expertise of a panel of 22 geriatricians, using a formal mathematical analysis derived from anthropological consensus theory. These categories are physician visit not recommended, physician visit recommended, and physician visit mandatory. Physician contact is regressed on a list of variables derived from Andersen's behavioral model separately for each group of episodes.Results. Although the variables indicating perceived seriousness and duration of the episode consistently predict the decision to contact a physician, regardless of whether that contact is considered appropriate by the geriatrician panel, the variables indicating other illness responses and predisposing personal attributes have less consistent patterns of significance.Discussion. The category of episodes (visit recommended) for which predisposing personal attributes figure most strongly in the treatment decision is the one for which there are no clear Cultural directives to action. Implications for health education and policy are drawn from the findings.

  DOI：

  10.1093/geronb/57.3.s187
• 作为产物：
  描述：

  2-氨基-4-甲氧基嘧啶 在 吡啶 、 氢氧化钾 、 ammonium hydroxide 作用下， 生成 2-(4-chloro-benzenesulfonylamino)-4-methoxy-1-methyl-pyrimidinium-betaine
  参考文献：
  名称：

  Do Elderly Medicare Recipients Contact Physicians Appropriately?

  摘要：

  Objectives. This research identified characteristics of persons and their illness episodes that predict appropriate and inappropriate decisions to seek medical care.Methods. This study analyzes 1,292 health care decisions of 885 elderly members of an HMO in Los Angeles. Illness episodes are divided into three categories based on the expertise of a panel of 22 geriatricians, using a formal mathematical analysis derived from anthropological consensus theory. These categories are physician visit not recommended, physician visit recommended, and physician visit mandatory. Physician contact is regressed on a list of variables derived from Andersen's behavioral model separately for each group of episodes.Results. Although the variables indicating perceived seriousness and duration of the episode consistently predict the decision to contact a physician, regardless of whether that contact is considered appropriate by the geriatrician panel, the variables indicating other illness responses and predisposing personal attributes have less consistent patterns of significance.Discussion. The category of episodes (visit recommended) for which predisposing personal attributes figure most strongly in the treatment decision is the one for which there are no clear Cultural directives to action. Implications for health education and policy are drawn from the findings.

  DOI：

  10.1093/geronb/57.3.s187