Phenanthro[ 1,2-b]furan-2-carbaldehyde | 103963-13-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: Phenanthro[ 1,2-b]furan-2-carbaldehyde
• 英文别名: Phenanthro[1,2-b]furan-2-carbaldehyde；naphtho[1,2-g][1]benzofuran-2-carbaldehyde
• CAS: 103963-13-9
• 化学式: C₁₇H₁₀O₂
• 分子量: 246.265
• InChiKey: AZRBQZDBFJEIOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  Phenanthro[ 1,2-b]furan-2-carbaldehyde 、 phenanthro[1,2-b]thiophene-2-methanol 以 dichloromethane hexane 为溶剂， 以gave a 82.9% yield of phenanthro[1,2-b]thiophene-2-carbaldehyde, mp 209°-210°, (C,H,S), (CH2Cl2 /hexane)的产率得到phenanthro[1,2-b]thiophene-2-carbaldehyde
  参考文献：
  名称：

  Tetracyclic phenanthro furan heterocyclic derivatives compositions and

  摘要：

  本发明涉及式(I)的抗肿瘤化合物，或其单甲基或单乙基醚（式(I)的化合物包括这些醚，在总共不超过29个碳原子的情况下）；醚，酯；酸盐加成物；其中Ar是由5元环和6元环组成的融合四环芳香环系统，并含有至少一个杂原子和3个芳香环，总共不超过18个环原子，或其取代衍生物；杂原子最好是氧、硫或氮；当它是氮时，它被氢、甲基或乙基取代；R1含有不超过八个碳原子，是一个基团##STR1##其中m为O或1；R5为氢；R6和R7相同或不同，每个都是氢或C1-5烷基，可选地被羟基取代；R8和R9相同或不同，每个都是氢或C1-3烷基；--C--C--是一个五元或六元饱和碳环；R10为氢、甲基或羟甲基；R11、R12和R13相同或不同，每个都是氢或甲基；R14为氢、甲基、羟基或羟甲基。

  公开号：

  US04918101A1
• 作为产物：
  描述：

  Phenanthro<1.2-b>furan-2-carbonsaeure-ethylester 在 barium manganate 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 Phenanthro[ 1,2-b]furan-2-carbaldehyde
  参考文献：
  名称：

  Phenanthro[2,3-6]thiophene derivatives, pharmaceutical compositions and

  摘要：

  该发明涉及式（I）ArCH.sub.2 R.sup.1（I）的抗肿瘤化合物或其单甲基或单乙基醚（式（I）的化合物包括这些醚，总共不超过29个碳原子）；醚，酯；酸盐；其中Ar是由5-和6-成员环组成的融合四环芳香环系统，含有至少一个杂原子和3个芳香环，总共不超过18个环原子，或其取代衍生物；杂原子优选是氧、硫或氮；当它是氮时，它被氢、甲基或乙基取代；R.sup.1含有不超过八个碳原子，是一个基团##STR1##其中m为0或1；R.sup.5为氢；R.sup.6和R.sup.7相同或不同，每个是氢或C.sub.1-5烷基，可选择地被羟基取代；R.sup.8和R.sup.9相同或不同，每个是氢或C.sub.1-3烷基；##STR2##是一个五元或六元饱和碳环；R.sup.10为氢、甲基或羟甲基；R.sup.11、R.sup.12和R.sup.13相同或不同，每个是氢或甲基；R.sup.14为氢、甲基、羟基或羟甲基。

  公开号：

  US04910218A1

文献信息

• Certain substituted naphthofurans with anti-tumor properties
  申请人：Burroughs Wellcome Co.

