3-溴-1-丙醇-D6 | 284474-43-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3-溴-1-丙醇-D6
• 英文名称: 3-bromopropanol-d₆
• 英文别名: 3-bromo(²H₆)propane-1-ol；3-Bromo-1-propan-d6-ol；3-bromo-1,1,2,2,3,3-hexadeuteriopropan-1-ol
• CAS: 284474-43-7
• 化学式: C₃H₇BrO
• 分子量: 144.944
• InChiKey: RQFUZUMFPRMVDX-NMFSSPJFSA-N

物化性质

• 沸点：
  62 °C5 mm Hg(lit.)
• 密度：
  1.602 g/mL at 25 °C

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  5
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-溴-1-丙醇-D6 在 sodium sulfite 作用下， 以 水 为溶剂， 生成 3-hydroxy(²H₆)propane-1-sulfonic acid
  参考文献：
  名称：

  WO2024084360A1

  摘要：

  公开号：
• 作为产物：
  描述：

  1,3-丙二醇-D6 在 氢溴酸 作用下， 以 水 、 苯 为溶剂， 反应 28.0h， 以82%的产率得到3-溴-1-丙醇-D6
  参考文献：
  名称：

  Gold-Catalyzed Diastereoselective Cycloisomerization of Alkylidene-Cyclopropane-Bearing 1,6-Diynes

  摘要：

  AbstractAn unprecedented gold‐catalyzed diastereoselective cycloisomerization of 1,6‐diynes bearing an alkylidene cyclopropane moiety has been developed. This methodology enables rapid access to a variety of 1,2‐trimethylenenorbornanes, which are important building blocks in the preparations of abiotic and sesquiterpene core structures.

  DOI：

  10.1002/anie.201405147

文献信息

• [EN] DEUTERATED PITOLISANT<br/>[FR] PITOLISANT DEUTÉRÉ
  申请人：CONCERT PHARMACEUTICALS INC

  公开号：WO2020092604A1

  公开（公告）日：2020-05-07

  This invention also provides compound of Formula (I) including pharmaceutical compositions comprising a compound of Formula (I) and a pharmaceutically acceptable carrier. This invention also provides the use of such compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering pitolisant. Some exemplary embodiments include a method of treating a disease or condition selected from narcolepsy, daytime sleepiness (particularly in subjects suffering from Parkinson's disease or obstructive sleep apnea syndrome), and cognitive defects in psychiatric conditions, the method comprising the step of administering to a subject in need thereof a pharmaceutically acceptable composition of the present invention.

  本发明还提供了一种包括化合物Formula (I)的复合物，其中包括一种Formula (I)化合物和药学上可接受的载体的药物组合物。本发明还提供了利用这些化合物和组合物在治疗疾病和病况的方法中的应用，这些疾病和病况通过给予pitolisant进行有益治疗。一些示例实施方式包括治疗疾病或病况的方法，所述疾病或病况选自嗜睡症、白天嗜睡（特别是患有帕金森病或阻塞性睡眠呼吸暂停综合征的患者）和精神病症中的认知缺陷，所述方法包括向需要的受试者给予本发明的药学上可接受的组合物。
• Derivatives of gefitinib
  申请人：Tung Roger

  公开号：US09133137B2

  公开（公告）日：2015-09-15

  This invention relates to novel quinazoline derivatives, their derivatives, pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by inhibiting cell surface tyrosine receptor kinases.

  本发明涉及新型喹唑啉衍生物及其衍生物，以及其药学上可接受的盐。本发明还提供了包含本发明化合物的组合物，并且利用这些组合物来治疗通过抑制细胞表面酪氨酸受体激酶有益治疗的疾病和症状的方法。
• Isotope-coded chemical reporter and acid-cleavable affinity reagents for monitoring protein sulfenic acids
  作者：Thu H. Truong、Francisco J. Garcia、Young Ho Seo、Kate S. Carroll

  DOI：10.1016/j.bmcl.2011.04.115

  日期：2011.9

  We have developed an approach that allows relative quantification of protein sulfenic acids using a pair of light and heavy isotope labled probes, DAz-2 and d(6)-DAz-2. In conjunction with a new complementary acid-cleavable linker, Yn-ACL, we demonstrate that tagged peptides are successfully labeled, enriched, and fully characterized by LC-MS/MS analysis. Overall, this method can be applied to map sites of cysteine oxidation and compare protein sulfenylation in normal and disease states. Published by Elsevier Ltd.
• Gold-Catalyzed Diastereoselective Cycloisomerization of Alkylidene-Cyclopropane-Bearing 1,6-Diynes
  作者：Hongchao Zheng、Laura L. Adduci、Ryan J. Felix、Michel R. Gagné

  DOI：10.1002/anie.201405147

  日期：2014.7.21

  AbstractAn unprecedented gold‐catalyzed diastereoselective cycloisomerization of 1,6‐diynes bearing an alkylidene cyclopropane moiety has been developed. This methodology enables rapid access to a variety of 1,2‐trimethylenenorbornanes, which are important building blocks in the preparations of abiotic and sesquiterpene core structures.
• WO2024084360A1
  申请人：——

  公开号：——

  公开（公告）日：——