1-methoxy-3-methyl-butan-2-ol | 74817-48-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-methoxy-3-methyl-butan-2-ol
• 英文别名: 1-Methoxy-3-methylbutan-2-ol
• CAS: 74817-48-4
• 化学式: C₆H₁₄O₂
• mdl: MFCD14691023
• 分子量: 118.176
• InChiKey: XFYWHZOKFISCGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,2-环氧-3-甲基丁烷 、 甲醇 、 sodium methylate 生成 1-methoxy-3-methyl-butan-2-ol
  参考文献：
  名称：

  Tjashelowa, Zhurnal Obshchei Khimii, 1948, vol. 18, p. 449

  摘要：

  DOI：

文献信息

• NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF
  申请人：SAGE THERAPEUTICS, INC.

  公开号：US20160022701A1

  公开（公告）日：2016-01-28

  Provided are methods of evaluating or treating a patient, e.g., a patient having a disorder described herein, comprising: a) optionally, acquiring a patient sample; b) acquiring an evaluation of and/or evaluating the sample for an alteration in the level S24(S)-hydroxycholesterol compared to a reference standard.

  提供了评估或治疗患者的方法，例如，患有本文所述疾病的患者，包括：a) 可选地，获取患者样本；b) 获取对样本的评估和/或评估其S24(S)-羟基胆固醇水平与参考标准相比是否发生改变。
• NOVEL PHENYL-ISOXAZOL-3-OL DERIVATIVE
  申请人：Hashimoto Noriaki

  公开号：US20100130559A1

  公开（公告）日：2010-05-27

  The present invention relates to a compound represented by formula (I), which has a GPR120 agonist action and thus is useful for treatment of diabetes mellitus or hyperlipidemia, or a pharmaceutically acceptable salt thereof. In the formula, (AA) represents a phenyl or the like, which may be substituted with a lower alkoxy group or the like; (BB) represents a divalent group or the like, derived by removal of two hydrogen atoms from a benzene which may be substituted with a halogen atom or the like; X represents a spacer having a main chain composed of 1-8 carbon atoms wherein 1-3 carbon atoms in the main chain may be substituted with an oxygen atom or the like; and Y represents a hydrogen atom or the like.

  本发明涉及一种由式(I)所表示的化合物，该化合物具有GPR120激动剂作用，因此可用于治疗糖尿病或高脂血症，或其药学上可接受的盐。在该式中，(AA)代表苯或类似物，可能被低烷氧基或类似物取代；(BB)代表二价基团或类似物，由苯中去除两个氢原子而来，该苯可能被卤原子或类似物取代；X代表具有由1-8个碳原子组成的主链的间隔物，其中主链中的1-3个碳原子可能被氧原子或类似物取代；而Y代表氢原子或类似物。
• Compounds, Compositions and Methods for Treating Ocular Conditions
  申请人：Painter George R.

  公开号：US20120165295A1

  公开（公告）日：2012-06-28

  The present invention provides methods of treating viral infection of the eye or posterior ocular condition including administering a pharmaceutical composition comprising a compound described in the present application. In some embodiments, the pharmaceutical composition is topically administered. In another embodiment, the pharmaceutical composition is orally administered or intraocularly administered.
• NEUROACTIVE COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Sage Therapeutics, Inc.

  公开号：US20170304321A1

  公开（公告）日：2017-10-26

  Methods for treating a subject suffering from a sterol synthesis disorder or a sterol deficiency disorder, e.g., Smith-Lemli-Opitz syndrome, the method comprising administering to the subject an effective amount of an NMDA receptor modulating compound, are provided.
• US8383695B2
  申请人：——

  公开号：US8383695B2

  公开（公告）日：2013-02-26