2-(2-methylthioethyl)-9-[2-deoxy-3’,5’-O-bis-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]adenine | 1414930-05-4

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 2-(2-methylthioethyl)-9-[2-deoxy-3’,5’-O-bis-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]adenine
• 英文别名: 9-[(2R,4S,5R)-4-[tert-butyl(dimethyl)silyl]oxy-5-[[tert-butyl(dimethyl)silyl]oxymethyl]oxolan-2-yl]-2-(2-methylsulfanylethyl)purin-6-amine
• CAS: 1414930-05-4
• 化学式: C₂₅H₄₇N₅O₃SSi₂
• 分子量: 553.917
• InChiKey: MXFWMNMGVJWZGK-NLWGTHIKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.01
• 重原子数：
  36
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  123
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  2-(2-methylthioethyl)-9-[2-deoxy-3’,5’-O-bis-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]adenine 在 吡啶 、 四丁基氟化铵 、 1-羟基苯并三唑 作用下， 以 四氢呋喃 、 吡啶 为溶剂， 反应 27.5h， 生成 2-(2-methylthioethyl)-6-phenoxyacetylamino-9-[2’-deoxy-5’-O-(4,4’-dimethoxytrityl)-β-D-ribofuranosyl]purine
  参考文献：
  名称：

  Synthesis of 6-amino-2-vinylpurine derivatives for cross-linking and evaluation of the reactivity

  摘要：

  Oligodeoxynucleotides (ODNs) have been widely used for inhibiting the gene expression in antisense or antigene methods, and the interstrand cross-linking (ICL) forming ODNs have been expected to ensure the inhibition by these methods. Previously, we reported a highly efficient and selective ICL reaction toward cytosine using the 2-amino-6-vinylpurine derivative under acidic conditions. In this Letter, we report the synthesis of ODN containing 6-amino-2-vinylpurine derivatives and evaluation of the cross-linking reactivity. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.08.122
• 作为产物：
  描述：

  2-iodo-9-<2-deoxy-3,5-O-bis-(tert-butyldimethylsilyl)-β-D-ribofuranosyl>adenine 在 双(乙腈)氯化钯(II) 作用下， 以 水 、 乙腈 为溶剂， 反应 77.0h， 生成 2-(2-methylthioethyl)-9-[2-deoxy-3’,5’-O-bis-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]adenine
  参考文献：
  名称：

  Synthesis of 6-amino-2-vinylpurine derivatives for cross-linking and evaluation of the reactivity

  摘要：

  Oligodeoxynucleotides (ODNs) have been widely used for inhibiting the gene expression in antisense or antigene methods, and the interstrand cross-linking (ICL) forming ODNs have been expected to ensure the inhibition by these methods. Previously, we reported a highly efficient and selective ICL reaction toward cytosine using the 2-amino-6-vinylpurine derivative under acidic conditions. In this Letter, we report the synthesis of ODN containing 6-amino-2-vinylpurine derivatives and evaluation of the cross-linking reactivity. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.08.122

文献信息

• Synthesis of 6-amino-2-vinylpurine derivatives for cross-linking and evaluation of the reactivity
  作者：Shuhei Kusano、Tomoya Sakuraba、Shinya Hagihara、Fumi Nagatsugi

  DOI：10.1016/j.bmcl.2012.08.122

  日期：2012.11

  Oligodeoxynucleotides (ODNs) have been widely used for inhibiting the gene expression in antisense or antigene methods, and the interstrand cross-linking (ICL) forming ODNs have been expected to ensure the inhibition by these methods. Previously, we reported a highly efficient and selective ICL reaction toward cytosine using the 2-amino-6-vinylpurine derivative under acidic conditions. In this Letter, we report the synthesis of ODN containing 6-amino-2-vinylpurine derivatives and evaluation of the cross-linking reactivity. (C) 2012 Elsevier Ltd. All rights reserved.