2,2-双(羟甲基)乙酸丁酯 | 58878-16-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 2,2-双(羟甲基)乙酸丁酯
• 英文名称: trimethylolpropane monoethanoate
• 英文别名: 2,2-Bis(hydroxymethyl)butyl acetate
• CAS: 58878-16-3
• 化学式: C₈H₁₆O₄
• 分子量: 176.213
• InChiKey: OZHDAAJPKOJVCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  三羟甲基丙烷 、 溶剂黄146 在 磷酸 作用下， 以 苯 为溶剂， 生成 2,2-双(羟甲基)乙酸丁酯 、 trimethylolpropane diethanoate 、 2-乙基-2-(乙酰氧基甲基)-1,3-丙烷二醇二乙酸酯
  参考文献：
  名称：

  三羟甲基丙烷和С2 –С 5酸的酯在DB-1固定相上的气相保留和吸附焓的特征

  摘要：

  在220–280°C的温度范围内，对21种三羟甲基丙烷和一元酸的单，二和三取代酯确定了保留特性及其温度依赖性以及DB-1非极性相上吸附的热力学特性。具有2至6个碳原子的各种结构。

  DOI：

  10.1134/s0036024417020194

文献信息

• DINUCLEOTIDE COMPOUNDS FOR HCV INFECTION
  申请人：IDENIX PHARMACEUTICALS, INC.

  公开号：US20140112886A1

  公开（公告）日：2014-04-24

  Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds comprise two 2′-methyl nucleotides linked according to Formula I: N 1 -L-N 2 (I) or a pharmaceutically acceptable salt, ester, solvate, stereoisomer, isomeric form, tautomeric form or polymorphic form thereof; wherein N 1 , L and N 2 are as described herein.

  本文提供了用于治疗黄病毒科感染，包括HCV感染的化合物、组合物和方法。在某些实施方式中，披露了核苷类衍生物的化合物和组合物，可以单独或与其他抗病毒药物联合给药。在某些实施方式中，所述化合物包括根据以下式I连接的两个2'-甲基核苷酸：N1-L-N2(I)或其药学上可接受的盐、酯、溶剂合物、立体异构体、同分异构体、互变异构体或其多形形式；其中N1、L和N2如本文所述。
• Acryloyloxy and methacryloyloxy group-containing condensation polymers
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0309249A2

  公开（公告）日：1989-03-29

  Organic solvent soluble, acryloyloxy and methacryloyloxy group-containing, condensation polymers are crosslinkable and useful for providing chemical, solvent, and abrasion resistant articles. The condensation polymers are polyesters or polyurethanes having an acryloyloxy or methacryloyloxyalkanediol component that is uncontaminated by hydroxyl group-containing compounds having one, three, or more hydroxyl groups or compounds in which the acryloyloxy or methacryloyloxy group is attached to a secondary carbon atom.

  含丙烯酰氧基和甲基丙烯酰氧基基团的有机溶剂可溶缩合聚合物具有可交联性，可用于制造耐化学、耐溶剂和耐磨损的物品。缩聚聚合物是具有丙烯酰氧基或甲基丙烯酰氧基烷二醇组分的聚酯或聚氨酯，该组分未被具有一个、三个或更多羟基的含羟基化合物或丙烯酰氧基或甲基丙烯酰氧基与仲碳原子相连的化合物污染。
• Synthesis and GC-MS study of fluorinated esters derived from thrimethylolpropane
  作者：M. G. Pervova、V. E. Kirichenko、T. I. Gorbunova、A. Ya. Zapevalov、V. I. Saloutin

  DOI：10.1134/s1070363208090107

  日期：2008.9

  Zol-gel process was used to synthesize equilibrium mixtures of mono-, di-, and trimester derived from trimethylolpropane and perfluorocarboxylic acids. The elution order of the components of the mixtures from a weakly polar HP-5 column was established. The mass spectra of the synthesized compounds were studied. The GC-MS parameters of the products were compared with the respective parameters of their nonfluorinated analogs. The characteristics of the fluorinated esters have features determined by the esterification degree and the nature of the perfluoroalkyl groups, due to which these compounds can be identified in mixtures.
• VOC FREE PRODUCT
  申请人：Bwe I Malmö Ab

  公开号：EP2699633A1

  公开（公告）日：2014-02-26
• PHOTOINITATORS
  申请人：Coloplast A/S

  公开号：EP3545009B1

  公开（公告）日：2021-07-21