4-(2,4-dimethoxy-5-propyl-phenyl)-4-oxo-butyric acid | 36674-12-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(2,4-dimethoxy-5-propyl-phenyl)-4-oxo-butyric acid
• 英文别名: 4-(2,4-Dimethoxy-5-propyl-phenyl)-4-oxo-buttersaeure；4-(2,4-dimethoxy-5-propylphenyl)-4-oxobutanoic acid
• CAS: 36674-12-1
• 化学式: C₁₅H₂₀O₅
• 分子量: 280.321
• InChiKey: DJWLQWKXKIFOLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  20.0
• 可旋转键数：
  8.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  72.83
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  4-(2,4-dimethoxy-5-propyl-phenyl)-4-oxo-butyric acid 以 甲苯 为溶剂， 生成 4-(2,4-dimethoxy-5-propylphenyl)butanoic acid
  参考文献：
  名称：

  Andotra; Kumar, Journal of the Indian Chemical Society, 1990, vol. 67, # 1, p. 76 - 77

  摘要：

  DOI：
• 作为产物：
  描述：

  间苯二酚 在 三氯化铝 作用下， 以 硝基苯 为溶剂， 生成 4-(2,4-dimethoxy-5-propyl-phenyl)-4-oxo-butyric acid
  参考文献：
  名称：

  Andotra; Kumar, Journal of the Indian Chemical Society, 1990, vol. 67, # 1, p. 76 - 77

  摘要：

  DOI：

文献信息

• Irani; Phalnikar; Nargund, Journal of the University of Bombay, Science: Physical Sciences, Mathematics, Biological Sciences and Medicine, 1948, vol. 16/5 A, p. 41
  作者：Irani、Phalnikar、Nargund

  DOI：——

  日期：——
• Turner’s syndrome mosaicism 45X/47XXX: An interesting natural history
  作者：L. Tauchmanovà、Riccardo Rossi、M. Pulcrano、L. Tarantino、C. Baldi、G. Lombardi

  DOI：10.1007/bf03343932

  日期：2001.11

  Mosaicism 45X/47XXX is a sporadic form of ovarian dysgenesis. Many of the cases previously described were characterized by a variable phenotype expression. We here report the case of a 33-yr-old woman with recent secondary amenorrhea, weight loss and breast regression. Her menarche had occurred at the age of 11 yr and 6 months and her menstrual cycles had been regular until the age of 28; then, oligomenorrhea and hypertricosis developed. A pelvic ultrasound showed enlarged polycystic-like ovaries and normal uterus. She was treated with ethynil-estradiol and cyproterone acetate for one year. At the age of 31 yr, she underwent a pelvic ultrasound - which revealed normal volume of the ovaries - and hormonal assays including FSH (69 UI/I), LH (113 UI/I), 17 beta -estradiol (88 pg/ml), plasma androgens and cortisol levels within normal ranges. No organ-specific autoantibodies toward ovaries, steroid-producing cells or adrenals were found. At the age of 33 yr, there was ultrasound evidence of streak-like ovaries. The patient's height was 145 cm and her weight 45 kg. She had normal female external genitalia, abnormal upper-to-lower body segment ratio, webbed neck, low posterior hair line, cubitus valgus, short and asymmetrical 4(th) metacarpi, hallux with lateral deviation and moderate scoliosis. No increase in ovarian steroids were found after GnRH-analogue triptorelin (0,1 mg sc) administration. The karyotype analysis on peripheral blood lymphocytes showed a mosaic 45X (90% cells) and 47XXX (10% cells). Diagnostic pelviscopy confirmed streak gonads. Chronic lymphocytic thyroiditis was diagnosed but no cardiovascular or kidney abnormalities were found. A neuro-psychological evaluation revealed emotional and social immaturity, disorders in motorial coordination, visual-spatial organization, as well as reading difficulties and impaired complex phrase construction. The presence of several somatic features of Turner's syndrome, neuro-psychological disorders and an interesting natural history probably depended on the quantitative proportion of 45X to 47XXX cell-lines in different tissues and organs. Estrogen and progestin replacement therapy led to weight gain, re-appearance of secondary sexual characteristics and a mild improvement in mental equilibrium. (C) 2001, Editrice Kurtis.
• ANDOTRA, CHARANJIT SINGH;KUMAR, RAJINDER, J. INDIAN CHEM. SOC., 67,(1990) N, C. 76-77
  作者：ANDOTRA, CHARANJIT SINGH、KUMAR, RAJINDER

  DOI：——

  日期：——