<2R,3R,4R,5R>-2-Benzyloxymethyl-3,4-dihydroxy-8-(4-methoxybenzyl)-1-oxa-6,8-diazaspiro<4.4>nonane-7,9-dione | 130606-99-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: <2R,3R,4R,5R>-2-Benzyloxymethyl-3,4-dihydroxy-8-(4-methoxybenzyl)-1-oxa-6,8-diazaspiro<4.4>nonane-7,9-dione
• 英文别名: (5R,7R,8R,9R)-8,9-dihydroxy-3-[(4-methoxyphenyl)methyl]-7-(phenylmethoxymethyl)-6-oxa-1,3-diazaspiro[4.4]nonane-2,4-dione
• CAS: 130606-99-4
• 化学式: C₂₂H₂₄N₂O₇
• 分子量: 428.442
• InChiKey: HFHQGVQRMVKQFL-VQQMMKBISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.78
• 重原子数：
  31.0
• 可旋转键数：
  7.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  117.56
• 氢给体数：
  3.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  <2R,3R,4R,5R>-2-Benzyloxymethyl-3,4-dihydroxy-8-(4-methoxybenzyl)-1-oxa-6,8-diazaspiro<4.4>nonane-7,9-dione 在 ammonium cerium(IV) nitrate 作用下， 以 水 、 乙腈 为溶剂， 生成
  参考文献：
  名称：

  Synthetic studies on (+)-hydantocidin (2): Aldol addition approaches toward the stereoisomers of (+)-hydantocidin

  摘要：

  The spiro-hydantoin ring at the anomeric position of D-and L-furanose was constructed by using aldol addition followed by acid promoted cyclization and the synthesis of thestereoisomers of (+)-hydantocidin, L- and D-series of spiro-furanose 2, 3, 4 and 5.

  DOI：

  10.1016/s0040-4020(01)96123-x
• 作为产物：
  描述：

  <2S,3R,4R,5S>-2-Benzyloxymethyl-4-t-butyldimethylsilyloxy-3-hydroxy-8-(4-methoxybenzyl)-6,8-diaza-1-oxaspiro<4.4>nonane-7,9-dione 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 生成 <2R,3R,4R,5R>-2-Benzyloxymethyl-3,4-dihydroxy-8-(4-methoxybenzyl)-1-oxa-6,8-diazaspiro<4.4>nonane-7,9-dione
  参考文献：
  名称：

  Synthetic studies on (+)-hydantocidin (2): Aldol addition approaches toward the stereoisomers of (+)-hydantocidin

  摘要：

  The spiro-hydantoin ring at the anomeric position of D-and L-furanose was constructed by using aldol addition followed by acid promoted cyclization and the synthesis of thestereoisomers of (+)-hydantocidin, L- and D-series of spiro-furanose 2, 3, 4 and 5.

  DOI：

  10.1016/s0040-4020(01)96123-x

文献信息

• Synthetic studies on (+)-hydantocidin (4): Synthesis of stereoisomers of (+)-hydantocidin
  作者：Shigeru Mio、Masumi Ueda、Masae Hamura、Junko Kitagawa、Soji Sugai

  DOI：10.1016/s0040-4020(01)96125-3

  日期：——

  The stereoisomers of (+)-hydantocidin were synthesized by diastereoselective dihydroxylation directly or epoxidation followed by ring opening of 1-oxa-6,8-diazaspiro[4.4]nonane-3-ene-7,9-dione systems.