1-(2,6-二氟苯基)-3-(2-羟基苯基)丙烷-1,3-二酮 | 623944-98-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 中文名称: 1-(2,6-二氟苯基)-3-(2-羟基苯基)丙烷-1,3-二酮
• 英文名称: 3-(2,6-difluorophenyl)-1-(2-hydroxyphenyl)propane-1,3-dione
• 英文别名: 1-(2,6-Difluorophenyl)-3-(2-hydroxyphenyl)propane-1,3-dione
• CAS: 623944-98-9
• 化学式: C₁₅H₁₀F₂O₃
• 分子量: 276.239
• InChiKey: ZSHJKXPHRVVNID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  homoveratric anhydride 、 1-(2,6-二氟苯基)-3-(2-羟基苯基)丙烷-1,3-二酮 在 sodium hydride 作用下， 以 甲苯 为溶剂， 反应 4.0h， 以67%的产率得到3-(2,6-difluorobenzoyl)-2-(3,4-dimethoxybenzyl)[4H]benzopyran-4-one
  参考文献：
  名称：

  Reinvestigation of prototropic photochromism: 3-benzoyl-2-benzylchromones

  摘要：

  The synthesis of a series of new nine 3-benzoyl-2-benzylchromones is developed through a classical and an optimized Kostanecki-Robinson method involving an o-hydroxyphenyl-beta-diketone and an acid anhydride. The different spectrokinetic studies carried out in solution and in polymer matrixes have highlighted the main structure/photochromic parameters relationships and the influence of the medium on the photochromic properties. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(03)01211-0
• 作为产物：
  描述：

  2,6-二氟苯甲酰氯 在 吡啶 、 sodium hydride 作用下， 以 二甲基亚砜 为溶剂， 反应 1.5h， 生成 1-(2,6-二氟苯基)-3-(2-羟基苯基)丙烷-1,3-二酮
  参考文献：
  名称：

  Reinvestigation of prototropic photochromism: 3-benzoyl-2-benzylchromones

  摘要：

  The synthesis of a series of new nine 3-benzoyl-2-benzylchromones is developed through a classical and an optimized Kostanecki-Robinson method involving an o-hydroxyphenyl-beta-diketone and an acid anhydride. The different spectrokinetic studies carried out in solution and in polymer matrixes have highlighted the main structure/photochromic parameters relationships and the influence of the medium on the photochromic properties. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(03)01211-0

文献信息

• LUMINESCENT DIKETONATE POLYMERS
  申请人：Fraser Cassandra L.

  公开号：US20090137057A1

  公开（公告）日：2009-05-28

  The present invention provides in one aspect polymeric luminescent dye compounds having fluorescent properties, phosphorescent properties, or both fluorescent and phosphorescent properties.
• COMPOSITIONS AND METHODS FOR MAKING AND USING OXYGEN SENSING NANOFIBERS AND SCAFFOLDS
  申请人：University of Virginia Patent Foundation

  公开号：US20160041177A1

  公开（公告）日：2016-02-11

  To address the need for scaffold-based oxygen concentration monitoring, a single-component, self-referenced oxygen sensor was made into nanofibers. Electrospinning process parameters were tuned to produce a biomaterial scaffold with specific morphological features. The ratio of an oxygen sensitive phosphorescence signal to an oxygen insensitive fluorescence signal was calculated at each image pixel to determine an oxygenation value. A single component boron dye-polymer conjugate was chosen for additional investigation due to improved resistance to degradation in aqueous media compared to a dye polymer blend. Standardization curves show that in fully supplemented media, the fibers are responsive to dissolved oxygen concentrations less than 15 parts per million. Spatial and temporal ratiometric gradients were observed in vitro radiating outward from the center of a dense adherent cell grouping. Sensor activation in ischemia and cell transplant models in vivo show oxygenation decreases on the scale of minutes.
• US7955861B2
  申请人：——

  公开号：US7955861B2

  公开（公告）日：2011-06-07
• US9874566B2
  申请人：——

  公开号：US9874566B2

  公开（公告）日：2018-01-23
• [EN] LUMINESCENT DIKETONATE POLYMERS<br/>[FR] POLYMÈRES DE DICÉTONATE LUMINESCENTS
  申请人：UNIV VIRGINIA

  公开号：WO2007143209A2

  公开（公告）日：2007-12-13

  [EN] The present invention provides in one aspect polymeric luminescent dye compounds having fluorescent properties, phosphorescent properties, or both fluorescent and phosphorescent properties.
  [FR] La présente invention concerne, dans un aspect, des composés colorants luminescents polymères ayant des propriétés fluorescentes, des propriétés phosphorescentes, ou des propriétés à la fois fluorescentes et phosphorescentes.