4,4-Dimethyl-2-heptanone | 127130-61-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4,4-Dimethyl-2-heptanone
• 英文别名: 4,4-Dimethylheptan-2-one
• CAS: 127130-61-4
• 化学式: C₉H₁₈O
• 分子量: 142.241
• InChiKey: DBJPSQMMWIWBCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4,4-Dimethyl-2-heptanone 生成 N-[(E)-4,4-dimethylheptan-2-ylideneamino]-4-methylbenzenesulfonamide
  参考文献：
  名称：

  FREEMAN, PETER K.;DACZHMMETRNINO, JOSE S.;STEVENSON, BRIAN K.;SLARR, GARU+, J. ORG. CHEM., 55,(1990) N2, C. 3867-3875

  摘要：

  DOI：
• 作为产物：
  描述：

  4,4-dimethyl-6-heptyn-2-one 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 反应 1.25h， 以74%的产率得到4,4-Dimethyl-2-heptanone
  参考文献：
  名称：

  Chemistry of 1-carbena-5-hexyne and related intermediates

  摘要：

  DOI：

  10.1021/jo00299a032

文献信息

• PRODRUGS OF NH-ACIDIC COMPOUNDS: ESTER, CARBONATE, CARBAMATE AND PHOSPHONATE DERIVATIVES
  申请人：Blumberg Laura Cook

  公开号：US20110319422A1

  公开（公告）日：2011-12-29

  The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.

  该发明提供了一种持续释放内酰胺、亚酰胺、酰胺、磺胺、碳酸酯或尿素含有母药的方法，通过向患者施用该发明的一种前药化合物的有效量，在向患者施用后，从前药中释放母药是持续释放的。适用于该发明方法的前药化合物是母药的不稳定结合物，通过羰基连接的前药基团进行衍生化。该发明的前药化合物可用于治疗任何需要内酰胺、亚酰胺、酰胺、磺胺、碳酸酯或尿素含有母药作为治疗的情况。
• Prodrugs of NH-Acidic Compounds: Ester, Carbonate, Carbamate and Phosphonate Derivatives
  申请人：Alkermes Pharma Ireland Limited

  公开号：US20150320875A1

  公开（公告）日：2015-11-12

  The invention provides a method of sustained delivery of a lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug by administering to a patient an effective amount of a prodrug compound of the invention wherein upon administration to the patient, release of the parent drug from the prodrug is sustained release. Prodrug compounds suitable for use in the methods of the invention are labile conjugates of parent drugs that are derivatized through carbonyl linked prodrug moieties. The prodrug compounds of the invention can be used to treat any condition for which the lactam, imide, amide, sulfonamide, carbamate or urea containing parent drug is useful as a treatment.

  本发明提供了一种持续释放内酰胺、亚胺、酰胺、磺酰胺、氨基甲酸酯或尿素含量的母药的方法，通过向患者施用本发明的前药化合物的有效量，在患者体内释放母药的速率是持续释放的。适用于本发明方法的前药化合物是通过羰基偶联的前药基团衍生的母药的不稳定结合物。本发明的前药化合物可用于治疗任何需要内酰胺、亚胺、酰胺、磺酰胺、氨基甲酸酯或尿素含量的母药治疗的疾病。
• Process for producing alcohols and ketones
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0531715A1

  公开（公告）日：1993-03-17

  The present invention provides a process for the oxidation of straight-chain, branched-chain or cyclic alkanes of 1-20 carbon atoms and benzene derivatives represented by the following formulas (1) - (2). The alcohols and ketones obtained by the oxidation of the alkanes mentioned above and those by the oxidation of the benzene derivatives mentioned above represented by the following formulas (3) - (6) are important as basic starting materials in producing various chemical products including resins, such as nylon and polyester, pharmaceuticals, agricultural chemicals, perfumes, dyes, etc.

  本发明提供了一种氧化 1-20 个碳原子的直链、支链或环状烷烃以及由下列式子 (1) - (2) 表示的苯衍生物的工艺。由上述烷烃氧化得到的醇和酮以及由下列式子（3）-（6）表示的上述苯衍生物氧化得到的醇和酮是生产各种化学产品的重要基本起始原料，包括树脂（如尼龙和聚酯）、药品、农药、香水、染料等。
• HCV/HIV inhibitors and their uses
  申请人：Novartis AG

  公开号：EP2518079A2

  公开（公告）日：2012-10-31

  The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of HCV and associated disorders.

  本申请介绍了可用于治疗、预防和/或改善丙型肝炎病毒及相关疾病的有机化合物。
• FREEMAN, PETER K.;DACZHMMETRNINO, JOSE S.;STEVENSON, BRIAN K.;SLARR, GARU+, J. ORG. CHEM., 55,(1990) N2, C. 3867-3875
  作者：FREEMAN, PETER K.、DACZHMMETRNINO, JOSE S.、STEVENSON, BRIAN K.、SLARR, GARU+

  DOI：——

  日期：——