N⁹-carbazolylacetyl hydrazine | 202655-30-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N⁹-carbazolylacetyl hydrazine
• 英文别名: 2-Carbazol-9-ylacetohydrazide
• CAS: 202655-30-9
• 化学式: C₁₄H₁₃N₃O
• mdl: MFCD01179107
• 分子量: 239.277
• InChiKey: KPGXVQYVDFRREV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.071
• 拓扑面积：
  60
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N⁹-carbazolylacetyl hydrazine 在 溶剂黄146 、 zinc(II) chloride 作用下， 以 四氢呋喃 、 氯仿 为溶剂， 反应 20.0h， 生成 2-carbazol-9-yl-N-[2-(2-chlorophenyl)-4-oxo-1,3-thiazolidin-3-yl]acetamide
  参考文献：
  名称：

  Srivastava; Srivastava; Srivastava, Journal of the Indian Chemical Society, 2001, vol. 78, # 6, p. 320 - 322

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 一水合肼 作用下， 生成 N⁹-carbazolylacetyl hydrazine
  参考文献：
  名称：

  An application of fuzzy logic reasoning for GIS temporal modeling of dynamic processes

  摘要：

  The analysis and modeling of dynamic processes require the consideration of both spatial and temporal attributes of data and their integration into a GIS database. However, current GIS raster databases have severe limitations related to the temporal component of data. Data are generally stored through a series of snapshot layers associated to particular instants in time. If the interval between two consecutive snapshots is too long the essential information about the change may remain undetected. In this study, spatio-temporal interpolation based on fuzzy logic theory was applied in order to model the missing information about change that happened between consecutive snapshots. Three different scenarios of rural-to-urban landuse transformation were conceived to simulate different dynamics of change using module FUZZY-TEMP integrated in the GRASS4.1 environment. The obtained results were validated through a comparison of the urban boundaries obtained from aerial photographs and those which were generated using the proposed methodology. The results confirm the potential of the approach to produce realistic simulations of the dynamics of the urbanization process. (C) 2000 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0165-0114(99)00013-5

文献信息

• 咔唑类噁二唑共缀物及其制备方法和应用
  申请人：西南大学

  公开号：CN110330486A

  公开（公告）日：2019-10-15

  本发明涉及咔唑类噁二唑共缀物及其制备方法和应用，属于化学合成技术领域，咔唑类噁二唑共缀物如通式I所示，该类化合物对革兰阳性菌、革兰阴性菌和真菌中的一种或多种具有一定抑制活性，可以用于制备抗细菌和/或抗真菌药物，从而为临床抗微生物治疗提供更多高效、安全的候选药物，有助于解决日趋严重的耐药性、顽固的致病性微生物以及新出现的有害微生物等临床治疗问题。其制备原料简单，廉价易得，合成路线短，对抗感染方面的应用具有重要意义。
• 一种咔唑-靛红型化合物及其制法和用途
  申请人：吉首大学

  公开号：CN105732476B

  公开（公告）日：2017-12-01

  本发明公开了一种咔唑‑靛红型化合物及其制法和用途。该化合物具有如式（I）所示结构，制备方法是以咔唑和溴乙酸乙酯为原料得到2‑(9H‑咔唑‑9‑基)乙酸乙酯，再经肼解反应得到2‑(9H‑咔唑‑9‑基)乙酰肼，最后与各种取代靛红反应得到目标化合物。该化合物可以作为抗肿瘤药物的原料，且制备方法原料简单易得，操作方便。（I）。
• Synthesis, spectral characterization and antitumor activity of phenothiazine derivatives
  作者：Kasi Venkatesan、Vardhineedi Sri Venkata Satyanarayana、Amaravadi Sivakumar、Chitteti Ramamurthy、Chinnasamy Thirunavukkarusu

  DOI：10.1002/jhet.3980

  日期：2020.7

  Different types of phenothiazine derivatives were synthesized by reactions of 10‐alkyl‐10H ‐phenothiazine‐3‐carbaldehydes. Structures of the prepared compounds were confirmed through spectroscopic techniques such as IR, 1H NMR, 13C NMR and mass spectroscopy. All the compounds were studied for their antitumor activities.

  通过10-烷基-10 H-吩噻嗪-3-甲醛的反应合成了不同类型的吩噻嗪衍生物。通过诸如IR，1 H NMR，13 C NMR和质谱的光谱技术确认了所制备化合物的结构。研究了所有化合物的抗肿瘤活性。
• Design, Synthesis and Evaluation of Novel 9-substituted Carbazole Derivatives as Potential Anticancer Agents
  作者：Nitin Kumar、Devender Pathak

  DOI：10.2174/1570180812666150430002118

  日期：2015.9.9

  energy. Above mentioned compounds were synthesized by starting with carbazole and characterized by FTIR, 1H-NMR, 13C-NMR, MASS spectrometry and elemental analysis. All the synthesized compounds were evaluated for their anticancer activity by SRB assay method against Human Breast Cancer Line (MCF7). All the tested compounds showed moderate to good anticancer activity. Compound 3d and 6c exhibited highest

  通过分子对接检查了许多咔唑衍生物对拓扑异构酶的抑制特性，该分子对接由ChemDraw软件设计，然后进行3D优化。两个系列，即2-[（4,5-二氢-2-取代苯基）咪唑-1-基氨基] -1-（9H-咔唑-9-基）乙酮（3a-3e）和2-（9H-咔唑-9发现-yl）-N'-[（4-取代苯基）（哌嗪-1-基）]甲基}乙酰肼（6a-6e）具有最小的结合能。通过以咔唑为原料合成上述化合物，并通过FTIR，1 H-NMR，13表征C-NMR，MASS光谱和元素分析。通过SRB测定法评估所有合成的化合物对人乳腺癌细胞系（MCF7）的抗癌活性。所有测试的化合物均显示出中等至良好的抗癌活性。化合物3d和6c显示出对癌细胞系抑制的最高活性。
• Lodhi, R. S.; Srivastava, S. D., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1997, vol. 36, # 10, p. 947 - 950
  作者：Lodhi, R. S.、Srivastava, S. D.

  DOI：——

  日期：——