4-methoxy-3-methyl-butan-1-ol | 127290-59-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-methoxy-3-methyl-butan-1-ol
• 英文别名: 4-Methoxy-3-methylbutan-1-ol
• CAS: 127290-59-9
• 化学式: C₆H₁₄O₂
• 分子量: 118.176
• InChiKey: ICRDMZNNGNTEGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-methoxy-3-methyl-butan-1-ol 在 吡啶 、 氯化亚砜 作用下， 生成 isopropyl-(4-methoxy-3-methyl-butyl)-amine
  参考文献：
  名称：

  Synthesis of the Branched Chain 5-Isopropylaminoamyl and 4-Isopropylaminobutyl Ethers and of the Bromides Derived from Them^1,2

  摘要：

  DOI：

  10.1021/ja01159a071
• 作为产物：
  描述：

  聚合甲醛 、 alkaline earth salt of/the/ methylsulfuric acid 在 乙醚 作用下， 生成 4-methoxy-3-methyl-butan-1-ol
  参考文献：
  名称：

  Synthesis of the Branched Chain 5-Isopropylaminoamyl and 4-Isopropylaminobutyl Ethers and of the Bromides Derived from Them^1,2

  摘要：

  DOI：

  10.1021/ja01159a071

文献信息

• Substituted piperidines as therapeutic compounds
  申请人：Speedel Experimenta AG

  公开号：EP2018862A1

  公开（公告）日：2009-01-28

  Described are compounds of the general formula (I) and pharmaceutically acceptable salt thereof, in which R2, R3, W,and X have the definitions illustrated in detail in the description, as beta-secretase, cathepsin D, plasmepsin II and/or HIV protease inhibitors.

  描述了一般式（I）的化合物及其药用可接受的盐，其中R2、R3、W和X的定义在描述中详细说明，作为β-分泌酶、半胱氨酸蛋白酶D、质体蛋白酶II和/或HIV蛋白酶抑制剂。
• Iodine/iodide-containing hot melt coatable adhesive, methods and uses therefor
  申请人：Wang Danli

  公开号：US20050202070A1

  公开（公告）日：2005-09-15

  An iodine/iodide-containing hot melt coatable adhesive is provided. This adhesive is prepared by mixing iodine and an iodide salt, individually or in combination, with solubilizing liquids. The iodine and iodide salt are combined with a pre-adhesive composition in a hot melt mixer, with an iodine/iodide complexing agent being present in the mixture. The mixture is mixed at a temperature from about 130° C. to about 200° C. and sufficiently to form an iodine/iodide-containing hot melt coatable adhesive. Alternatively, the iodide may be generated in situ. The adhesive so prepared may be packaged for coating on a substrate at a later time, or may be immediately coated to form an adhesive composite. Adhesive composites, particularly surgical incise drapes, are provided incorporating this hot melt coatable adhesive.

  提供了一种含碘/碘化物的热熔涂层粘合剂。该粘合剂是通过将碘和碘化物单独或组合与溶解液混合而制备的。碘和碘化物与预粘合剂组合在热熔混合器中，其中碘/碘化物络合剂存在于混合物中。混合物在温度从约130℃到约200℃之间混合足够长的时间，从而形成含碘/碘化物的热熔涂层粘合剂。或者，碘化物可以在原位生成。这样制备的粘合剂可以打包，以便在以后涂覆在基材上，也可以立即涂覆以形成粘合剂复合材料。提供了包含这种热熔涂层粘合剂的粘合剂复合材料，特别是外科手术切口防护膜。
• [EN] IMIDAZOPYRIDINE DERIVATIVES AS KINASE INHIBITORS<br/>[FR] DERIVES D'IMIDAZOPYRIDINE EN TANT QU'INHIBITEURS DE KINASE
  申请人：GLAXO GROUP LTD

  公开号：WO2003080610A1

  公开（公告）日：2003-10-02

  A compound of the formula: (I) and-physiologically acceptable salts and or N-oxides thereof wherein, X1 is N or CR.3; X2 is N or CR'4; X3 ,is..N or CR5; X4 is N or CR6 with the proviso that at least one but not more than two of X1, X 2, X,3. and X4 represents N. R1 is a 5-, or 6-membered heterocyclic group selected from group a, b, c or d formula: (II) wherein X5 is a group selected from N or CR7: and X6, is a group selected from O, S or NR8; X7 and X8; which maybe the same or, different is a group selected from N or CR9; ; X9, is a group selected from O, S or NR8 and X10 is N or CR10 ; X11 , X12 and X13 may be the same or different and selected from a group N or CR11 ; processes for their preparation, pharmaceutical compositions containing them and their use in medicine.

  化合物的式子为：（I），其生理上可接受的盐和/或N-氧化物，其中，X1为N或CR.3；X2为N或CR'4；X3为N或CR5；X4为N或CR6，但至少其中一个但不超过两个X1、X2、X3和X4代表N。R1是从a、b、c或d组中选择的5-或6-成员杂环基，式子为：（II），其中X5是从N或CR7选择的基团；X6是从O、S或NR8选择的基团；X7和X8可以相同或不同，是从N或CR9选择的基团；X9是从O、S或NR8选择的基团，X10是N或CR10；X11、X12和X13可以相同或不同，是从N或CR11的基团中选择的；制备它们的过程，包含它们的制药组合物以及它们在医学上的用途。
• Imidazopyridine derivatives as kinase inhibitors
  申请人：Bailey Nicholas

  公开号：US20050197328A1

  公开（公告）日：2005-09-08

  A compound of the formula and physiologically acceptable salts and or N-oxides thereof wherein, X 1 is N or CR 3 ; X 2 is N or CR 4 ; X 3 is N or CR 5 ; X 4 is N or CR 6 . with the proviso that at least one but not more than two of X 1 , X 2 , X 3 and X 4 represents N. R 1 is a 5-, or 6-membered heterocyclic group selected from group a, b, c or d wherein X 5 is a group selected from N or CR 7 and X 6 is a group selected from O, S or NR 8; X 7 and X 8 which may be the same or different is a group selected from N or CR 9; X 9 is a group selected from O, S or NR 8 and X 10 is N or CR 10; X 11 , X 12 and X 13 may be the same or different and selected from a group N or CR 11 ; processes for their preparation, pharmaceutical compositions containing them and their use in medicine.

  式中化合物及其生理上可接受的盐和/或N-氧化物，其中： X1为N或CR3； X2为N或CR4； X3为N或CR5； X4为N或CR6； 但须满足X1、X2、X3和X4中至少一个但不超过两个为N； R1为从a、b、c或d组中选择的5-或6-成员杂环基，其中X5为N或CR7组，X6为O、S或NR8组； X7和X8可以相同或不同，为N或CR9组； X9为O、S或NR8组，X10为N或CR10组； X11、X12和X13可以相同或不同，为N或CR11组； 本发明还涉及其制备方法、包含它们的制药组合物以及它们在医学上的应用。
• SUBSTITUTED 4-PHENYLPIPERIDINES
  申请人：Herold Peter

  公开号：US20090029981A1

  公开（公告）日：2009-01-29

  The application relates to substituted 4-phenylpiperidines of the general formula and their salts, preferably their pharmaceutically acceptable salts, in which R 2 , R 3 , W and X have the meanings explained in the description, a process for their preparation and the use of these compounds as medicines, especially as renin inhibitors.

  该申请涉及通式中的取代的4-苯基哌啶及其盐，优选其药学上可接受的盐，其中R2、R3、W和X的含义在说明中解释，以及它们的制备方法和这些化合物作为药物的用途，特别是作为肾素抑制剂。