3-乙炔基-6-甲氧基哒嗪 | 1019331-16-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 3-乙炔基-6-甲氧基哒嗪
• 英文名称: 3-ethynyl-6-methoxypyridazine
• 英文别名: 3-Ethynyl-6-methoxypyridazine
• CAS: 1019331-16-8
• 化学式: C₇H₆N₂O
• 分子量: 134.137
• InChiKey: RALVCNMFOJCDLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-乙炔基-6-甲氧基哒嗪 在 硫酸 、 水 、 mercury(II) sulfate 作用下， 反应 2.0h， 以50%的产率得到1-(6-methoxypyridazin-3-yl)ethanone
  参考文献：
  名称：

  First synthesis of novel 3,3′-bipyridazine derivatives as new potent antihepatocellular carcinoma agents

  摘要：

  Hepatocellular carcinoma is one of the most common kind of cancers in clinical, and its clinical treatment is quite difficult. The latest research suggests that pyridazinone with a novel molecular skeleton shows excellent activity against hepatocellular carcinoma in vitro and in vivo. Considering YHHU-759 as the leading compound for reasonable structure modification, a series of 3,3'-bipyridazine derivatives including 8 novel compounds in this study were designed, synthesized and screened for their ann-hepatoma activities against liver cancer cell lines SMMC-7721, BEL-7402 and QGY-7703 in vitro. The result shows that all of the 3,3'-bipyridazine derivatives have good anti-hepatoma activities. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.07.063
• 作为产物：
  描述：

  3-碘代-6-甲氧基哒嗪 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 四丁基氟化铵 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 2.5h， 生成 3-乙炔基-6-甲氧基哒嗪
  参考文献：
  名称：

  First synthesis of novel 3,3′-bipyridazine derivatives as new potent antihepatocellular carcinoma agents

  摘要：

  Hepatocellular carcinoma is one of the most common kind of cancers in clinical, and its clinical treatment is quite difficult. The latest research suggests that pyridazinone with a novel molecular skeleton shows excellent activity against hepatocellular carcinoma in vitro and in vivo. Considering YHHU-759 as the leading compound for reasonable structure modification, a series of 3,3'-bipyridazine derivatives including 8 novel compounds in this study were designed, synthesized and screened for their ann-hepatoma activities against liver cancer cell lines SMMC-7721, BEL-7402 and QGY-7703 in vitro. The result shows that all of the 3,3'-bipyridazine derivatives have good anti-hepatoma activities. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.07.063

文献信息

• Synthesis and optical properties of multibranched and C3 symmetrical oligomers with benzene or triphenylamine core and diazines as peripheral groups
  作者：Flavia-Adina Martin、Christine Baudequin、Catherine Fiol-Petit、Mircea Darabantu、Yvan Ramondenc、Nelly Plé

  DOI：10.1016/j.tet.2014.02.044

  日期：2014.4

  We report therein the synthesis and photophysical properties of a new series of two- and tribranched compounds built up from benzene or triphenylamine as central core and electron-withdrawing diazine rings as peripheral group. The arms allowing connection between these two parts are constituted by an ethynylene linker. All these compounds are fluorescent and are of particular interest with generally

  我们在其中报告了以苯或三苯胺为中心核和吸电子二嗪环为外围基团构建的一系列新的两支和三支化合物的合成和光物理性质。允许这两个部分之间连接的臂由亚乙炔基连接体构成。所有这些化合物都是荧光的，并且特别令人感兴趣，它们通常具有良好的量子产率和良好的斯托克斯位移。其中一些已经过测试，具有两光子吸收（TPA）特性，并且显示出有趣的性能。
• NITRIFICATION INHIBITORS
  申请人：Lincoln University

  公开号：US20220153655A1

  公开（公告）日：2022-05-19

  Nitrification inhibitors and uses of same to prevent nitrate leaching or nitrous oxide emissions as well as increase pasture or crop production. The nitrification inhibitors and formulations including same may be used for direct or indirect application to soil or pasture.

  硝化抑制剂及其用途，可防止硝酸盐淋失或氧化亚氮排放，并增加牧草或作物产量。硝化抑制剂及其配方可用于直接或间接施用于土壤或牧草。
• Oligomers Containing Ethynylpyridazine Moieties: Synthesis, Fluorescence and Liquid Crystalline Properties. Diazines 50
  作者：Nelly Plé、Sylvain Achelle、David Kreher、Fabrice Mathevet、Alain Turck

  DOI：10.3987/com-07-11220

  日期：——
• IMPROVEMENTS IN AND RELATING TO NITRIFICATION INHIBITORS
  申请人：Lincoln University

  公开号：EP3990417A1

  公开（公告）日：2022-05-04
• [EN] IMPROVEMENTS IN AND RELATING TO NITRIFICATION INHIBITORS<br/>[FR] AMÉLIORATIONS APPORTÉES ET SE RAPPORTANT À DES INHIBITEURS DE NITRIFICATION
  申请人：LINCOLN UNIV

  公开号：WO2021242122A1

  公开（公告）日：2021-12-02

  The present invention generally relates to nitrification inhibitors and uses of same to prevent nitrate leaching or nitrous oxide emissions as well as increase pasture or crop production. The present invention also relates to nitrification inhibitors and formulations including same for direct or indirect application to soil or pasture.