(S)-2-benzyloxy-5,6,7,8-tetrahydro-quinolin-5-ylamine | 286381-74-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (S)-2-benzyloxy-5,6,7,8-tetrahydro-quinolin-5-ylamine
• 英文别名: (S)-(+)-2-benzyloxy-5,6,7,8-tetrahydro-5-quinolinamine；(S)-2-(Benzyloxy)-5,6,7,8-tetrahydroquinolin-5-amine；(5S)-2-phenylmethoxy-5,6,7,8-tetrahydroquinolin-5-amine
• CAS: 286381-74-6
• 化学式: C₁₆H₁₈N₂O
• 分子量: 254.332
• InChiKey: KYPGUAIHLBHSMY-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  48.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (S)-2-benzyloxy-5,6,7,8-tetrahydro-quinolin-5-ylamine 在 硼烷四氢呋喃络合物 、 三乙胺 作用下， 以 苯 为溶剂， 反应 18.0h， 生成 N,N'-Bis-((S)-2-benzyloxy-5,6,7,8-tetrahydro-quinolin-5-yl)-undecane-1,11-diamine
  参考文献：
  名称：

  Dimerization of an Inactive Fragment of Huperzine A Produces a Drug with Twice the Potency of the Natural Product

  摘要：

  DOI：

  10.1002/(sici)1521-3773(20000515)39:10<1775::aid-anie1775>3.0.co;2-q
• 作为产物：
  描述：

  5,6,7,8-tetrahydro-2-(phenylmethoxy)-5-oxoquinoline 在 吡啶 、 硼烷四氢呋喃络合物 作用下， 反应 28.0h， 生成 (S)-2-benzyloxy-5,6,7,8-tetrahydro-quinolin-5-ylamine
  参考文献：
  名称：

  Dimerization of an Inactive Fragment of Huperzine A Produces a Drug with Twice the Potency of the Natural Product

  摘要：

  DOI：

  10.1002/(sici)1521-3773(20000515)39:10<1775::aid-anie1775>3.0.co;2-q

文献信息

• Heterodimers and Methods of Using Them
  申请人：IP Nancy Y.

  公开号：US20080176308A1

  公开（公告）日：2008-07-24

  Novel heterodimers of tetrahydroacridines and tetrahydroquinolinones are disclosed. The heterodimers are capable of acting as both acetylcholinesterase inhibitors and N-methyl-D-aspartate (NMDA) receptor antagonists. The heterodimers may be used to improve cognitive defects via treatment or prevention in both humans and non-humans.

  揭示了新型四氢喹啉和四氢喹啉酮的异源二聚体。这些异源二聚体能够同时作为乙酰胆碱酯酶抑制剂和N-甲基-D-天冬氨酸（NMDA）受体拮抗剂。这些异源二聚体可用于改善人类和非人类的认知缺陷，通过治疗或预防。
• Dimeric compounds
  申请人：——

  公开号：US20020156096A1

  公开（公告）日：2002-10-24

  The invention relates to dimeric compounds comprising two 5-amino-5,6,7,8-tetrahydroquinoline fragments joined together by a divalent linking group, processes for their preparation, intermediates for their preparation, pharmaceutical compositions containing such dimeric compounds and the use of such compounds as cholinesterase inhibitors and in the treatment of neurodegenerative diseases, such as Alzheimer's Disease and myasthenia gravis.

  这项发明涉及由双价连接基团连接在一起的两个5-氨基-5,6,7,8-四氢喹啉片段构成的二聚化合物，以及其制备方法、制备中间体、含有这种二聚化合物的药物组合物，以及将这种化合物用作胆碱酯酶抑制剂和治疗神经退行性疾病，如阿尔茨海默病和重症肌无力的用途。
• Heterodimers and methods of using them
  申请人：Biotechnology Research Corporation Ltd.

  公开号：US07605265B2

  公开（公告）日：2009-10-20

  Novel heterodimers of tetrahydroacridines and tetrahydroquinolinones are disclosed. The heterodimers are capable of acting as both acetylcholinesterase inhibitors and N-methyl-D-aspartate (NMDA) receptor antagonists. The heterodimers may be used to improve cognitive defects via treatment or prevention in both humans and non-humans.

  本发明揭示了四氢喹啉酮和四氢咯啉酸的新型杂二聚物。这些杂二聚物既能作为乙酰胆碱酯酶抑制剂，又能作为N-甲基-D-天门冬氨酸（NMDA）受体拮抗剂。这些杂二聚物可用于治疗或预防人类和非人类的认知缺陷。
• Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors
  作者：Yueqing Hu、Jun Zhang、Oormila Chandrashankra、Fanny C.F. Ip、Nancy Y. Ip

  DOI：10.1016/j.bmc.2012.11.044

  日期：2013.2

  Four series of novel heterodimers comprised of donepezil and huperzine A (HupA) fragments were designed, synthesized, and evaluated in search of potent acetylcholinesterase (AChE) inhibitors as potential therapeutic treatment for Alzheimer's disease. Heterodimers comprised of dimethoxyindanone (from donepezil), hupyridone (from HupA), and connected with a multimethylene linker, were identified as potent and selective inhibitors of AChE. Diastereomeric heterodimers (RS,S)-17b (with a tetramethylene linker) exhibited the highest potency of inhibition towards AChE with an IC50 value of 9 nM and no detectable inhibitory effect on butyrylcholinesterase at 1 mM. (C) 2012 Elsevier Ltd. All rights reserved.
• US6472408B1
  申请人：——

  公开号：US6472408B1

  公开（公告）日：2002-10-29