(2S,5R,8S,11S,14S,16Z,19S)-8-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-2-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-5-(1H-indol-3-ylmethyl)-3,6,9,12,20-pentaoxo-11-[(4-phenylmethoxyphenyl)methyl]-1,4,7,10,13-pentazacycloicos-16-ene-14-carboxamide | 1241047-37-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S,5R,8S,11S,14S,16Z,19S)-8-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-2-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-5-(1H-indol-3-ylmethyl)-3,6,9,12,20-pentaoxo-11-[(4-phenylmethoxyphenyl)methyl]-1,4,7,10,13-pentazacycloicos-16-ene-14-carboxamide
• CAS: 1241047-37-9
• 化学式: C₆₃H₇₆N₁₀O₁₀
• 分子量: 1133.36
• InChiKey: IEHNXMNAIZPSPF-ZTEDRTMSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  83
• 可旋转键数：
  21
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  321
• 氢给体数：
  12
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  (2S,5R,8S,11S,14S,16Z,19S)-8-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-2-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-5-(1H-indol-3-ylmethyl)-3,6,9,12,20-pentaoxo-11-[(4-phenylmethoxyphenyl)methyl]-1,4,7,10,13-pentazacycloicos-16-ene-14-carboxamide 在 Wilkinson's catalyst 氢气 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 30.0 ℃ 、413.69 kPa 条件下， 反应 30.0h， 以13%的产率得到(2S,5R,8S,11S,14S,19S)-8-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-2-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-5-(1H-indol-3-ylmethyl)-3,6,9,12,20-pentaoxo-11-[(4-phenylmethoxyphenyl)methyl]-1,4,7,10,13-pentazacycloicosane-14-carboxamide
  参考文献：
  名称：

  Novel sst₅-Selective Somatostatin Dicarba-Analogues: Synthesis and Conformation−Affinity Relationships

  摘要：

  We describe synthesis, conformational studies, and binding to the five somatostatin receptors (SSt(1-5)) of a few analogues of the cyclic octapeptide octreotide (1), where the disulfide bridge was replaced by a dicarba group. These analogues were prepared by on-resin RCM of linear hepta-peptides containing two allylglycine residues; first- and second-generation Grubbs catalyst efficiencies were compared. The C=C bridge was hydrogenated via two different methods. Binding experiments showed that two analogues had good affinity and high selectivity for the SSt(5) receptor. Three-dimensional structures of the active analogues were determined by H-1 NMR spectroscopy. Conformation-affinity relationships confirmed the importance Of D-Phe(2) orientation for sst(2) affinity. Moreover, helical propensities well correlates with the peptide sst(5) affinity. The presence of the bulky aromatic side chain of Tyr(Bzl)(10) favored the formation of a 3(10)-helix and enhanced the sst(5) selectivity suppressing the sst(2) affinity. Finally, a new pharmacophore model for the sst(5) was developed.

  DOI：

  10.1021/jm070886i
• 作为产物：
  描述：

  Fmoc-L-苯丙氨酸 、 N-alpha-芴甲氧羰基-N-epsilon-叔丁氧羰基-L-赖氨酸 、 Fmoc-O-苄基-L-酪氨酸 、 N-alpha-芴甲氧羰基-N-in-叔丁氧羰基-D-色氨酸 、 alkaline earth salt of/the/ methylsulfuric acid 、 alkaline earth salt of/the/ methylsulfuric acid 以20%的产率得到(2S,5R,8S,11S,14S,16Z,19S)-8-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-2-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-5-(1H-indol-3-ylmethyl)-3,6,9,12,20-pentaoxo-11-[(4-phenylmethoxyphenyl)methyl]-1,4,7,10,13-pentazacycloicos-16-ene-14-carboxamide
  参考文献：
  名称：

  Novel sst₅-Selective Somatostatin Dicarba-Analogues: Synthesis and Conformation−Affinity Relationships

