3-溴-2,4-二氯吡啶 | 144584-32-7

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 3-溴-2,4-二氯吡啶
• 中文别名: 3-溴-2，4-二氯吡啶
• 英文名称: 3-bromo-2,4-dichloropyridine
• CAS: 144584-32-7
• 化学式: C₅H₂BrCl₂N
• 分子量: 226.888
• InChiKey: IEFKJYCTYZMBFL-UHFFFAOYSA-N

物化性质

• 熔点：
  55.5-56.5 °C
• 沸点：
  254.2±35.0 °C(Predicted)
• 密度：
  1.848±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2933399090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335

SDS

Material Safety Data Sheet

---

Section 1. Identification of the substance
Product Name: 3-Bromo-2,4-dichloropyridine
Synonyms:

---

Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

---

Section 3. Composition/information on ingredients.
Ingredient name: 3-Bromo-2,4-dichloropyridine
CAS number: 144584-32-7

---

Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

---

Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

---

Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

---

Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

---

Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

---

Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C5H2BrCl2N
Molecular weight: 226.9

---

Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride, hydrogen bromide.

---

Section 11. Toxicological information
No data.

---

Section 12. Ecological information
No data.

---

Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

---

Section 14. Transportation information
Non-harzardous for air and ground transportation.

---

Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

---

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  3-溴-2,4-二氯吡啶 在 ammonium hydroxide 、 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 、 palladium 10% on activated carbon 、 氢气 、 sodium hydride 、 potassium carbonate 、 三乙胺 、 sodium hydroxide 作用下， 以 1,4-二氧六环 、 甲醇 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 130.0 ℃ 、206.85 kPa 条件下， 反应 56.0h， 生成 N-[7-(4-aminocyclohexyl)-[1,3]thiazolo[4,5-b]pyridin-2-yl]cyclopropanecarboxamide
  参考文献：
  名称：

  JAK INHIBITOR AND USE THEREOF

  摘要：

  本申请公开了一类作为JAK抑制剂的化合物，以及其在制备用于治疗JAK和TYK2相关疾病的药物中的用途。具体地，揭示了一种由式（I）表示的化合物，其异构体或其药用可接受的盐。

  公开号：

  US20210070754A1
• 作为产物：
  描述：

  3-溴-4-羟基-2(1H)-吡啶酮 在 N,N-二甲基甲酰胺 、 三氯氧磷 作用下， 反应 9.0h， 以83%的产率得到3-溴-2,4-二氯吡啶
  参考文献：
  名称：

  实用的 2,3-吡啶前驱体

  摘要：

  摘要 3-溴-2-氯-4-甲氧基吡啶已被开发为实用的2,3-吡啶前体。已发现通过卤素-金属交换从该前体生成的取代的 2,3-吡啶可与 2-甲氧基呋喃和 2-甲基呋喃发生区域选择性反应。

  DOI：

  10.1080/00397919208021549

文献信息

• Triazolopyridine cannabinoid receptor 1 antagonists
  申请人：Sun Chongqing

  公开号：US20070004772A1

  公开（公告）日：2007-01-04

  The present application describes compounds according to Formula I, pharmaceutical compositions comprising at least one compound according to Formula I and optionally one or more additional therapeutic agents, and methods of treatment using the compounds according to Formula I both alone and in combination with one or more additional therapeutic agents. The compounds have the following general formula: including all prodrugs, solvates, pharmaceutically acceptable salts and stereoisomers, wherein R 1 , R 2 , R 3 , R 4 and R 5 are described herein.

  本申请描述了符合I式的化合物，包括至少一种符合I式的化合物和可选地一种或多种额外的治疗剂的药物组合物，以及使用符合I式的化合物进行治疗的方法，无论是单独使用还是与一种或多种额外的治疗剂结合使用。这些化合物具有以下一般式： 包括所有的前药、溶剂化合物、药用盐和立体异构体，其中R1、R2、R3、R4和R5如本文所述。
• Substituted pyridines, their preparation, and their use as pesticides
  申请人：Hoechst Schering AgrEvo GmbH

  公开号：US05723450A1

  公开（公告）日：1998-03-03

  The invention relates to compounds of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are H, halogen, an aliphatic radical or an aromatic radical, X is O, S or optionally substituted imino, Y is a bond or an optionally substituted bivalent hydrocarbon radical and Z is optionally substituted cycloalkyl or cycloalkenyl. The invention furthermore relates to processes for their preparation and their use as pesticides, in particular as insecticides, acaricides and fungicides.

  该发明涉及以下式的化合物：##STR1## 其中R.sup.1、R.sup.2、R.sup.3和R.sup.4为H、卤素、脂肪基或芳香基，X为O、S或可选择取代的亚胺基，Y为键或可选择取代的二价碳氢基，Z为可选择取代的环烷基或环烯基。该发明还涉及它们的制备过程以及它们作为杀虫剂、螨虫剂和杀菌剂的用途。
• [EN] INDOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS<br/>[FR] COMPOSÉS INDOLONES ET UTILISATION DE CES DERNIERS EN TANT QUE MODULATEURS DES RÉCEPTEURS AMPA
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2016176463A1

  公开（公告）日：2016-11-03

  Provided herein are compounds of Formula (I), and pharmaceutically acceptable salts, N-oxides, or solvates thereof, Formula (I). Also provided herein are pharmaceutical compositions, comprising compounds of Formula (I), and methods of using compounds of Formula (I).

  本文提供的是化合物的化学式(I)，以及其药用盐、N-氧化物或溶剂化合物(I)。本文还提供了包含化合物的药物组合物(I)和使用化合物(I)的方法。
• PYRIDONE AMIDES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES
  申请人：Flynn Daniel L.

  公开号：US20120172382A1

  公开（公告）日：2012-07-05

  Compounds useful in the treatment of mammalian cancers and especially human cancers according to Formula I are disclosed. Pharmaceutical compositions and methods of treatment employing the compounds disclosed herein are also disclosed.

  本文揭示了一些公式为I的化合物，对哺乳动物癌症，特别是人类癌症的治疗具有用处。同时还揭示了使用此处所述化合物的制药组合物和治疗方法。
• [EN] MYT1 KINASE INHIBITOR<br/>[FR] INHIBITEUR DE KINASE MYT1<br/>[ZH] 膜缔合酪氨酸和苏氨酸激酶抑制剂
  申请人：SIMCERE ZAIMING PHARMACEUTICAL CO LTD

  公开号：WO2023198199A1

  公开（公告）日：2023-10-19

  提供具有膜缔合酪氨酸和苏氨酸激酶抑制活性的式（I）化合物或其药学上可接受的盐或其药物组合物，以及所述式（I）化合物或其药学上可接受的盐作为膜缔合酪氨酸和苏氨酸激酶抑制剂在用于预防或治疗由膜缔合酪氨酸和苏氨酸激酶介导的疾病，如肿瘤中的用途。