2-(4-methoxybenzyl)-5-(4-methoxyphenyl)pyrazole 1-oxide | 438193-53-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-methoxybenzyl)-5-(4-methoxyphenyl)pyrazole 1-oxide
• 英文别名: 3-(4-Methoxyphenyl)-1-[(4-methoxyphenyl)methyl]-2-oxidopyrazol-2-ium
• CAS: 438193-53-4
• 化学式: C₁₈H₁₈N₂O₃
• 分子量: 310.353
• InChiKey: OMTUFJTWNBJMKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  48.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(4-methoxybenzyl)-5-(4-methoxyphenyl)pyrazole 1-oxide 在 N-溴代丁二酰亚胺(NBS) 、 异丙基氯化镁 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 15.0h， 生成 4-bromo-2-(4-methoxybenzyl)-5-(4-methoxyphenyl)-3-(4-methylphenyl)pyrazole-1-oxide
  参考文献：
  名称：

  Sequential Functionalization of Pyrazole 1-Oxides via Regioselective Metalation:  Synthesis of 3,4,5-Trisubstituted 1-Hydroxypyrazoles

  摘要：

  A range of 3,5-diarylated and 3,4,5-triarylated 2-(4-methoxybenzyl)pyrazole I-oxides have been prepared by regioselective deprotonation at C-5 or bromine-magnesium exchange at C-3 or C-4 followed by transmetalation with ZnCl2 and palladium(0)-catalyzed cross-coupling. Furthermore, the metalated pyrazole 1-oxides could be trapped with electrophiles. The sequential metalation/functionalization of the pyrazole I-oxides may follow the order C-5, C-3, C-4, or alternatively the order C-3, C-5, C-4. The 4-methoxybenzyl group of the functionalized 2-(4-methoxybenzyl)pyrazole 1-oxides could be removed by treatment with TFA and i-Pr3SiH in CH2Cl2, providing the corresponding functionalized 1-hydroxypyrazoles.

  DOI：

  10.1021/jo015997i
• 作为产物：
  描述：

  4-碘苯甲醚 、 1H-吡唑,1-[(4-甲氧苯基)甲基]-,2-氧化 在 四(三苯基膦)钯 异丙基氯化镁 、 zinc(II) chloride 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以95%的产率得到2-(4-methoxybenzyl)-5-(4-methoxyphenyl)pyrazole 1-oxide
  参考文献：
  名称：

  Sequential Functionalization of Pyrazole 1-Oxides via Regioselective Metalation:  Synthesis of 3,4,5-Trisubstituted 1-Hydroxypyrazoles

  摘要：

  A range of 3,5-diarylated and 3,4,5-triarylated 2-(4-methoxybenzyl)pyrazole I-oxides have been prepared by regioselective deprotonation at C-5 or bromine-magnesium exchange at C-3 or C-4 followed by transmetalation with ZnCl2 and palladium(0)-catalyzed cross-coupling. Furthermore, the metalated pyrazole 1-oxides could be trapped with electrophiles. The sequential metalation/functionalization of the pyrazole I-oxides may follow the order C-5, C-3, C-4, or alternatively the order C-3, C-5, C-4. The 4-methoxybenzyl group of the functionalized 2-(4-methoxybenzyl)pyrazole 1-oxides could be removed by treatment with TFA and i-Pr3SiH in CH2Cl2, providing the corresponding functionalized 1-hydroxypyrazoles.

  DOI：

  10.1021/jo015997i

文献信息

• Sequential Functionalization of Pyrazole 1-Oxides via Regioselective Metalation:  Synthesis of 3,4,5-Trisubstituted 1-Hydroxypyrazoles
  作者：Anna Sif Paulson、Jørgen Eskildsen、Per Vedsø、Mikael Begtrup

  DOI：10.1021/jo015997i

  日期：2002.5.1

  A range of 3,5-diarylated and 3,4,5-triarylated 2-(4-methoxybenzyl)pyrazole I-oxides have been prepared by regioselective deprotonation at C-5 or bromine-magnesium exchange at C-3 or C-4 followed by transmetalation with ZnCl2 and palladium(0)-catalyzed cross-coupling. Furthermore, the metalated pyrazole 1-oxides could be trapped with electrophiles. The sequential metalation/functionalization of the pyrazole I-oxides may follow the order C-5, C-3, C-4, or alternatively the order C-3, C-5, C-4. The 4-methoxybenzyl group of the functionalized 2-(4-methoxybenzyl)pyrazole 1-oxides could be removed by treatment with TFA and i-Pr3SiH in CH2Cl2, providing the corresponding functionalized 1-hydroxypyrazoles.