  摘要：

  We describe synthesis, conformational studies, and binding to the five somatostatin receptors (SSt(1-5)) of a few analogues of the cyclic octapeptide octreotide (1), where the disulfide bridge was replaced by a dicarba group. These analogues were prepared by on-resin RCM of linear hepta-peptides containing two allylglycine residues; first- and second-generation Grubbs catalyst efficiencies were compared. The C=C bridge was hydrogenated via two different methods. Binding experiments showed that two analogues had good affinity and high selectivity for the SSt(5) receptor. Three-dimensional structures of the active analogues were determined by H-1 NMR spectroscopy. Conformation-affinity relationships confirmed the importance Of D-Phe(2) orientation for sst(2) affinity. Moreover, helical propensities well correlates with the peptide sst(5) affinity. The presence of the bulky aromatic side chain of Tyr(Bzl)(10) favored the formation of a 3(10)-helix and enhanced the sst(5) selectivity suppressing the sst(2) affinity. Finally, a new pharmacophore model for the sst(5) was developed.

  DOI：

  10.1021/jm070886i

文献信息

• Novel Octreotide Dicarba-analogues with High Affinity and Different Selectivity for Somatostatin Receptors
  作者：Alessandra Di Cianni、Alfonso Carotenuto、Diego Brancaccio、Ettore Novellino、Jean Claude Reubi、Karin Beetschen、Anna Maria Papini、Mauro Ginanneschi

  DOI：10.1021/jm1005868

  日期：2010.8.26

  A limited set of novel octreotide dicarba-analogues with non-native aromatic side chains in positions 7 and/or 10 were synthesized. Their affinity toward the ssts(1-5) was determined. Derivative 4 exhibited a pan-somatostatin activity, except sst(4), and derivative 8 exhibited high affinity and selectivity toward sst(5). Actually, compound 8 has similar sst(5) affinity (IC(50) 4.9 nM) to SRIF-28 and octreotide. Structure activity relationships suggest that the Z geometry of the double-bond bridge is that preferred by the receptors. The NMR study on the conformations of these compounds in SDS(-d25) micelles solution shows that all these analogues have the pharmacophore beta-turn spanning Xaa(7)-D-Trp(8)-Lys(9)-Yaa(10) residues. Notably, the correlation between conformation families and affinity data strongly indicates that the sst(5) selectivity is favored by a helical conformation involving the C-terminus triad, while a pan-SRIF mimic activity is based mainly on a conformational equilibrium between extended and folded conformational states.
• Novel sst₅-Selective Somatostatin Dicarba-Analogues: Synthesis and Conformation−Affinity Relationships
  作者：Debora D’Addona、Alfonso Carotenuto、Ettore Novellino、Véronique Piccand、Jean Claude Reubi、Alessandra Di Cianni、Francesca Gori、Anna Maria Papini、Mauro Ginanneschi

  DOI：10.1021/jm070886i

  日期：2008.2.1

  We describe synthesis, conformational studies, and binding to the five somatostatin receptors (SSt(1-5)) of a few analogues of the cyclic octapeptide octreotide (1), where the disulfide bridge was replaced by a dicarba group. These analogues were prepared by on-resin RCM of linear hepta-peptides containing two allylglycine residues; first- and second-generation Grubbs catalyst efficiencies were compared. The C=C bridge was hydrogenated via two different methods. Binding experiments showed that two analogues had good affinity and high selectivity for the SSt(5) receptor. Three-dimensional structures of the active analogues were determined by H-1 NMR spectroscopy. Conformation-affinity relationships confirmed the importance Of D-Phe(2) orientation for sst(2) affinity. Moreover, helical propensities well correlates with the peptide sst(5) affinity. The presence of the bulky aromatic side chain of Tyr(Bzl)(10) favored the formation of a 3(10)-helix and enhanced the sst(5) selectivity suppressing the sst(2) affinity. Finally, a new pharmacophore model for the sst(5) was developed.