3-benzyloxycarbonylamino-1-propyl O-(6-tert-butyldiphenylsilyl-β-D-galactopyranosyl)-(1-4)-2-acetamido-6-O-tert-butyldiphenylsilyl-2-deoxy-β-D-glucopyranoside | 347391-81-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-benzyloxycarbonylamino-1-propyl O-(6-tert-butyldiphenylsilyl-β-D-galactopyranosyl)-(1-4)-2-acetamido-6-O-tert-butyldiphenylsilyl-2-deoxy-β-D-glucopyranoside
• 英文别名: benzyl N-[3-[(2R,3R,4R,5S,6R)-3-acetamido-6-[[tert-butyl(diphenyl)silyl]oxymethyl]-5-[(2S,3R,4S,5R,6R)-6-[[tert-butyl(diphenyl)silyl]oxymethyl]-3,4,5-trihydroxyoxan-2-yl]oxy-4-hydroxyoxan-2-yl]oxypropyl]carbamate
• CAS: 347391-81-5
• 化学式: C₅₇H₇₄N₂O₁₃Si₂
• 分子量: 1051.39
• InChiKey: DCGBOQTXFQUUQF-RSPFRYNESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.26
• 重原子数：
  74
• 可旋转键数：
  23
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  204
• 氢给体数：
  6
• 氢受体数：
  13

反应信息

• 作为反应物：
  描述：

  3-benzyloxycarbonylamino-1-propyl O-(6-tert-butyldiphenylsilyl-β-D-galactopyranosyl)-(1-4)-2-acetamido-6-O-tert-butyldiphenylsilyl-2-deoxy-β-D-glucopyranoside 在 pyridinium triflate 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 2.25h， 生成 3-benzyloxycarbonylamino-1-propyl O-(2,4-di-O-acetyl-6-O-tert-butyldiphenylsilyl-β-D-galactopyranosyl)-(1-4)-3-O-acetyl-2-acetamido-6-O-tert-butyldiphenylsilyl-2-deoxy-β-D-glucopyranoside
  参考文献：
  名称：

  Practical syntheses of B disaccharide and linear B type 2 trisaccharide—non-primate epitope markers recognized by human anti-α-Gal antibodies causing hyperacute rejection of xenotransplants

  摘要：

  Synthetic protocols are presented for the elaboration of Gal alpha1 --> 3GalOR and Gal alpha1 --> 3Gal beta1 --> 4GlcNAcOR di- and trisaccharides that use a common Gal donor/acceptor unit, and are potentially adaptable to scale-up. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00196-x
• 作为产物：
  描述：

  在 一水合肼 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 1.0h， 生成 3-benzyloxycarbonylamino-1-propyl O-(6-tert-butyldiphenylsilyl-β-D-galactopyranosyl)-(1-4)-2-acetamido-6-O-tert-butyldiphenylsilyl-2-deoxy-β-D-glucopyranoside
  参考文献：
  名称：

  Practical syntheses of B disaccharide and linear B type 2 trisaccharide—non-primate epitope markers recognized by human anti-α-Gal antibodies causing hyperacute rejection of xenotransplants

  摘要：

  Synthetic protocols are presented for the elaboration of Gal alpha1 --> 3GalOR and Gal alpha1 --> 3Gal beta1 --> 4GlcNAcOR di- and trisaccharides that use a common Gal donor/acceptor unit, and are potentially adaptable to scale-up. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(01)00196-x