  公开号：US05008286A1

  公开（公告）日：1991-04-16

  The present invention relates to compounds of formula (I) ArCH.sub.2 R.sup.1 (I) or a monomethyl or monethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon atoms in total); ethers, esters thereof; acide addition salts thereof; wherein Ar is a fused tricyclic aromatic ring system containing a maximum of 14 ring atoms and at least one heteroatom or a fused pentacyclic ring system with at least 4 aromatic rings containing a maximum of 22 ring atoms and at least one heteroatom; or a substituted derivative thereof; for either the tricyclic or pentacyclic ring system there is a maximum of one heteroatom for each ring present but preferably only one or two of the rings contain a heteroatom; the rings forming the tricyclic or the pentacyclic ring system contain five or six atoms; the heteroatoms are conveniently nitrogen, phosphorus, oxygen, sulfur or selenium; suitably the heteroatom is oxygen, sulfur or nitrogen; the tricyclic or the pentacyclic ring system should be planar or deviate only slightly from planarity; suitably the ring system is aromatic or contains one non-aromatic ring; preferably the ring system is aromatic; nitrogen atoms contained in five-membered rings are substituted by hydrogen, methyl or ethyl; R.sup.1 contains not more than eight carbon atoms and is a group ##STR1## wherein m is 0 or 1; R.sup.5 is hydrogen; R.sup.6 and R.sup.7 are the same or different and each is hydrogen or C.sub.1-5 alkyl optionally substituted by hydroxy; R.sup.8 and R.sup.9 are the same or different and each is hydrogen or C.sub.1-3 alkyl; ##STR2## is a five or six-membered saturated carbocyclic ring; R.sup.10 is hydrogen, methyl or hydroxymethyl; R.sup.11, R.sup.12 and R.sup.13 are the same or different and each is hydrogen or methyl; R.sup.14 is hydrogen, methyl, hydroxy, or hydroxymethyl. The compounds have biocidal properties.

  本发明涉及化合物的公式（I）ArCH.sub.2 R.sup.1（I）或其单甲基或单乙基醚（公式（I）的化合物包括这些醚，总共不超过29个碳原子）；醚，酯；酸盐；其中Ar是含有最多14个环原子和至少一个杂原子的融合三环芳香环系统或至少4个芳香环的含有最多22个环原子和至少一个杂原子的融合五环系统；或其取代衍生物；对于三环或五环系统，每个环最多有一个杂原子，但最好只有一个或两个环含有杂原子；形成三环或五环系统的环包含五个或六个原子；杂原子方便地是氮、磷、氧、硫或硒；适宜的杂原子是氧、硫或氮；三环或五环系统应该是平面的或仅略微偏离平面；合适的环系统是芳香的或包含一个非芳香环；最好环系统是芳香的；五元环中含氮原子被氢、甲基或乙基取代；R.sup.1含有不超过八个碳原子，是一个基团##STR1##其中m为0或1；R.sup.5是氢；R.sup.6和R.sup.7相同或不同，每个是氢或C.sub.1-5烷基，可选择地被羟基取代；R.sup.8和R.sup.9相同或不同，每个是氢或C.sub.1-3烷基；##STR2##是一个五元或六元饱和碳环；R.sup.10是氢、甲基或羟甲基；R.sup.11、R.sup.12和R.sup.13相同或不同，每个是氢或甲基；R.sup.14是氢、甲基、羟基或羟甲基。这些化合物具有杀生物性能。
• Benzo[c]carbazole propanediol compound and salts thereof
  申请人：Burroughs Wellcome Co.

  公开号：US04797495A1

  公开（公告）日：1989-01-10

  The present invention relates to compounds of formula (I) ArCH.sub.2 R.sup.1 (I) or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wherein Ar is a fused tetracyclic aromatic ring system comprised of 5-membered and 6-membered rings and contains at least one heteroatom and 3 aromatic rings and a total of no more than 18 ring atoms, or a substituted derivative thereof; the heteroatom is preferably oxygen, sulfur or nitrogen; when it is nitrogen this is substituted by hydrogen, methyl or ethyl; R.sup.1 contains not more than eight carbon atoms and is a group ##STR1## wherein m is 0 or 1; R.sup.5 is hydrogen; R.sup.6 and R.sup.7 are the same or different and each is hydrogen or C.sub.1-5 alkyl optionally substituted by hydroxy; R.sup.8 and R.sup.9 are the same or different and each is hydrogen or C.sub.1-3 alkyl; ##STR2## is a five or six-membered saturated carbocyclic ring; R.sup.10 is hydrogen, methyl or hydroxymethyl; R.sup.11, R.sup.12 and R.sup.13 are the same or different and each is hydrogen or methyl; R.sup.14 is hydrogen, methyl, hydroxy, or hydroxymethyl.

