Fmoc-L-Lys(COCF3)-D-Ala-D-Ala-OAllyl | 906748-57-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Fmoc-L-Lys(COCF3)-D-Ala-D-Ala-OAllyl
• 英文别名: Fmoc-Lys(Tfa)-D-Ala-D-Ala-Oallyl；prop-2-enyl (2R)-2-[[(2R)-2-[[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-6-[(2,2,2-trifluoroacetyl)amino]hexanoyl]amino]propanoyl]amino]propanoate
• CAS: 906748-57-0
• 化学式: C₃₂H₃₇F₃N₄O₇
• 分子量: 646.664
• InChiKey: OLTGXYYWHCZBIE-KYTVRQNUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  46
• 可旋转键数：
  17
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  152
• 氢给体数：
  4
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  Fmoc-L-Lys(COCF3)-D-Ala-D-Ala-OAllyl 在 N-甲基吗啉 、 polymer-supported dimethyl-n-octyl-ammonium fluoride 、 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.51h， 生成 H-L-Ala-γ-D-Glu(OMe)-L-Lys(COCF3)-D-Ala-D-Ala-OAllyl*HCl
  参考文献：
  名称：

  A novel strategy for oligopeptide synthesis using a polymer-supported ammonium fluoride

  摘要：

  A novel method for the preparation of oligopeptides with a PS-ammonium fluoride in the solution phase is reported. The synthesis of lipid 11 pentapeptide is efficiently synthesized via a PS-ammonium fluoride without chromatographic purifications. The method reported here is very convenient to synthesize a relatively large amount of oligopeptides with abundantly available Fmoc-protected amino acids in a time efficient manner. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.05.129
• 作为产物：
  描述：

  Fmoc-D-Ala-D-Ala-OAllyl 在 N-甲基吗啉 、 polymer-supported dimethyl-n-octyl-ammonium fluoride 、 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.17h， 生成 Fmoc-L-Lys(COCF3)-D-Ala-D-Ala-OAllyl
  参考文献：
  名称：

  A novel strategy for oligopeptide synthesis using a polymer-supported ammonium fluoride

  摘要：

  A novel method for the preparation of oligopeptides with a PS-ammonium fluoride in the solution phase is reported. The synthesis of lipid 11 pentapeptide is efficiently synthesized via a PS-ammonium fluoride without chromatographic purifications. The method reported here is very convenient to synthesize a relatively large amount of oligopeptides with abundantly available Fmoc-protected amino acids in a time efficient manner. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.05.129

文献信息

• A novel strategy for oligopeptide synthesis using a polymer-supported ammonium fluoride
  作者：Michio Kurosu、Dean C. Crick

  DOI：10.1016/j.tetlet.2006.05.129

  日期：2006.7

  A novel method for the preparation of oligopeptides with a PS-ammonium fluoride in the solution phase is reported. The synthesis of lipid 11 pentapeptide is efficiently synthesized via a PS-ammonium fluoride without chromatographic purifications. The method reported here is very convenient to synthesize a relatively large amount of oligopeptides with abundantly available Fmoc-protected amino acids in a time efficient manner. (c) 2006 Elsevier Ltd. All rights reserved.