6-bromo-3-ethyl-2-methyl-1H-quinoline-4-thione | 332150-09-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-bromo-3-ethyl-2-methyl-1H-quinoline-4-thione
• CAS: 332150-09-1
• 化学式: C₁₂H₁₂BrNS
• 分子量: 282.204
• InChiKey: NDBOJGIMJCALBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  44.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-bromo-3-ethyl-2-methyl-1H-quinoline-4-thione 、 丙烯酸 在 盐酸 作用下， 以 水 为溶剂， 以79%的产率得到3-(6-bromo-3-ethyl-2-methylquinolin-4-ylsulfanyl)propionic acid
  参考文献：
  名称：

  Synthesis of (2-methylquinolin-4-ylsulfanyl)-substituted acetic and propionic acids and propionitriles

  摘要：

  A procedure has been developed for the synthesis of (2-methylquinolin-4-ylsulfanyl)-substituted acetic and propionic acids and propionitriles having methyl, methoxy, or carboxy groups or halogen atom in position 6 or 8 of the quinoline ring via reactions of the corresponding substituted 2-methylquinoline-4-thiols with chloroacetic or acrylic acid and acrylonitrile.

  DOI：

  10.1134/s1070428010040226

文献信息

• Synthesis of (2-methylquinolin-4-ylsulfanyl)-substituted acetic and propionic acids and propionitriles
  作者：A. A. Avetisyan、I. L. Aleksanyan、V. G. Durgaryan

  DOI：10.1134/s1070428010040226

  日期：2010.4

  A procedure has been developed for the synthesis of (2-methylquinolin-4-ylsulfanyl)-substituted acetic and propionic acids and propionitriles having methyl, methoxy, or carboxy groups or halogen atom in position 6 or 8 of the quinoline ring via reactions of the corresponding substituted 2-methylquinoline-4-thiols with chloroacetic or acrylic acid and acrylonitrile.