(S)-1-(1'-amino-1'-phenylmethyl)cyclohexanol | 174195-97-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (S)-1-(1'-amino-1'-phenylmethyl)cyclohexanol
• 英文别名: 1-[(S)-amino(phenyl)methyl]cyclohexan-1-ol
• CAS: 174195-97-2
• 化学式: C₁₃H₁₉NO
• 分子量: 205.3
• InChiKey: QYZQCUZVVZWJDT-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(tert-butoxycarbonyl)phenylalanine ethyl ester 在 盐酸 、 magnesium 作用下， 以 溶剂黄146 为溶剂， 反应 19.0h， 生成 (S)-1-(1'-amino-1'-phenylmethyl)cyclohexanol
  参考文献：
  名称：

  Intramolecular vs. intermolecular induction in the diastereoselective catalytic reduction of enantiomerically pure ketones with borane in the presence of cyclic β-amino alcohols

  摘要：

  Asymmetric reduction of various enantiomerically pure ketones was carried out by using oxazaborolidine catalysts with a variety of achiral and chiral ligands. The efficiency of chiral 1,2-amino alcohols as well as the effect of the stereogenic centers in the substrate on the catalytic asymmetric reduction were studied. It was found that the corresponding secondary alcohols were obtained with extremely high stereoselectivities with the proper choice of chiral ligands although a considerably large double asymmetric induction was observed in some cases.

  DOI：

  10.1016/0957-4166(95)00404-1

文献信息

• Yaozhong, Jiang; Guilan, Liu; Jingen, Deng, Synthetic Communications, 1988, vol. 18, # 11, p. 1291 - 1298
  作者：Yaozhong, Jiang、Guilan, Liu、Jingen, Deng

  DOI：——

  日期：——