屈-1,2-二酮 | 2304-83-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 中文名称: 屈-1,2-二酮
• 英文名称: chrysene-1,2-dione
• 英文别名: Chrysen-chinon-(1,2)；1,2-chrysenequinone；chrysene-1,2-quinone；1,2-Chrysenedione
• CAS: 2304-83-8
• 化学式: C₁₈H₁₀O₂
• 分子量: 258.276
• InChiKey: KXQDINHHHLYVOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2914399090

反应信息

• 作为反应物：
  描述：

  屈-1,2-二酮 在 镍 氢气 作用下， 生成 1,2-Bis-phenylethyl-chrysen
  参考文献：
  名称：

  Ried,W.; Suarez-Rivero,E., Chemische Berichte, 1963, vol. 96, p. 1475 - 1477

  摘要：

  DOI：
• 作为产物：
  描述：

  2-羟基屈 在 sIBX 作用下， 以 四氢呋喃 为溶剂， 以42 %的产率得到屈-1,2-二酮
  参考文献：
  名称：

  通过稳定的 2-碘代苯甲酸 (SIBX) 制剂从羟基-PAHs 氧化合成邻苯二酚

  摘要：

  使用市售稳定的碘代苯甲酸 (SIBX)，可以方便地将多环芳族酚（PAP 或羟基-PAH）转化为相应的邻苯二酚。SIBX 提供了一种更安全且可商购的 IBX 替代品，并且在酚类氧化脱芳构化为邻醌的过程中显示出相同的选择性和相当或更好的收率，包括对醌的形成是可行的示例。这个邻-来自羟基所有位置的选择性允许通过二苯乙烯的光化学环化或铂催化的环异构化简单合成先决条件的羟基-PAH。后来的合成涉及四步序列，其中通过 Suzuki-Miyaura 交叉偶联制备适当取代的联苯，然后是 Corey-Fuchs 方案和通过催化量的 PtCl 2 进行环异构化。2-和4-甲基菲也是首次用该方法制备得到。

  DOI：

  10.1016/j.tet.2022.133144

文献信息

• Methods and compositions for detecting polynucleotide duplex damage and errors
  申请人：Barton K. Jacqueline

  公开号：US20050148772A1

  公开（公告）日：2005-07-07

  In accordance with the present invention there is provided a new class of sterically demanding metallo-intercalators. These compounds intercalate between bases in a duplex polynucleotide, but only where the bases are not fully complementary, for example, where there is a base-pair mismatch. The compounds are sufficiently sterically demanding that intercalation between bases in fully complementary duplexes does not occur to a significant degree. These mismatch intercalators are useful for detecting DNA and RNA defects, for diagnosing disorders characterized by the presence or increase in DNA and/or RNA defects, and for treating such disorders. Further, the compounds are capable of catalyzing photolytic cleavage of nucleic acids at relatively long wavelengths, and under normal sunlight.

  根据本发明，提供了一类新的立体位阻金属插入剂。这些化合物在双链多核苷酸中插入碱基，但仅在碱基不完全互补的情况下，例如，存在碱基对不匹配的情况下。这些化合物具有足够的立体位阻，使得在完全互补的双链中碱基之间的插入不会显著发生。这些不匹配插入剂可用于检测DNA和RNA缺陷，诊断其存在或增加的疾病，并用于治疗此类疾病。此外，这些化合物能够在相对较长的波长和正常阳光下催化核酸的光解裂。
• Process for producing liquid hydrocarbon
  申请人：STEEPER ENERGY APS

  公开号：US10150920B2

  公开（公告）日：2018-12-11

  A continuous process for converting carbonaceous material contained in one or more feedstocks into a liquid hydrocarbon product, said feedstocks including the carbonaceous material being in a feed mixture including one or more fluids, said fluids including water and further liquid organic compounds at least partly produced by the process in a concentration of at least 1% by weight, where the process comprises converting at least part of the carbonaceous material by pressurizing the feed mixture to a pressure in the range 250-400 bar; heating the feed mixture to a temperature in the range 370-450° C., and maintaining said pressurized and heated feed mixture in the desired pressure and temperature ranges in a reaction zone for a predefined time; cooling the feed mixture to a temperature in the range 25-200° C. and expanding the feed mixture to a pressure in the range of 1-70 bar, thereby causing the carbonaceous material to be converted to a liquid hydrocarbon product and separating from the converted feed mixture a fraction comprising liquid hydrocarbon product.