  本发明涉及化合物的公式（I）ArCH.sub.2R.sup.1（I）或其单甲基或单乙基醚（公式（I）的化合物包括这些醚，在总共不超过29个碳原子中）; 它们的醚，酯; 酸加成盐; 其中Ar是由5个和6个成员环组成的融合四环芳香环系统，包含至少一个杂原子和3个芳香环，总环原子数不超过18，或其取代衍生物; 杂原子最好是氧，硫或氮; 当它是氮时，它被氢，甲基或乙基取代; R.sup.1不含超过八个碳原子，是一个组##STR1##其中m为0或1; R.sup.5是氢; R.sup.6和R.sup.7相同或不同，每个是氢或C.sub.1-5烷基，可选地被羟基取代; R.sup.8和R.sup.9相同或不同，每个是氢或C.sub.1-3烷基; ##STR2##是一个五元或六元饱和碳环; R.sup.10是氢，甲基或羟甲基; R.sup.11，R.sup.12和R.sup.13相同或不同，每个是氢或甲基; R.sup.14是氢，甲基，羟基或羟甲基。
• Tetracyclic phenanthro furan heterocyclic derivatives compositions and
  申请人：Burroughs Wellcome Co.

  公开号：US04918101A1

  公开（公告）日：1990-04-17

  The present invention relates to antitumor compounds of formula (I) ArCH.sub.2 R.sup.1 (I) or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wherein Ar is a fused tetracyclic aromatic ring system comprised of 5-membered and 6-membered rings and contains at least one heteroatom and 3 aromatic rings and a total of no more than 18 ring atoms, or a substituted derivative thereof; the heteroatom is preferably oxygen, sulfur or nitrogen; when it is nitrogen this is substituted by hydrogen, methyl or ethyl; R.sup.1 contains not more than eight carbon atoms and is a group ##STR1## wherein m is O or 1; R.sup.5 is hydrogen; R.sup.6 and R.sup.7 are the same or different and each is hydrogen or C.sub.1-5 alkyl optionally substituted by hydroxy; R.sup.8 and R.sup.9 are the same or different and each is hydrogen or C.sub.1-3 alkyl; --C--C-- is a five or six-membered saturated carbocyclic ring; R.sup.10 is hydrogen, methyl or hydroxymethyl; R.sup.11, R.sup.12 and R.sup.13 are the same or different and each is hydrogen or methyl; R.sup.14 is hydrogen, methyl, hydroxy, or hydroxymethyl.

  本发明涉及式(I)的抗肿瘤化合物，或其单甲基或单乙基醚（式(I)的化合物包括这些醚，在总共不超过29个碳原子的情况下）；醚，酯；酸盐加成物；其中Ar是由5元环和6元环组成的融合四环芳香环系统，并含有至少一个杂原子和3个芳香环，总共不超过18个环原子，或其取代衍生物；杂原子最好是氧、硫或氮；当它是氮时，它被氢、甲基或乙基取代；R1含有不超过八个碳原子，是一个基团##STR1##其中m为O或1；R5为氢；R6和R7相同或不同，每个都是氢或C1-5烷基，可选地被羟基取代；R8和R9相同或不同，每个都是氢或C1-3烷基；--C--C--是一个五元或六元饱和碳环；R10为氢、甲基或羟甲基；R11、R12和R13相同或不同，每个都是氢或甲基；R14为氢、甲基、羟基或羟甲基。
• Benzo[c]curbazole derivatives, compositions and use
  申请人：Burroughs Wellcome Co.

  公开号：US04952597A1

  公开（公告）日：1990-08-28

  The present invention related to anti tumor compounds of formula (I) ArCH.sub.2 R.sup.1 (I) or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wherein Ar is a fused tetracyclic aromatic ring system comprised of 5-membered and 6-membered rings and contains at least one heteroatom and 3 aromatic rings and a total of no more than 18 ring atoms, or a substituted derivative thereof; the heteratom is preferably oxygen, sulfur or nitrogen; when it is nitrogen this is substituted by hydrogen, methyl or ethyl; R.sup.1 contains not more than eight carbon atoms and is a group ##STR1## wherein m is 0 or 1; R.sup.5 is hydrogen; R.sup.6 and R.sup.7 are the same or different and each is hydrogen or C.sub.1-5 alkyl optionally substituted by hydroxy; R.sup.8 and R.sup.9 are the same or different and each is hydrogen or C.sub.1-3 alkyl; ##STR2## is a five or six-membered saturated carbocyclic ring; R.sup.10 is hydrogen, methyl or hydroxymethyl; R.sup.11, R.sup.12 and R.sup.13 are the same or different and each is hydrogen or methyl; R.sup.14 is hydrogen, methyl, hydroxy, or hydroxymethyl.

