7-bromo-5-fluoro-8-hydroxyquinoline | 37171-58-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-bromo-5-fluoro-8-hydroxyquinoline
• 英文别名: 5-Fluor-7-brom-8-hydroxychinolin；7-Bromo-5-fluoro-8-quinolinol；7-bromo-5-fluoroquinolin-8-ol
• CAS: 37171-58-7
• 化学式: C₉H₅BrFNO
• 分子量: 242.047
• InChiKey: IYVMXMJAYLDUHH-UHFFFAOYSA-N

物化性质

• 沸点：
  338.9±37.0 °C(Predicted)
• 密度：
  1.784±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-氟-8-羟基喹啉 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 氯仿 为溶剂， 以30%的产率得到7-bromo-5-fluoro-8-hydroxyquinoline
  参考文献：
  名称：

  [EN] 8-HYDROXYQUINOLINE DERIVATIVES AS DIAGNOSTIC AND THERAPEUTIC AGENTS
  [FR] DÉRIVÉS DE 8-HYDROXYQUINOLÉINE EN TANT QU'AGENTS DIAGNOSTIQUES ET THÉRAPEUTIQUES

  摘要：

  本申请提供了在治疗神经系统疾病如阿尔茨海默病以及癌症如前列腺癌方面有用的化合物。本文还提供了用于成像技术的放射标记化合物，以及用于诊断和监测神经系统疾病和癌症治疗的技术。本文提供的示例放射标记化合物可用作正电子发射断层扫描或单光子发射计算机断层扫描的放射追踪剂。还提供了制备放射标记化合物和非标记化合物的方法。

  公开号：

  WO2017027064A1

文献信息

• [EN] 8-HYDROXYQUINOLINE DERIVATIVES AS DIAGNOSTIC AND THERAPEUTIC AGENTS<br/>[FR] DÉRIVÉS DE 8-HYDROXYQUINOLÉINE EN TANT QU'AGENTS DIAGNOSTIQUES ET THÉRAPEUTIQUES
  申请人：MASSACHUSETTS GEN HOSPITAL

  公开号：WO2017027064A1

  公开（公告）日：2017-02-16

  The present application provides compounds useful in methods of treating neurological disorders such as Alzheimer's disease, and cancer such as prostate cancer. Also provided herein are radiolabeled compounds useful for imaging techniques, and techniques for diagnosis and monitoring of treatment of neurological disorders and cancer. An exemplary radiolabeled compound provided herein is useful as a radiotracer for positron emission tomography or single- photon emission computed tomography. Methods for preparing radiolabeled compounds and methods for preparing unlabeled compounds are also provided.

  本申请提供了在治疗神经系统疾病如阿尔茨海默病以及癌症如前列腺癌方面有用的化合物。本文还提供了用于成像技术的放射标记化合物，以及用于诊断和监测神经系统疾病和癌症治疗的技术。本文提供的示例放射标记化合物可用作正电子发射断层扫描或单光子发射计算机断层扫描的放射追踪剂。还提供了制备放射标记化合物和非标记化合物的方法。
• Compositions and Methods Incorporating Photocatalysts
  申请人：Baker Ellen Schmidt

  公开号：US20090285768A1

  公开（公告）日：2009-11-19

  The various embodiments provide a composition including an active material having functional groups capable of covalent attachment to a substrate in the presence of an acid or a base, a photocatalyst capable of generating an acid or a base upon exposure to light, and a vehicle. The compositions may also include surfactants, emulsifiers, oxidants, and other components. A method for treating a substrate is also disclosed. The method includes the steps of applying at least one active material having functional groups to the substrate, applying a photocatalyst to the substrate, and exposing the photocatalyst and the at least one active material to light for forming covalent attachments between the functional groups and constituent groups on the substrate. The compositions and methods described herein are useful in personal care product and consumer care product applications, for example.

