2,6-Bis[(4-methylpiperazin-1-yl)methyl]-4-[(2-naphthalen-2-ylquinolin-4-yl)amino]phenol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2,6-Bis[(4-methylpiperazin-1-yl)methyl]-4-[(2-naphthalen-2-ylquinolin-4-yl)amino]phenol
• 化学式: C₃₇H₄₂N₆O
• 分子量: 586.78
• InChiKey: DQEWAUJKEHDOBI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  44
• 可旋转键数：
  7
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  58.1
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  4-chloro-2-(2-naphthyl)quinoline 以 乙醇 、 水 为溶剂， 反应 28.0h， 生成 2,6-Bis[(4-methylpiperazin-1-yl)methyl]-4-[(2-naphthalen-2-ylquinolin-4-yl)amino]phenol
  参考文献：
  名称：

  Structure-activity relationship analysis of substituted 4-quinolinamines, antagonists of immunostimulatory CpG-oligodeoxynucleotides

  摘要：

  On the basis of a systematic SAR analysis of substituted quinolines, a derivative 32 was synthesized that shows half-maximal inhibition of the immunostimulatory effect of CpG-oligodeoxynucleotides in vitro at the concentration of 0.24 nM. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00291-7

文献信息

• Structure-activity relationship analysis of substituted 4-quinolinamines, antagonists of immunostimulatory CpG-oligodeoxynucleotides
  作者：Lucjan Strekowski、Oliwia Zegrocka、Maged Henary、Martial Say、Maria J. Mokrosz、Barbara M. Kotecka、Lori Manzel、Donald E. Macfarlane

  DOI：10.1016/s0960-894x(99)00291-7

  日期：1999.7

  On the basis of a systematic SAR analysis of substituted quinolines, a derivative 32 was synthesized that shows half-maximal inhibition of the immunostimulatory effect of CpG-oligodeoxynucleotides in vitro at the concentration of 0.24 nM. (C) 1999 Elsevier Science Ltd. All rights reserved.