Z-Val-Thr(ψ^Me,Mepro)-Val-Thr(ψ^Me,Mepro)-Val-Thr(TBS)-OH | 820226-04-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Z-Val-Thr(ψ^Me,Mepro)-Val-Thr(ψ^Me,Mepro)-Val-Thr(TBS)-OH
• 英文别名: (2S,3R)-3-[tert-butyl(dimethyl)silyl]oxy-2-[[(2S)-3-methyl-2-[[(4S,5R)-2,2,5-trimethyl-3-[(2S)-3-methyl-2-[[(4S,5R)-2,2,5-trimethyl-3-[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]-1,3-oxazolidine-4-carbonyl]amino]butanoyl]-1,3-oxazolidine-4-carbonyl]amino]butanoyl]amino]butanoic acid
• CAS: 820226-04-8
• 化学式: C₄₇H₇₈N₆O₁₂Si
• 分子量: 947.255
• InChiKey: QLFCLIPTOIWGRP-ZVAKQWIASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  66
• 可旋转键数：
  20
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  231
• 氢给体数：
  5
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  Z-Val-Thr(ψ^Me,Mepro)-Val-Thr(ψ^Me,Mepro)-Val-Thr(TBS)-OH 在 palladium on activated charcoal 五氟苯基二苯基磷酸酯 、 氢气 、 N,N-二异丙基乙胺 作用下， 以 甲醇 、 乙腈 为溶剂， 反应 5.0h， 生成 (3S,6S,7R,12S,15R,18S,21S,22R)-15-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3,12,18-triisopropyl-7,9,9,22,24,24-hexamethyl-8,23-dioxa-1,4,10,13,16,19-hexaaza-tricyclo[19.3.0.0^6,10]tetracosane-2,5,11,14,17,20-hexaone
  参考文献：
  名称：

  Pseudoprolines as Removable Turn Inducers:  Tools for the Cyclization of Small Peptides

  摘要：

  The cyclization of small peptides which do not incorporate turn inducers is often difficult. We have developed a method involving the use of removable turn inducers, in the form of pseudoprolines, for the cyclization of difficult peptide sequences. The pseudoprolines induce a cisoid amide bond in the peptide backbone which facilitates cyclization. They are then readily removed to yield a cyclic peptide that does not contain any turn inducers.

  DOI：

  10.1021/jo0484732
• 作为产物：
  描述：

  Cbz-Val-Thr-OMe 在 palladium on activated charcoal N-甲基吗啉 、 lithium hydroxide 、 camphor-10-sulfonic acid 、 氢气 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 22.0h， 生成 Z-Val-Thr(ψ^Me,Mepro)-Val-Thr(ψ^Me,Mepro)-Val-Thr(TBS)-OH
  参考文献：
  名称：

  Pseudoprolines as Removable Turn Inducers:  Tools for the Cyclization of Small Peptides

  摘要：

  The cyclization of small peptides which do not incorporate turn inducers is often difficult. We have developed a method involving the use of removable turn inducers, in the form of pseudoprolines, for the cyclization of difficult peptide sequences. The pseudoprolines induce a cisoid amide bond in the peptide backbone which facilitates cyclization. They are then readily removed to yield a cyclic peptide that does not contain any turn inducers.

  DOI：

  10.1021/jo0484732

文献信息

• Pseudoprolines as Removable Turn Inducers:  Tools for the Cyclization of Small Peptides
  作者：Danielle Skropeta、Katrina A. Jolliffe、Peter Turner

  DOI：10.1021/jo0484732

  日期：2004.12.1

  The cyclization of small peptides which do not incorporate turn inducers is often difficult. We have developed a method involving the use of removable turn inducers, in the form of pseudoprolines, for the cyclization of difficult peptide sequences. The pseudoprolines induce a cisoid amide bond in the peptide backbone which facilitates cyclization. They are then readily removed to yield a cyclic peptide that does not contain any turn inducers.