  各种实施例提供了一种组合物，包括具有在酸或碱存在下能够与基底共价结合的功能基团的活性材料，能够在光照下生成酸或碱的光催化剂，以及载体。该组合物还可以包括表面活性剂、乳化剂、氧化剂和其他组分。还公开了一种处理基底的方法。该方法包括将至少一种具有功能基团的活性材料应用于基底，将光催化剂应用于基底，并将光照射到光催化剂和至少一种活性材料，以形成功能基团与基底上的成分基团之间的共价结合。这里描述的组合物和方法在个人护理产品和消费者护理产品应用中是有用的。
• Shaping keratin fibers using arabinose and ethylene carbonate
  申请人：The Procter & Gamble Company

  公开号：US10195130B2

  公开（公告）日：2019-02-05

  A method for shaping keratin fibers including providing a crosslinking composition, wherein the crosslinking composition includes ethylene carbonate, arabinose, a photocatalyst being a hydroxy-substituted aromatic compound, and a cosmetically acceptable carrier; applying the crosslinking composition to keratin fibers; and mechanically shaping the keratin fibers with an appliance at a temperature of from 80° C. to 180° C. while exposing the crosslinking composition to electromagnetic radiation having a wavelength of from 300 nm to 750 nm.

  一种塑造角蛋白纤维的方法，包括提供一种交联组合物，其中交联组合物包括碳酸亚乙酯、阿拉伯糖、一种光催化剂（一种羟基取代的芳香族化合物）和一种美容上可接受的载体；将交联组合物涂在角蛋白纤维上；以及在80° C至180° C的温度下用一种器具机械地塑造角蛋白纤维，同时将交联组合物暴露于波长为300 nm至750 nm的电磁辐射中。
• Shaping keratin fibres using 2-oxazolidinone compounds
  申请人：The Procter & Gamble Company

  公开号：US10543156B2

  公开（公告）日：2020-01-28

  Described herein is a method for shaping keratin fibres including (i) providing a crosslinking composition, wherein the crosslinking composition includes a 2-oxazolidinone compound, a photocatalyst being a hydroxy-substituted aromatic compound, and a cosmetically acceptable carrier; (ii) applying the crosslinking composition to keratin fibres; and (iii) mechanically shaping the keratin fibres with an appliance at a temperature of from about 80° C. to about 180° C. while exposing the crosslinking composition to electromagnetic radiation having a wavelength of from about 300 nm to about 750 nm.

  本文描述了一种用于塑造角蛋白纤维的方法，包括(i) 提供一种交联组合物，其中交联组合物包括 2-噁唑烷酮化合物、羟基取代芳香族化合物光催化剂和美容上可接受的载体；(ii) 将交联组合物涂在角蛋白纤维上；以及(iii) 在约 80° C 至约 180° C 的温度下用器具机械塑造角蛋白纤维。至约 180 摄氏度，同时将交联组合物暴露于波长为约 300 纳米至约 750 纳米的电磁辐射中。
• Shaping keratin fibres using a pretreatment and a protein crosslinking composition
  申请人：The Procter & Gamble Company

  公开号：US10568826B2

  公开（公告）日：2020-02-25

  Described herein is a method for shaping keratin fibers including providing a pretreatment composition which includes a pretreatment active agent; applying the pretreatment composition to keratin fibers; leaving the pretreatment composition on the keratin fibers for a time period from about 5 minutes to about 24 hours; providing a crosslinking composition including from about 1% to about 20% of one or more protein crosslinking agents and a cosmetically acceptable carrier; applying the crosslinking composition to keratin fibers; and mechanically shaping the keratin fibers with an appliance at a temperature of from about 50° C. to about 280° C.

  本文描述的是一种塑造角蛋白纤维的方法，包括提供一种预处理组合物，其中包括一种预处理活性剂；将预处理组合物涂在角蛋白纤维上；将预处理组合物留在角蛋白纤维上约5分钟至约24小时；提供一种交联组合物，其中包括约 1%至约 20%的一种或多种蛋白质交联剂和一种美容上可接受的载体；将交联组合物涂在角蛋白纤维上；并用一种设备在约 50°C 至约 280°C 的温度下对角蛋白纤维进行机械塑形。至约 280 摄氏度