5-[[2,6-difluoro-4-(4-propylcyclohexyl)phenyl]difluoromethoxy]-1,2,3-trifluorobenzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-[[2,6-difluoro-4-(4-propylcyclohexyl)phenyl]difluoromethoxy]-1,2,3-trifluorobenzene
• 英文别名: 5-[[2,6-Difluoro-4-(trans-4-propylcyclohexyl)phenyl]difluoromethoxy]-1,2,3-trifluorobenzene；2-[difluoro-(3,4,5-trifluorophenoxy)methyl]-1,3-difluoro-5-(4-propylcyclohexyl)benzene
• 化学式: C₂₂H₂₁F₇O
• 分子量: 434.397
• InChiKey: AZSTZWATCSHUNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.5
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  4-丙基环己基酮 在 ruthenium-carbon composite 、 1-(N,N-diethylaminoethyl)-3-methylimidazole tetrafluoroborate 、 氢气 、 对甲苯磺酸 、 magnesium 、 三氟乙酸 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 、 甲苯 为溶剂， -20.0~110.0 ℃ 、300.01 kPa 条件下， 反应 22.17h， 生成 5-[[2,6-difluoro-4-(4-propylcyclohexyl)phenyl]difluoromethoxy]-1,2,3-trifluorobenzene
  参考文献：
  名称：

  一种含有二氟甲基醚桥键的液晶单体化合物的制备方法

  摘要：

  本发明涉及液晶单体化合物合成技术领域，具体公开含有二氟甲基醚桥键的液晶单体化合物的制备方法。式Ⅰ所示的含多氟结构的化合物为原料，以式Ⅱ所示的咪唑类碱性离子液体为催化剂，有效提高了多氟结构原料的转化率，进而提高了目标产品的纯度和收率，制备得到的含有二氟甲基醚桥键的液晶单体化合物的HPLC含量大于99.9％，产品总收率大于85％，同时，还缩短了制备含有二氟甲基醚桥键的液晶单体化合物的工艺流程，且避免了使用成本昂贵的丁基锂试剂，进而避免了超低温反应，对设备要求低，降低了工艺难度，且对环境友好，是一种绿色环保且适合工业化生产的制备含有二氟甲基醚桥键的液晶单体化合物的新工艺。

  公开号：

  CN112125788B

文献信息

• LIQUID CRYSTAL COMPOUND AND LIQUID CRYSTAL COMPOSITION EMPLOYING THE SAME
  申请人：DAXIN MATERIALS CORPORATION

  公开号：US20160222295A1

  公开（公告）日：2016-08-04

  A liquid crystal compound and a composition employing the same are provided. The liquid crystal compound has a structure represented by Formula (I) wherein R1, A1, A2, A3, A4, Z1, Z2, Z3, Z4, X, m, n, o, and p are defined as in the description.

  提供一种液晶化合物和应用该液晶化合物的组合物。该液晶化合物具有由式（I）表示的结构，其中R1、A1、A2、A3、A4、Z1、Z2、Z3、Z4、X、m、n、o和p的定义如描述中所述。
• LIQUID CRYSTAL COMPOUND HAVING DIFLUOROMETHYLENEOXY GROUP, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY DEVICE
  申请人：JNC Corporation

  公开号：EP3275971A1

  公开（公告）日：2018-01-31

  Provided are a liquid crystal compound satisfying at least one of physical properties such as high stability to heat and light, a high clearing point (or high maximum temperature), low minimum temperature of the liquid crystal phase, small viscosity, suitable optical anisotropy, large dielectric anisotropy, large dielectric constant in a minor axis direction, a suitable elastic constant and excellent compatibility with other liquid crystal compounds; a liquid crystal composition containing the liquid crystal compound; and a liquid crystal display device including the composition. The compound is represented by formula (1). In formula (1), for example R1 is alkyl having 1 to 12 carbons; ring A1 is 1, 4-cyclohexylene; ring B1 is 1,4-phenylene; Z1, Z2 and Z3 are a single bond; L1, L2, L3, L4, L5, L6, L7, L8 and L9 are hydrogen or halogen; X1 is fluorine; a is 1 to 3; and n1 and n2 are independently 0 or 1.

  本发明提供了一种液晶化合物，该化合物至少满足以下物理特性之一：对热和光的稳定性高、清澈点（或最高温度高）高、液晶相的最低温度低、粘度小、适当的光学各向异性、介电各向异性大、小轴方向上的介电常数大、适当的弹性常数以及与其他液晶化合物的兼容性好；一种含有该液晶化合物的液晶组合物；以及一种包括该组合物的液晶显示设备。 该化合物用式（1）表示。 在式 (1) 中，例如 R1 是具有 1 至 12 个碳原子的烷基；环 A1 是 1，4-环己烯；环 B1 是 1，4-亚苯基；Z1、Z2 和 Z3 是单键；L1、L2、L3、L4、L5、L6、L7、L8 和 L9 是氢或卤素；X1 是氟；a 是 1 至 3；n1 和 n2 独立地为 0 或 1。
• DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION
  申请人：CHISSO CORPORATION

  公开号：EP0786445B1

  公开（公告）日：2002-07-17
• LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE USING THE SAME
  申请人：Kawamura Jouji

  公开号：US20150159089A1

  公开（公告）日：2015-06-11

  It is an object of the present invention to provide a liquid crystal composition having a positive Δ∈, the liquid crystal composition also having a liquid crystal phase in a wide temperature range, a good resistance to resolution at low temperature, an excellent adaptability to an ODF process, a high specific resistance and voltage holding ratio, and stability to heat and light. In order to achieve this object, a liquid crystal composition containing compounds represented by Formulae (i) and (ii) is provided. (where R i1 represents an alkyl group having 1 to 5 carbon atoms or an alkenyl group having 2 to 5 carbon atoms).
• LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE USING SAME
  申请人：DIC Corporation

  公开号：US20150225648A1

  公开（公告）日：2015-08-13

  There is provided a liquid crystal composition containing a compound represented by Formula (i) and a compound represented by General Formula (ii) (where R ii1 and R ii2 each independently represent an alkyl group having 1 to 5 carbon atoms, an alkoxyl group having 1 to 5 carbon atoms, or an alkenyl group having 4 or 5 carbon atoms; and X ii1 and X ii2 each independently represent a hydrogen atom or a fluorine atom). There is also provided a liquid crystal display device in which such a liquid crystal composition is used.