4-Anilino-3-cyanoquinoline deriv. 7d

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-Anilino-3-cyanoquinoline deriv. 7d
• 英文别名: 4-(3,5-dimethoxyanilino)-6,7-dimethoxyquinoline-3-carbonitrile
• 化学式: C₂₀H₁₉N₃O₄
• 分子量: 365.389
• InChiKey: QSVJJSNSEULONW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  85.6
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  3,5-二甲氧基苯胺 、 4-氯-3-氰基-6,7-二甲氧基喹啉 在 吡啶盐酸盐 作用下， 以 乙二醇乙醚 为溶剂， 生成 4-Anilino-3-cyanoquinoline deriv. 7d
  参考文献：
  名称：

  Inhibitors of Src tyrosine kinase: the preparation and structure–activity relationship of 4-anilino-3-cyanoquinolines and 4-anilinoquinazolines

  摘要：

  Src is a nonreceptor tyrosine kinase involved in signaling pathways that control proliferation, migration, and angiogenesis. Increased Src expression and activity are associated with an increase in tumor malignancy and poor prognosis. Several quinolines and quinazolines were identified as potent and selective inhibitors of Src kinase activity. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00493-5

文献信息

• Inhibitors of Src tyrosine kinase: the preparation and structure–activity relationship of 4-anilino-3-cyanoquinolines and 4-anilinoquinazolines
  作者：Yanong D. Wang、Karen Miller、Diane H. Boschelli、Fei Ye、Biqi Wu、M.Brawner Floyd、Dennis W. Powell、Allan Wissner、Jennifer M. Weber、Frank Boschelli

  DOI：10.1016/s0960-894x(00)00493-5

  日期：2000.11

  Src is a nonreceptor tyrosine kinase involved in signaling pathways that control proliferation, migration, and angiogenesis. Increased Src expression and activity are associated with an increase in tumor malignancy and poor prognosis. Several quinolines and quinazolines were identified as potent and selective inhibitors of Src kinase activity. (C) 2000 Elsevier Science Ltd. All rights reserved.