2-methyl-4-oxo-pent-2c-enoic acid | 35504-82-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: 2-methyl-4-oxo-pent-2c-enoic acid
• 英文别名: 2-Methyl-4-oxo-pent-2c-ensaeure；(Z)-2-methyl-4-oxopent-2-enoic acid
• CAS: 35504-82-6
• 化学式: C₆H₈O₃
• 分子量: 128.128
• InChiKey: YUICRCSHEOZHST-ARJAWSKDSA-N

物化性质

• 熔点：
  100 °C
• 沸点：
  100 °C(Press: 0.5 Torr)
• 密度：
  1.136±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-methyl-4-oxo-pent-2c-enoic acid 在 一水合肼 作用下， 生成 西托沙嗪
  参考文献：
  名称：

  Increased hsp22 RNA Levels in Drosophila Lines Genetically Selected for Increased Longevity

  摘要：

  RNAs for the small heat shock protein (hsp) genes hsp22 and hsp23 are induced during Drosophila aging, suggesting that these genes might have specific functions at late ages. To determine if hsp22 and hsp23 gene expression might correlate with life span, RNA levels for these and additional genes were analyzed throughout the adult life span in a set of five outbred "O" lines, which have been genetically selected for increased longevity, and in five matched control "B" lines. Control ribosomal protein genes rp49 and AP3/RpPO RNA levels were similar in O and B lines. In contrast, hsp22 RNA levels were twofold-tenfold higher in all five O lines relative to all five B lines, while hsp23 exhibited a smaller but significant increase. Thus increased hsp22 and hsp23 RNA levels correlate with the increased life span and increased stress resistance of the genetically selected O lines.

  DOI：

  10.1093/gerona/55.11.b552
• 作为产物：
  描述：

  丙酮酸 在 哌啶 、 丙酮 作用下， 生成 2-methyl-4-oxo-pent-2c-enoic acid
  参考文献：
  名称：

  Buchta; Satzinger, Chemische Berichte, 1959, vol. 92, p. 468,470

  摘要：

  DOI：

文献信息

• Methylmaleimidyl polymer derivatives
  申请人：Rosen Perry

  公开号：US20070141021A1

  公开（公告）日：2007-06-21

  Novel N-2-methylmaleirnide pegylating reagents for the site specific pegylation of therapeutically active proteins and methods for such pegylation using said reagents.

  新型N-2-甲基马来酰亚胺聚乙二醇化试剂，用于治疗活性蛋白质的特异位点聚乙二醇化，以及利用该类试剂进行该聚乙二醇化的方法。
• Continuous hydroformylation process
  申请人：DSM N.V.

  公开号：EP1249439A1

  公开（公告）日：2002-10-16

  A continuous hydroformylation process for forming an aldehyde comprising: A) reacting an olefinically unsaturated compound containing from 6 to 30 carbon atoms, carbon monoxide, hydrogen, and a rhodium-bisphosphite ligand complex catalyst to form a reaction mixture B) evaporating at least a portion of said liquid reaction mixture to isolate aldehyde product C) recycling the catalyst after the evaporation, wherein said evaporation is accomplished in a vacuum evaporator with a short mean residence time and a moderate thermal exposure of the liquid reaction mixture in the evaporator.

  一种用于形成醛的连续加氢甲酰化工艺，包括 A) 使含有 6 至 30 个碳原子的烯烃不饱和化合物、一氧化碳、氢和二磷酸铑配位体络合物催化剂反应，形成反应混合物 B) 蒸发所述液态反应混合物的至少一部分，以分离出醛产物 C) 蒸发后回收催化剂、 其中，所述蒸发在真空蒸发器中完成，平均停留时间短，液体反应混合物在蒸发器中的热暴露适中。
• Positive type photosensitive composition
  申请人：Korea Kumho Petrochemical Co. Ltd.

