N-<(3-indolyl)phenylmethyl>-i-propylamine | 171813-46-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-<(3-indolyl)phenylmethyl>-i-propylamine
• 英文别名: N-[1H-indol-3-yl(phenyl)methyl]propan-2-amine
• CAS: 171813-46-0
• 化学式: C₁₈H₂₀N₂
• 分子量: 264.37
• InChiKey: BUTPQPZKJTZQIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  27.8
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-<(3-indolyl)phenylmethyl>-i-propylamine 在 盐酸 、 potassium tert-butylate 作用下， 以 乙醚 、 乙醇 、 溶剂黄146 、 甲苯 为溶剂， 反应 126.0h， 生成 3,3-diethoxycarbonyl-4-phenyl-1,2,3,4-tetrahydrospiro<β-carboline-1,1'-cyclohexane>
  参考文献：
  名称：

  Synthesis and analgesic evaluation of some 1,1-disubstituted 3-carboxy-4-phenyl-1,2,3,4-tetrahydro-β-carboline derivatives

  摘要：

  New 4-phenyl-1,2,3,4-tetrahydro-beta-carbolines were synthesized from beta-phenyltryptophan ester. They were evaluated in induced pain on rodents. Amide 17b proved to be the most powerful in the series. Several compounds display significative antiinflammatory properties.

  DOI：

  10.1016/0223-5234(96)88272-9
• 作为产物：
  描述：

  苯甲醛 、 alkaline earth salt of/the/ methylsulfuric acid 以 溶剂黄146 、 苯 为溶剂， 反应 2.5h， 生成 N-<(3-indolyl)phenylmethyl>-i-propylamine
  参考文献：
  名称：

  Synthesis and analgesic evaluation of some 1,1-disubstituted 3-carboxy-4-phenyl-1,2,3,4-tetrahydro-β-carboline derivatives

  摘要：

  New 4-phenyl-1,2,3,4-tetrahydro-beta-carbolines were synthesized from beta-phenyltryptophan ester. They were evaluated in induced pain on rodents. Amide 17b proved to be the most powerful in the series. Several compounds display significative antiinflammatory properties.

  DOI：

  10.1016/0223-5234(96)88272-9

文献信息

• Synthesis and analgesic evaluation of some 1,1-disubstituted 3-carboxy-4-phenyl-1,2,3,4-tetrahydro-β-carboline derivatives
  作者：T Nagy、L Jeannin、J Sapi、JY Laronze、P Renard、B Pfeiffer、JG Bizot-Espiard

  DOI：10.1016/0223-5234(96)88272-9

  日期：1995.1

  New 4-phenyl-1,2,3,4-tetrahydro-beta-carbolines were synthesized from beta-phenyltryptophan ester. They were evaluated in induced pain on rodents. Amide 17b proved to be the most powerful in the series. Several compounds display significative antiinflammatory properties.