3-(p-cyclopentyl)phenoxyprop-1-ene | 88737-65-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-(p-cyclopentyl)phenoxyprop-1-ene
• 英文别名: 1-Cyclopentyl-4-[(prop-2-en-1-yl)oxy]benzene；1-cyclopentyl-4-prop-2-enoxybenzene
• CAS: 88737-65-9
• 化学式: C₁₄H₁₈O
• 分子量: 202.296
• InChiKey: OXNCFMNNGORTPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-(p-cyclopentyl)phenoxyprop-1-ene 在 palladium on activated charcoal 氨 、 氢气 、 potassium carbonate 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 、 邻二氯苯 为溶剂， 生成
  参考文献：
  名称：

  Aryloxazolidinediones: identification of potent orally active PPAR dual α/γ agonists

  摘要：

  A series of novel aryloxazolidine-2,4-diones was synthesized. A structure-activity relationship study of these compounds led to the identification of potent, orally active PPAR dual alpha/gamma agonists. Based on the results of efficacy studies in the db/db mice model of type 2 diabetes and the desired pharmacokinetic parameters, compound 12 was selected for further profiling. (C) 2003 Published by Elsevier Ltd.

  DOI：

  10.1016/s0960-894x(03)00785-6
• 作为产物：
  描述：

  4-环戊基苯酚 、 3-溴丙烯 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 生成 3-(p-cyclopentyl)phenoxyprop-1-ene
  参考文献：
  名称：

  Aryloxazolidinediones: identification of potent orally active PPAR dual α/γ agonists

  摘要：

  A series of novel aryloxazolidine-2,4-diones was synthesized. A structure-activity relationship study of these compounds led to the identification of potent, orally active PPAR dual alpha/gamma agonists. Based on the results of efficacy studies in the db/db mice model of type 2 diabetes and the desired pharmacokinetic parameters, compound 12 was selected for further profiling. (C) 2003 Published by Elsevier Ltd.

  DOI：

  10.1016/s0960-894x(03)00785-6

文献信息

• Kumar, Surat; Rastogi, Shri Nivas, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1983, vol. 22, # 7, p. 659 - 663
  作者：Kumar, Surat、Rastogi, Shri Nivas

  DOI：——

  日期：——
• KUMAR, SURAT;RASTOGI, SRI, NIVAS, INDIAN J. CHEM., 1983, 22, N 7, 59-663
  作者：KUMAR, SURAT、RASTOGI, SRI, NIVAS

  DOI：——

  日期：——
• Aryloxazolidinediones: identification of potent orally active PPAR dual α/γ agonists
  作者：Ranjit C. Desai、Dominick F. Gratale、Wei Han、Hiroo Koyama、Edward Metzger、Victoria K. Lombardo、Karen L. MacNaul、Thomas W. Doebber、Joel P. Berger、Kwan Leung、Ronald Franklin、David E. Moller、James V. Heck、Soumya P. Sahoo

  DOI：10.1016/s0960-894x(03)00785-6

  日期：2003.10

  A series of novel aryloxazolidine-2,4-diones was synthesized. A structure-activity relationship study of these compounds led to the identification of potent, orally active PPAR dual alpha/gamma agonists. Based on the results of efficacy studies in the db/db mice model of type 2 diabetes and the desired pharmacokinetic parameters, compound 12 was selected for further profiling. (C) 2003 Published by Elsevier Ltd.