2-benzoyl-4,5-dimethoxy-1-(4-methylphenylsulfonamido)benzene | 309927-64-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-benzoyl-4,5-dimethoxy-1-(4-methylphenylsulfonamido)benzene
• 英文别名: N-(2-benzoyl-4,5-dimethoxyphenyl)-4-methylbenzenesulfonamide
• CAS: 309927-64-8
• 化学式: C₂₂H₂₁NO₅S
• 分子量: 411.478
• InChiKey: FSSVEMKIAPRSTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  90.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-benzoyl-4,5-dimethoxy-1-(4-methylphenylsulfonamido)benzene 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 以85%的产率得到N-(4,5-dimethoxy-2-(hydroxy(phenyl)methyl)phenyl)-4-methylbenzenesulfonamide
  参考文献：
  名称：

  Simple route to 3-(2-indolyl)-1-propanones via a furan recyclization reaction

  摘要：

  A simple route to 1-R-3-(2-indolyl)-1-propanones has been elaborated based on recyclization of 2-(2-aminobenzyl)furan derivatives. Being a modification of the Reissert indole synthesis, our approach employs the furan ring as a source of carbonyl function. This approach is general and allows varying of substituents in aromatic ring as well as in 3-position of indole nucleus. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.10.056
• 作为产物：
  描述：

  3,4-二甲氧基二苯甲酮 在 吡啶 、 硝酸 、 铁粉 、 溶剂黄146 作用下， 以 水 、 乙酸乙酯 为溶剂， 反应 7.5h， 生成 2-benzoyl-4,5-dimethoxy-1-(4-methylphenylsulfonamido)benzene
  参考文献：
  名称：

  Simple route to 3-(2-indolyl)-1-propanones via a furan recyclization reaction

  摘要：

  A simple route to 1-R-3-(2-indolyl)-1-propanones has been elaborated based on recyclization of 2-(2-aminobenzyl)furan derivatives. Being a modification of the Reissert indole synthesis, our approach employs the furan ring as a source of carbonyl function. This approach is general and allows varying of substituents in aromatic ring as well as in 3-position of indole nucleus. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.10.056

文献信息

• Electrochemical intramolecular N(sp²)–H/N(sp³)–H coupling for the synthesis of 1<i>H</i>-indazoles
  作者：Qiang Zhong、Pei-Long Wang、Hui Gao、Fang Ma、Youqing Yang、Hongji Li

  DOI：10.1039/d3gc00380a

  日期：——

  The electrochemical synthesis of 1H-indazoles via an intramolecular N(sp2)–H/N(sp3)–H coupling reaction at room temperature is first described. The transition metal-free electrochemical cyclization features the use of commercially available NH3 as the nitrogen source and a broad substrate scope, thus affording a wide range of substituted 1H-indazoles in moderate to good yields. Both the control experiments

  首先描述了在室温下通过分子内 N(sp 2 )–H/N(sp 3 )–H 偶联反应电化学合成 1 H-吲唑。无过渡金属电化学环化的特点是使用市售的 NH 3作为氮源和广泛的底物范围，从而以中等到良好的产率提供范围广泛的取代 1 H-吲唑。控制实验和机理研究都支持所提出的这种电化学环化反应机理。
• Simple route to 3-(2-indolyl)-1-propanones via a furan recyclization reaction
  作者：Alexander V. Butin、Sergey K. Smirnov、Tatyana A. Stroganova、Wolfgang Bender、Gennady D. Krapivin

  DOI：10.1016/j.tet.2006.10.056

  日期：2007.1

  A simple route to 1-R-3-(2-indolyl)-1-propanones has been elaborated based on recyclization of 2-(2-aminobenzyl)furan derivatives. Being a modification of the Reissert indole synthesis, our approach employs the furan ring as a source of carbonyl function. This approach is general and allows varying of substituents in aromatic ring as well as in 3-position of indole nucleus. (c) 2006 Elsevier Ltd. All rights reserved.