  一种将包含在一种或多种原料中的碳质材料转化为液态烃产品的连续工艺，所述原料包括碳质材料和一种或多种流体的进料混合物，所述流体包括水和至少部分由该工艺生产的进一步的液态有机化合物，其浓度至少为重量的1%，其中该工艺包括通过将进料混合物加压至250-400巴范围内的压力来转化至少部分碳质材料；将进料混合物加热至370-450℃范围内的温度、将所述加压和加热的进料混合物在所需压力和温度范围内保持在反应区内一段预定时间；将进料混合物冷却至 25-200 摄氏度范围内的温度，并将进料混合物膨胀至 1-70 巴范围内的压力，从而使碳质材料转化为液态烃产品，并从转化后的进料混合物中分离出含有液态烃产品的馏分。
• Process and apparatus for producing liquid hydrocarbon
  申请人：STEEPER ENERGY APS

  公开号：US10174260B2

  公开（公告）日：2019-01-08

  A continuous process for converting carbonaceous material contained in one or more feedstocks into a liquid hydrocarbon product, said feedstocks including the carbonaceous material being in a feed mixture including one or more fluids, said fluids including water and further liquid organic compounds at least partly produced by the process in a concentration of at least 1% by weight, where the process comprises converting at least part of the carbonaceous material by pressurising the feed mixture to a pressure in the range 250-400 bar; heating the feed mixture to a temperature in the range 370-450° C., and maintaining said pressurized and heated feed mixture in the desired pressure and temperature ranges in a reaction zone for a predefined time; cooling the feed mixture to a temperature in the range 25-200° C. and expanding the feed mixture to a pressure in the range of 1-70 bar, thereby causing the carbonaceous material to be converted to a liquid hydrocarbon product and separating from the converted feed mixture a fraction comprising liquid hydrocarbon product.

  一种将包含在一种或多种原料中的碳质材料转化为液态烃产品的连续工艺，所述原料包括碳质材料和一种或多种流体的进料混合物，所述流体包括水和至少部分由该工艺生产的进一步的液态有机化合物，其浓度至少为 1%（重量百分比），其中该工艺包括通过将进料混合物加压至 250-400 巴范围内的压力来转化至少部分碳质材料；将进料混合物加热至 370-450 摄氏度范围内的温度、将所述加压和加热的进料混合物在所需压力和温度范围内保持在反应区内一段预定时间；将进料混合物冷却至 25-200 摄氏度范围内的温度，并将进料混合物膨胀至 1-70 巴范围内的压力，从而使碳质材料转化为液态烃产品，并从转化后的进料混合物中分离出含有液态烃产品的部分。
• Detection and treatment of duplex polynucleotide damage
  申请人：California Institute of Technology

  公开号：US20030018020A1

  公开（公告）日：2003-01-23

  Duplex polynucleotides containing damage or errors are detected with hindered intercalating compounds which are capable of intercalating only in the presence of such damage or error. Conditions characterized by the presence of polynucleotide errors or damage are treated with such compounds that are capable of catalyzing polynucleotide cleavage with light. Suitable compound include compounds of the formula: Rh(R 1 )(R 2 )(R 3 ) 3+ where R 1 and R 2 are each independently aryl, heteroaryl, substituted aryl or substituted heteroaryl of 1 to 5 rings, and R 3 is a group of the formula 1 where x and z are each independently an integer from 1 to 4 and y is an integer from 1 to 2, and R 4 , R 5 , and R 6 are each independently H—, halo, HO—, H 2 N—, CN—, O 2 N—, HS—, O 3 S—, O 3 SO—, —COOH, —CONH 2 , R, RO—, RNH—, R a R b N—, RO 3 S—, RO 3 SO—, —COOR, —CONHR, or —CONR a R b , where R, R a and R b are each independently lower alkyl, cycloalkyl, lower alkenyl, lower alkynyl, or phenyl, or two R 4 , R 5 , or R 6 together form a fused aryl ring.

  含有损伤或错误的双链多核苷酸用受阻插层化合物进行检测，这种化合物只有在出现这种损伤或错误时才能够插层。在出现多核苷酸错误或损伤的情况下，可使用能在光的作用下催化多核苷酸裂解的化合物进行处理。合适的化合物包括式中的化合物： Rh(R 1 )(R 2 )(R 3 ) 3&plus； 其中 R 1 和 R 2 各自独立地为 1 至 5 个环的芳基、杂芳基、取代的芳基或取代的杂芳基，且 R 3 是式中的基团 1 其中 x 和 z 各自独立地为 1 至 4 的整数，y 为 1 至 2 的整数，且 R 4 , R 5 和 R 6 各自独立地为 H-、卤素、HO-、H 2 N-, CN-, O 2 N-、HS-、O 3 S-、O 3 SO-, -COOH, -CONH 2 ，r，ro-，rnh-，r a R b N-，RO 3 S-，RO 3 SO-、-COOR、-CONHR 或 -CONR a R b ，其中 R、R a 和 R b 各自独立地为低级烷基、环烷基、低级烯基、低级炔基或苯基，或两个 R 4 , R 5 或 R 6 共同形成一个融合芳基环。
• Gmelin Handbuch der Anorganischen Chemie, Gmelin Handbook: Ni: MVol.C2, 3, page 542 - 549
  作者：

  DOI：——

  日期：——