4-(2-Propyl)-8-nonen-2-one | 156418-94-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(2-Propyl)-8-nonen-2-one
• 英文别名: 4-Propan-2-ylnon-8-en-2-one
• CAS: 156418-94-9
• 化学式: C₁₂H₂₂O
• 分子量: 182.306
• InChiKey: VJHFNDQEAQIBFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-(2-Propyl)-8-nonen-2-one 在 六甲基磷酰三胺 、 samarium diiodide 、 叔丁醇 作用下， 以 四氢呋喃 为溶剂， 以63%的产率得到(1R*,3R*)-1-Methyl-3-(2-propyl)cyclooctan-1-ol
  参考文献：
  名称：

  Synthesis of Substituted Cyclooctanols by a Samarium(II) Iodide Promoted 8-Endo Radical Cyclization Process

  摘要：

  Samarium(II) iodide (SmI2) has been employed to promote an efficient 8-endo radical cyclization reaction of a variety of substituted olefinic ketones. Various substituted monocyclic, fused bicyclic, and bridged bicyclic cyclooctanols have been synthesized in fair to excellent yield via this protocol. In addition to delineating the synthetic potential of this reaction, experiments have been conducted to determine the source of reduced, noncyclized byproducts present in this and related SmI2-mediated reactions performed under protic conditions.

  DOI：

  10.1021/jo00090a041
• 作为产物：
  描述：

  magnesium,pent-1-ene,bromide 在 盐酸 、 四甲基乙二胺 作用下， 反应 0.83h， 生成 4-(2-Propyl)-8-nonen-2-one
  参考文献：
  名称：

  Synthesis of Substituted Cyclooctanols by a Samarium(II) Iodide Promoted 8-Endo Radical Cyclization Process

  摘要：

  Samarium(II) iodide (SmI2) has been employed to promote an efficient 8-endo radical cyclization reaction of a variety of substituted olefinic ketones. Various substituted monocyclic, fused bicyclic, and bridged bicyclic cyclooctanols have been synthesized in fair to excellent yield via this protocol. In addition to delineating the synthetic potential of this reaction, experiments have been conducted to determine the source of reduced, noncyclized byproducts present in this and related SmI2-mediated reactions performed under protic conditions.

  DOI：

  10.1021/jo00090a041

文献信息

• Molander Gary A., McKie Jeffrey A., J. Org. Chem, 59 (1994) N 11, S 3186-3192
  作者：Molander Gary A., McKie Jeffrey A.

  DOI：——

  日期：——
• Synthesis of Substituted Cyclooctanols by a Samarium(II) Iodide Promoted 8-Endo Radical Cyclization Process
  作者：Gary A. Molander、Jeffrey A. McKie

  DOI：10.1021/jo00090a041

  日期：1994.6

  Samarium(II) iodide (SmI2) has been employed to promote an efficient 8-endo radical cyclization reaction of a variety of substituted olefinic ketones. Various substituted monocyclic, fused bicyclic, and bridged bicyclic cyclooctanols have been synthesized in fair to excellent yield via this protocol. In addition to delineating the synthetic potential of this reaction, experiments have been conducted to determine the source of reduced, noncyclized byproducts present in this and related SmI2-mediated reactions performed under protic conditions.