1-(β-1-D-glucopyranosyl)-5-(4-methylphenyl)-3-(2-pyrazinyl)-1H-1,2,4-triazole

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(β-1-D-glucopyranosyl)-5-(4-methylphenyl)-3-(2-pyrazinyl)-1H-1,2,4-triazole
• 英文别名: (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[5-(4-methylphenyl)-3-pyrazin-2-yl-1,2,4-triazol-1-yl]oxane-3,4,5-triol
• 化学式: C₁₉H₂₁N₅O₅
• 分子量: 399.406
• InChiKey: BCWLDWDYBQZQKR-RUEZSYAVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  147
• 氢给体数：
  4
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  3-(4-methylphenyl)-pyridin-2-yl-1,2,4-triazole 在 氢氧化钾 、 苄基三乙基氯化铵 、 sodium methylate 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 30.0h， 生成 1-(β-1-D-glucopyranosyl)-5-(4-methylphenyl)-3-(2-pyrazinyl)-1H-1,2,4-triazole
  参考文献：
  名称：

  Synthesis and antiviral activity of some new 1H-1,2,4-triazole derivatives

  摘要：

  A series of new 1H-1,2,4-triazole derivatives was synthesised and evaluated in vitro for activity against various DNA and RNA viruses. Compounds 1-benzyl-5-(4-methylphenyl)-3-(2-pyrazinyl)-1H-1,2,4-triazole 2b, 1-benzyl-5-(3-methylphenyl)-3-(2-pyrazinyl)-1H-1,2,4-triazole 2c and 1-[(2-hydroxyethoxy)methyl]-5-(3-methylphenyl)-3-(2-pyrazinyl)-1H-1,2,4-triazole 4h proved active against reovirus-1, and compounds 1-[(2-hydroxyethoxy)methyl]-5-phenyl-3-(2-pyrazinyl)-1H-1,2,4-triazole 4f and 1-[(2-hydroxyethoxy)methyl]-5-(3-methylphenyl-3-(2-pyrazinyl)-1H-1,2,4-triazole 4h against parainfluenza-3 virus, in Vero cells at concentrations that were 5- to 40-fold lower than the cytotoxic concentrations required to alter normal cell morphology.

  DOI：

  10.1016/0223-5234(94)90152-x