Gerberin | 125445-59-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Gerberin
• 英文别名: (2S)-2-methyl-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2,3-dihydropyran-6-one
• CAS: 125445-59-2
• 化学式: C₁₂H₁₈O₈
• 分子量: 290.27
• InChiKey: VOGIOFXGPGYBDO-QHUZOQRCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  126
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  Gerberin 在 对甲苯磺酸 作用下， 以 吡啶 为溶剂， 反应 7.0h， 生成 5,6-dihydro-4-methoxy-6-methyl-2-pyrone
  参考文献：
  名称：

  Nagumo, Seiji; Toyonaga, Tatsunori; Inoue, Takao, Chemical and pharmaceutical bulletin, 1989, vol. 37, # 10, p. 2621 - 2623

  摘要：

  DOI：

文献信息

• Liposome composition for delivery of therapeutic agents
  申请人：Zalipsky Samuel

  公开号：US20050191344A1

  公开（公告）日：2005-09-01

  A neutral cationic lipid and liposomes prepared from the neutral cationic lipid are described. Liposomes comprised of the lipid are suitable for delivery of a polyanionic compound, such as a nucleic acid. The delivery can be performed in vivo or ex vivo. The neutral cationic lipid, which is neutral in charge at physiologic pH and positively charged at pH values less than physiologic pH, contains a polar head group that imparts solubility of the lipid and permits its packing into a liposomal lipid bilayer.

  本文描述了一种中性阳离子脂质和用该中性阳离子脂质制备的脂质体。由该脂质组成的脂质体适用于递送多阴离子化合物，如核酸。输送可在体内或体外进行。中性阳离子脂质在生理 pH 值下带中性电荷，而在 pH 值低于生理 pH 值时则带正电荷，它含有一个极性头基，可增加脂质的溶解性，并使其能够填入脂质体脂质双分子层。
• LIPOSOME COMPOSITION FOR DELIVERY OF THERAPEUTIC AGENTS
  申请人：ALZA CORPORATION

  公开号：EP1706149A2

  公开（公告）日：2006-10-04
• [EN] LIPOSOME COMPOSITION FOR DELIVERY OF THERAPEUTIC AGENTS<br/>[FR] COMPOSITION DE LIPOSOMES POUR L'ADMINISTRATION D'AGENTS THERAPEUTIQUES
  申请人：ALZA CORP

  公开号：WO2005070466A2

  公开（公告）日：2005-08-04

  A neutral cationic lipid and liposomes prepared from the neutral cationic lipid are described. Liposomes comprised of the lipid are suitable for delivery of a polyanionic compound, such as a nucleic acid. The delivery can be performed in vivo or ex vivo. The neutral cationic lipid, which is neutral in charge at physiologic pH and positively charged at pH values less than physiologic pH, contains a polar head group that imparts solubility of the lipid and permits its packing into a liposomal lipid bilayer.
• Nagumo, Seiji; Toyonaga, Tatsunori; Inoue, Takao, Chemical and pharmaceutical bulletin, 1989, vol. 37, # 10, p. 2621 - 2623
  作者：Nagumo, Seiji、Toyonaga, Tatsunori、Inoue, Takao、Nagai, Masahiro

  DOI：——

  日期：——