  本发明涉及化合物的抗肿瘤化合物的公式（I）ArCH.sub.2R.sup.1（I）或其单甲基或单乙基醚（公式（I）的化合物包括这些醚，总共不超过29个碳原子）；醚，酯；其酸加成盐；其中Ar是由5个成员和6个成员的环组成的融合四环芳香环系统，并包含至少一个杂原子和3个芳香环，总环原子数不超过18个，或其取代衍生物；杂原子最好是氧，硫或氮；当它是氮时，它被氢，甲基或乙基取代；R.sup.1含有不超过八个碳原子，并且是一个组##STR1##其中m为0或1；R.sup.5为氢；R.sup.6和R.sup.7相同或不同，每个都是氢或C.sub.1-5烷基，可选地被羟基取代；R.sup.8和R.sup.9相同或不同，每个都是氢或C.sub.1-3烷基；##STR2##是一个五个或六个成员的饱和碳环；R.sup.10是氢，甲基或羟甲基；R.sup.11，R.sup.12和R.sup.13相同或不同，每个都是氢或甲基；R.sup.14是氢，甲基，羟基或羟甲基。
• Dibenzothiphene and naphthalenethiophene derivatives
  申请人：Burroughs Wellcome Co.

  公开号：US04965285A1

  公开（公告）日：1990-10-23

  The present invention relates to compounds of formula (I) ArCH.sub.2 R.sup.1 (I) or a monomethyl or monoethyl ether thereof (the compound of formula (I) including these ethers may contain no more than 29 carbon atoms in total); ethers, esters thereof; acid addition salts thereof; wherein Ar is a fused tricyclic aromatic ring system containing a maximum of 14 ring atoms and at least one heteroatom or a fused pentacyclic ring system with at least 4 aromatic rings containing a maximum of 22 ring atoms and at least one heteroatom; or a substituted derivative thereof; for either the tricyclic or pentacyclic ring system there is a maximum of one heteroatom for each ring present but preferably only one or two of the rings contain a heteroatom; the rings forming the tricyclic or the pentacyclic ring system contain five or six atoms; the heteroatoms are conveniently nitrogen, phosphorus, oxygen, sulfur or selenium; suitably the heteroatom is oxygen, sulfur or nitrogen; the tricyclic or the pentacyclic ring system should be planar or deviate only slightly from planarity; suitably the ring system is aromatic or contains one non-aromatic ring; preferably the ring system is aromatic; nitrogen atoms contained in five-membered rings are substituted by hydrogen, methyl or ethyl; R.sup.1 contains not more than eight carbon atoms and is a group ##STR1## wherein m is 0 or 1; R.sup.5 is hydrogen; R.sup.6 and R.sup.7 are the same or different and each is hydrogen or C.sub.1-5 alkyl optionally substituted by hydroxy; R.sup.8 and R.sup.9 are the same or different and each is hydrogen or C.sub.1-3 alkyl; ##STR2## is a five or six-membered saturated carbocyclic ring; R.sup.10 is hydrogen, methyl or hydroxymethyl; R.sup.11, R.sup.12 and R.sup.13 are the same or different and each is hydrogen or methyl; R.sup.14 is hydrogen, methyl, hydroxy, or hydroxymethyl.

  本发明涉及式（I）ArCH.sub.2R.sup.1（I）的化合物或其单甲基或单乙基醚（式（I）的化合物包括这些醚，在总共不超过29个碳原子的情况下）；它们的醚，酯；酸加成盐；其中Ar是一个融合的三环芳香环系统，最多包含14个环原子和至少一个杂原子，或者是一个融合的五环芳香环系统，至少有4个芳香环，最多包含22个环原子和至少一个杂原子；或其取代衍生物；对于三环或五环环系统，每个存在的环中最多只有一个杂原子，但最好只有一个或两个环含有杂原子；形成三环或五环环系统的环包含五个或六个原子；杂原子方便地是氮、磷、氧、硫或硒；适当的杂原子是氧、硫或氮；三环或五环环系统应是平面的或仅略微偏离平面；适当的环系统是芳香的或含有一个非芳香环；最好的环系统是芳香的；五元环中含有的氮原子被氢、甲基或乙基取代；R.sup.1含有不超过八个碳原子，是一个组##STR1##其中m为0或1；R.sup.5是氢；R.sup.6和R.sup.7相同或不同，每个是氢或C.sub.1-5烷基，可选择地被羟基取代；R.sup.8和R.sup.9相同或不同，每个是氢或C.sub.1-3烷基；##STR2##是一个五元或六元饱和碳环；R.sup.10是氢、甲基或羟甲基；R.sup.11、R.sup.12和R.sup.13相同或不同，每个是氢或甲基；R.sup.14是氢、甲基、羟基或羟甲基。