1-(7-Methyl-1,2,3,5-tetrahydro-1,4-benzodiazepin-4-yl)ethanone | 422318-35-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 1-(7-Methyl-1,2,3,5-tetrahydro-1,4-benzodiazepin-4-yl)ethanone
• CAS: 422318-35-2
• 化学式: C₁₂H₁₆N₂O
• 分子量: 204.272
• InChiKey: OTLUIQLBIIUKGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(7-Methyl-1,2,3,5-tetrahydro-1,4-benzodiazepin-4-yl)ethanone 在 盐酸 、 sodium nitrite 作用下， 生成 1-(7-Methyl-1-nitroso-1,2,3,5-tetrahydro-benzo[e][1,4]diazepin-4-yl)-ethanone
  参考文献：
  名称：

  Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor

  摘要：

  Evaluation of selected compounds from our Corporate Compound Library in a human 5-HT2C receptor binding assay led to the discovery of WAY-629, a cyclohexyl[b][1,4]benzodiazepinoindole (K-i 56nM, E-max 90%), which is selective for the 5-HT2C receptor versus other serotonin receptor subtypes, and dopamine, histamine, adrenergic, and muscarinic receptors. In addition, WAY-629 was active in vivo in a rat model of feeding behavior. An SAR study based on WAY-629 led to compound 11 (K-i 13 nM, E-max 102%). (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.02.100
• 作为产物：
  描述：

  6-甲基靛红酸酐 在 吡啶 、 lithium aluminium tetrahydride 、 TEA 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 96.0h， 生成 1-(7-Methyl-1,2,3,5-tetrahydro-1,4-benzodiazepin-4-yl)ethanone
  参考文献：
  名称：

  Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor

  摘要：

  Evaluation of selected compounds from our Corporate Compound Library in a human 5-HT2C receptor binding assay led to the discovery of WAY-629, a cyclohexyl[b][1,4]benzodiazepinoindole (K-i 56nM, E-max 90%), which is selective for the 5-HT2C receptor versus other serotonin receptor subtypes, and dopamine, histamine, adrenergic, and muscarinic receptors. In addition, WAY-629 was active in vivo in a rat model of feeding behavior. An SAR study based on WAY-629 led to compound 11 (K-i 13 nM, E-max 102%). (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.02.100

文献信息

• [EN] CYCLOALKYL[b][1,4]DIAZEPINO[6,7,1-hi]INDOLES AND DERIVATIVES<br/>[FR] CYCLOALKYL[B][1,4]DIAZEPINO[6,7,1-HI]INDOLES ET DERIVES
  申请人：WYETH CORP

  公开号：WO2002036596A2

  公开（公告）日：2002-05-10

  This invention provides cycloalkyl[1,4] diazepino[6,7,1-hi] indole compounds of the formula (I): or a pharmaceutically acceptable salt thereof, as well as methods and pharmaceutical compositions utilizing them for the treatment or prevention of disorders such as obsessive-compulsive disorder, depression, anxiety, schizophrenia, migraine, sleep disorders, eating disorders, obesity, epilepsy, and spinal cord injury.
• Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor
  作者：Annmarie L. Sabb、Robert L. Vogel、Gregory S. Welmaker、Joan E. Sabalski、Joseph Coupet、John Dunlop、Sharon Rosenzweig-Lipson、Boyd Harrison

  DOI：10.1016/j.bmcl.2004.02.100

  日期：2004.5

  Evaluation of selected compounds from our Corporate Compound Library in a human 5-HT2C receptor binding assay led to the discovery of WAY-629, a cyclohexyl[b][1,4]benzodiazepinoindole (K-i 56nM, E-max 90%), which is selective for the 5-HT2C receptor versus other serotonin receptor subtypes, and dopamine, histamine, adrenergic, and muscarinic receptors. In addition, WAY-629 was active in vivo in a rat model of feeding behavior. An SAR study based on WAY-629 led to compound 11 (K-i 13 nM, E-max 102%). (C) 2004 Elsevier Ltd. All rights reserved.