1-(2,4-dihydroxy-phenyl)-3-(2-methoxy-phenyl)-propan-1-one | 858446-48-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1-(2,4-dihydroxy-phenyl)-3-(2-methoxy-phenyl)-propan-1-one
• 英文别名: 1-(2,4-Dihydroxy-phenyl)-3-(2-methoxy-phenyl)-propan-1-on；1-(2,4-Dihydroxyphenyl)-3-(2-methoxyphenyl)propan-1-one；1-(2,4-dihydroxyphenyl)-3-(2-methoxyphenyl)propan-1-one
• CAS: 858446-48-7
• 化学式: C₁₆H₁₆O₄
• 分子量: 272.301
• InChiKey: SHAGQUCFCYTPPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(2,4-dihydroxy-phenyl)-3-(2-methoxy-phenyl)-propan-1-one 、 alkaline earth salt of/the/ methylsulfuric acid 生成 7-acetoxy-3-(2-methoxy-benzyl)-2-methyl-chromen-4-one
  参考文献：
  名称：

  80.氰基马杜林及其衍生物的合成实验。第一部分3：5：7：2'：4'-五甲氧基黄烷

  摘要：

  DOI：

  10.1039/jr9330000288
• 作为产物：
  描述：

  2',4'-dihydroxy-2-methoxylchalcone 在 palladium on activated charcoal 、 氢气 作用下， 以 四氢呋喃 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 16.0h， 生成 1-(2,4-dihydroxy-phenyl)-3-(2-methoxy-phenyl)-propan-1-one
  参考文献：
  名称：

  New homoisoflavonoid analogues protect cells by regulating autophagy

  摘要：

  As a special group of naturally occurring flavonoids, homoisoflavonoids have been discovered as active components of several traditional Chinese medicines for nourishing heart and mind. In this study, twenty homoisoflavonoid analogues, including different substitution groups on rings A and B, as well as heteroaromatic B ring, were synthesized and evaluated for their cardioprotective and neuroprotective activities. In a H2O2-induced H9c2 cardiomyocytes injury assay, nine homoisoflavonoid analogues showed promising activities in the same level as the positive control, diazoxide. Six cardioprotective compounds with representative structure diversities were then evaluated for their neuroprotective effects on MPP+ induced SH-SY5Y cell injury model. Furthermore, autophagy inducing monodansylcadaverine (MDC) fluorescence staining methods and molecular docking studies indicated the action mechanism of these compounds may involve autophagy regulating via class I P13K signaling pathway. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2017.01.086