2,4-bis-allyloxy-pyrimidine | 1489-12-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,4-bis-allyloxy-pyrimidine
• 英文别名: 2,4-Bis(prop-2-en-1-yloxy)pyrimidine；2,4-bis(prop-2-enoxy)pyrimidine
• CAS: 1489-12-9
• 化学式: C₁₀H₁₂N₂O₂
• 分子量: 192.217
• InChiKey: LTXXFFSWFQKSJC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  44.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-氯-2-甲磺酰基嘧啶 、 烯丙醇 在 potassium tert-butylate 作用下， 生成 4-chloro-2-propenyloxypyrimidine 、 2,4-bis-allyloxy-pyrimidine
  参考文献：
  名称：

  Falck-Pedersen, Mette Lene; Benneche, Tore; Undheim, Kjell, Acta Chemica Scandinavica, 1993, vol. 47, # 1, p. 72 - 79

  摘要：

  DOI：

文献信息

• Process for preparation of polyhydric alcohols
  申请人：——

  公开号：US20020157939A1

  公开（公告）日：2002-10-31

  A process for preparing a polyhydric alcohol according to the invention comprises subjecting a polyhydric alcohol compound having protected hydroxy group(s) to microwave irradiation in the presence of basic compound(s) or acid(s) having an acid dissociation exponent (pKa) of −8 to 3 at 25° C. to remove the protecting groups of the hydroxy group of the polyhydric alcohol compound. The invention can provide an industrially advantageous process for preparing polyhydric alcohols by readily removing protecting group(s) from protected hydroxy group(s) of polyhydric alcohol compounds.

  根据该发明，制备多羟基醇的方法包括将具有受保护羟基的多羟基醇化合物置于存在具有25°C下酸解离指数（pKa）为-8至3的碱性化合物或酸性化合物的微波辐射中，以去除多羟基醇化合物的羟基的保护基。该发明可以通过轻松去除多羟基醇化合物中受保护羟基的保护基，提供一个工业上有利的制备多羟基醇的方法。
• Stereocontrolled synthesis of β-2′-deoxypyrimidine nucleosides via intramolecular glycosylations
  作者：Xiaoyang Xia、Jianying Wang、Michael W. Hager、Nicholas Sisti、Dennis C. Liotta

  DOI：10.1016/s0040-4039(96)02520-8

  日期：1997.2

  moiety was tethered at the 3′-β-position of D-threo-furanosides. By carefully controlling the reaction conditions, pyrimidine bases can be delivered to the anomeric center to give of β-pyrimidine nucleosides in good yield and with complete stereocontrol.

  嘧啶部分被束缚在D-苏-呋喃糖苷的3'-β-位置。通过仔细控制反应条件，可以将嘧啶碱基递送至异头异构中心，以高收率和完全的立体控制得到β-嘧啶核苷。
• PROCESS FOR THE PREPARATION OF POLYHYDRIC ALCOHOLS
  申请人：National Institute of Advanced Industrial Science and Technology

  公开号：EP1298115A1

  公开（公告）日：2003-04-02

  A process for preparing a polyhydric alcohol according to the invention comprises subjecting a polyhydric alcohol compound having protected hydroxy group(s) to microwave irradiation in the presence of basic compound(s) or acid(s) having an acid dissociation exponent (pKa) of -8 to 3 at 25°C to remove the protecting groups of the hydroxy group of the polyhydric alcohol compound. The invention can provide an industrially advantageous process for preparing polyhydric alcohols by readily removing protecting group(s) from protected hydroxy group(s) of polyhydric alcohol compounds.

  根据本发明制备多元醇的工艺包括：在碱性化合物或酸解离指数（pKa）为-8 至 3 的酸存在下，在 25°C 的温度下，对具有受保护羟基的多元醇化合物进行微波辐照，以去除多元醇化合物羟基的保护基团。本发明可提供一种具有工业优势的制备多羟基醇的工艺，该工艺可轻松去除多羟基醇化合物受保护羟基上的保护基团。
• US6656328B2
  申请人：——

  公开号：US6656328B2

  公开（公告）日：2003-12-02