  公开号：EP2292695A1

  公开（公告）日：2011-03-09

  Disclosed is a positive type photosensitive composition including a polyamide derivative being represented by where R1 and R2 independently represent a bivalent to hexavalent aryl group, R3 represents either a hydrogen atom or an alkyl group with 1 to 20 carbon atoms, R4 represents either an alkyl group having a linear structure or an aryl group having a linear structure, R5 represents any one of a bivalent to hexavalent aryl group, an alkyl group having a linear structure, and an aryl group having a linear structure, k and I independently represent an integer of 10 to 1000, n and m independently represent an integer of 0 to 2 (n+m>0), and X represents either a hydrogen atom or an aryl group with 2 to 30 carbon atoms.

  本发明公开了一种阳离子型感光组合物，其中包括一种聚酰胺衍生物，其形式为 其中 R1 和 R2 独立地代表二价至六价芳基，R3 代表氢原子或具有 1 至 20 个碳原子的烷基，R4 代表具有线性结构的烷基或具有线性结构的芳基，R5 代表二价至六价芳基中的任一个、k 和 I 独立地代表 10 至 1000 的整数，n 和 m 独立地代表 0 至 2 的整数（n+m>0），X 代表氢原子或具有 2 至 30 个碳原子的芳基。
• Ring-Chain Tautomerism in 2-(2,2-Dicyano-1-methylethenyl)benzoic Acid and Related Compounds.
  作者：Per Kolsaker、Joe Arukwe、József Barcóczy、Are Wiberg、Anne Kristine Fagerli、Ole Hammerich、Inger Søtofte、Bengt Långström

  DOI：10.3891/acta.chem.scand.52-0490

  日期：——

  Ring-chain tautomerism with slow interconversion (compared with the NMR timescale) was observed in solutions of 2-(2,2-dicyano-1-methylethenyl)benzoic acid (3e), obtained by Knoevenagel condensation of 2-acetylbenzoic acid with malononitrile, forming the ring tautomer 3-dicyanomethyl-3-methylphthalide (4e) in admixture with 3e. Similar condensations of 2-formylbenzoic acid with methyl cyanoacetate or malononitrile give 2-(2-cyano-2-methoxycarbonyl-ethenyl)benzoic acid (3b) and 2-(2,2-dicyanoethenyl)benzoic acid (3d), respectively, which in solution also exhibit the same tautomerism to give the ring tautomers, 3-(cyanomethoxycarbonylmethyl)phthalide (4d) and 3-(dicyanomethyl)phthalide (4d), respectively. Condensation of 2-formylbenzoic acid with dimethyl malonate gave only the ring compound, 3-(dimethoxycarbonylmethyl)phthalide (4a). Attempts to synthezise 2-(2-cyano-2-methoxycarbonyl-1-methylethenyl)benzoic acid (3c) by methylation of the trimethyl silylester of 3b with diazomethane led to the ring form of 3c, viz. 3-cyanomethoxycarbonylmethyl-3-methylphthalide (4c) as an equimolar mixture of two diastereomers. No tautomerism was observed when the benzene ring was replaced by a thiophene ring (7a, 7b and 8) or an aliphatic double bond (9). Solid state spectra (IR and NMR) indicated that all compounds carrying two cyano groups at the double bond, except the aliphatic compound 9, were in the open-chain form, while all the others were in the ring form. Equilibrium studies for compound (3e reversible arrow 4e) indicated increased stability for the chain form 4e with increasing solvent polarity. Determination of the free energy change, Delta G degrees, and of the free energy of activation, Delta G(double dagger), for the tautomerization in deuteriochloroform (using H-1 NMR spectroscopy) indicated that, in this solvent, a concerted process from the starting material 3e to the anion of 4e is taking place. It is also postulated that a similar reaction path is followed in the other solvents used in this investigation, all belonging to the solvent class 'protophobic dipolar aprotic solvents'.
• Jones et al., Journal of the Chemical Society, 1951, p. 48,51
  作者：Jones et al.

  DOI：——

  日期：——