(R)-N-[(1S)-1-(1-ethyl-1H-pyrazol-4-yl)-3-butenyl]-2-methyl-2-propanesulfinamide | 1609247-43-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (R)-N-[(1S)-1-(1-ethyl-1H-pyrazol-4-yl)-3-butenyl]-2-methyl-2-propanesulfinamide
• CAS: 1609247-43-9
• 化学式: C₁₃H₂₃N₃OS
• 分子量: 269.411
• InChiKey: HTPOEHXCMFWKKJ-KPZWWZAWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.57
• 重原子数：
  18.0
• 可旋转键数：
  6.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  46.92
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  (R)-N-[(1S)-1-(1-ethyl-1H-pyrazol-4-yl)-3-butenyl]-2-methyl-2-propanesulfinamide 在 盐酸 作用下， 以 1,4-二氧六环 、 甲醇 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  Diastereoselective In and Zn-mediated allylation of pyrazol-4-yl derived (R)-tert-butanesulfinyl imines: synthesis of enantiomerically pure 6-(pyrazol-4-yl)-piperidin-2,4-diones

  摘要：

  The In and Zn-mediated allylation of substituted pyrazol-4-yl derived (R)-N-tert-butanesulfinyl imines proceeds with high diastereoselectivity depending on the conditions and additives (up to 99.4% de). Thus, the synthesized diastereomeric homoallylsulfinamides were isolated and characterized as pure diastereomers, which were then converted into the corresponding pyrazol-4-yl-derived N-Boc-homoallylamines via consecutive treatment with HCl and Boc(2)O. The latter were then subjected to a sequence of reactions: cyclobromocarbamation with NBS and enolateisocyanate rearrangement with tBuOK to give novel enantiomerically pure (S)-6-(pyrazol-4-yl)-piperidine-2,4-diones in 88-96% yield. The absolute configurations of the allylation products were assigned by X-ray single crystal analysis of the intermediate bromomethylurethanes. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2014.03.003
• 作为产物：
  描述：

  1-乙基-1H-吡唑-4-甲醛 在 titanium(IV) isopropylate 、 锌 作用下， 以 四氢呋喃 为溶剂， 反应 20.5h， 生成 (R)-N-[(1S)-1-(1-ethyl-1H-pyrazol-4-yl)-3-butenyl]-2-methyl-2-propanesulfinamide
  参考文献：
  名称：

  Diastereoselective In and Zn-mediated allylation of pyrazol-4-yl derived (R)-tert-butanesulfinyl imines: synthesis of enantiomerically pure 6-(pyrazol-4-yl)-piperidin-2,4-diones

  摘要：

  The In and Zn-mediated allylation of substituted pyrazol-4-yl derived (R)-N-tert-butanesulfinyl imines proceeds with high diastereoselectivity depending on the conditions and additives (up to 99.4% de). Thus, the synthesized diastereomeric homoallylsulfinamides were isolated and characterized as pure diastereomers, which were then converted into the corresponding pyrazol-4-yl-derived N-Boc-homoallylamines via consecutive treatment with HCl and Boc(2)O. The latter were then subjected to a sequence of reactions: cyclobromocarbamation with NBS and enolateisocyanate rearrangement with tBuOK to give novel enantiomerically pure (S)-6-(pyrazol-4-yl)-piperidine-2,4-diones in 88-96% yield. The absolute configurations of the allylation products were assigned by X-ray single crystal analysis of the intermediate bromomethylurethanes. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2014.03.003