1,2,5,10-tetrahydro-1,10-dioxo-3-methylpyrido<4,3-b>quinoline | 86129-75-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1,2,5,10-tetrahydro-1,10-dioxo-3-methylpyrido<4,3-b>quinoline
• 英文别名: 3-Methyl-2,5-dihydrobenzo[b][1,6]naphthyridine-1,10-dione；3-methyl-2,5-dihydrobenzo[b][1,6]naphthyridine-1,10-dione
• CAS: 86129-75-1
• 化学式: C₁₃H₁₀N₂O₂
• 分子量: 226.235
• InChiKey: ITUSDPCIPIEZTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,2,5,10-tetrahydro-1,10-dioxo-3-methylpyrido<4,3-b>quinoline 在 三氯氧磷 作用下， 反应 5.0h， 生成 5,10-dihydro-10-oxo-1-<<3-(diethylamino)propyl>amino>-3-methylpyrido<4,3-b>quinoline
  参考文献：
  名称：

  Aza analogs of lucanthone: synthesis and antitumor and bactericidal properties

  摘要：

  Three types of aza analogues of lucanthone were synthesized for evaluation as antitumor drugs. None of the compounds was found to have significant cytotoxic effects either on Friend tumor cells or on L1210 leukemia cells. However, one of the target compounds, 5,10-dihydro-10-oxo-1-[[3-(diethylamino)propyl]amino]-3-methylpyrido [4,3-b]quinoline, was shown to have noticeable antibiotic properties.

  DOI：

  10.1021/jm00363a022
• 作为产物：
  描述：

  1,2-二氢-2-氧代-4-氯-6-甲基吡啶-3-羧酸乙酯 在 三乙胺 作用下， 以 乙醇 为溶剂， 反应 24.33h， 生成 1,2,5,10-tetrahydro-1,10-dioxo-3-methylpyrido<4,3-b>quinoline
  参考文献：
  名称：

  Aza analogs of lucanthone: synthesis and antitumor and bactericidal properties

  摘要：

  Three types of aza analogues of lucanthone were synthesized for evaluation as antitumor drugs. None of the compounds was found to have significant cytotoxic effects either on Friend tumor cells or on L1210 leukemia cells. However, one of the target compounds, 5,10-dihydro-10-oxo-1-[[3-(diethylamino)propyl]amino]-3-methylpyrido [4,3-b]quinoline, was shown to have noticeable antibiotic properties.

  DOI：

  10.1021/jm00363a022

文献信息

• Aza analogs of lucanthone: synthesis and antitumor and bactericidal properties
  作者：Martine Croisy-Delcey、Emile Bisagni

  DOI：10.1021/jm00363a022

  日期：1983.9

  Three types of aza analogues of lucanthone were synthesized for evaluation as antitumor drugs. None of the compounds was found to have significant cytotoxic effects either on Friend tumor cells or on L1210 leukemia cells. However, one of the target compounds, 5,10-dihydro-10-oxo-1-[[3-(diethylamino)propyl]amino]-3-methylpyrido [4,3-b]quinoline, was shown to have noticeable antibiotic properties.